Cystatin C, CRP, log TG/HDLc and metabolic syndrome are associated with microalbuminuria in hypertension.

Abstract:

BACKGROUND:In patients with systemic hypertension, microalbuminuria is a marker of endothelial damage and is associated with an increased risk for cardiovascular disease. OBJECTIVE:To determine the factors that may lead to the occurrence of microalbuminuria in hypertensive patients with serum creatinine lower than 1.5 mg/dL. METHODS:This cross-sectional study included 133 Brazilians with essential hypertension followed up at a hypertension outpatient clinic. Those with serum creatinine higher than 1.5 mg/dL, as well as those with diabetes mellitus, were excluded. Systolic and diastolic blood pressures were measured, and body mass index (BMI) and GFR estimated by using the CKD-EPI formula were calculated. The serum levels of the following were assessed: CysC, creatinine, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, C-reactive protein (CRP) and fasting glucose. Microalbuminuria was determined in 24-hour urine. Hypertensive patients were classified according to the presence of one or more criteria for metabolic syndrome. RESULTS:In a multiple regression analysis, the serum levels of CysC and CRP, the atherogenic index log TG/HDLc and the presence of three or more criteria for metabolic syndrome were positively correlated with microalbuminuria (r2: 0.277, p < 0.05). CONCLUSION:CysC, CRP, log TG/HDLc, and the presence of three or more criteria for metabolic syndrome, regardless of serum creatinine, were associated with microalbuminuria, an early marker of kidney damage and cardiovascular risk in patients with essential hypertension.

journal_name

Arq Bras Cardiol

authors

Moura Rdo S,Vasconcelos DF,Freitas E,Moura FJ,Rosa TT,Veiga JP

doi

10.5935/abc.20130210

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

54-9

issue

1

eissn

0066-782X

issn

1678-4170

pii

S0066-782X2013005000096

journal_volume

102

pub_type

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