Abstract:
BACKGROUND:Benzathine penicillin G every 3 weeks is the standard protocol for secondary prophylaxis for recurrent rheumatic fever. OBJECTIVE:Assess the effect of Benzathine penicillin G on Streptococcus sanguinis and Streptococcus oralis in patients with cardiac valvular disease due to rheumatic fever receiving secondary prophylaxis. METHODS:Oral streptococci were evaluated before (baseline) and after 7 days (day 7) with Benzathine penicillin G in 100 patients receiving routine secondary rheumatic fever prophylaxis. Saliva samples were evaluated for colony count and presence of S. sanguinis and S. oralis. Chewing-stimulated saliva samples were serially diluted and plated onto both nonselective and selective 5% sheep blood agar containing penicillin G. The species were identified using conventional biochemical tests. Minimal inhibitory concentrations were determined with the Etest. RESULTS:No statistical differences were found in the presence of S. sanguinis comparing baseline and day 7 (p = 0.62). However, the existing number of positive cultures of S. oralis on day 7 after Benzathine penicillin G presented a significant increase compared to baseline (p = 0.04). No statistical difference was found between baseline and day 7 concerning the number of S. sanguinis or S. oralis CFU/mL and median minimal inhibitory concentrations. CONCLUSION:This study showed that Benzathine penicillin G every 3 weeks did not change the colonization by S. sanguinis, but increased colonization of S. oralis on day 7 of administration. Therefore, susceptibility of Streptococcus sanguinis and Streptococcus oralis to penicillin G was not modified during the penicillin G routine secondary rheumatic fever prophylaxis.
journal_name
Arq Bras Cardioljournal_title
Arquivos brasileiros de cardiologiaauthors
Aguiar AA,Sampaio RO,Sampaio JL,Spina GS,Neves RS,Moreira LF,Grinberg Mdoi
10.1590/s0066-782x2012005000038subject
Has Abstractpub_date
2012-05-01 00:00:00pages
452-8issue
5eissn
0066-782Xissn
1678-4170pii
S0066-782X2012005000038journal_volume
98pub_type
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journal_title:Arquivos brasileiros de cardiologia
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journal_title:Arquivos brasileiros de cardiologia
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journal_title:Arquivos brasileiros de cardiologia
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abstract:BACKGROUND:Hypertension is related to increased body fat, which can be evaluated by anthropometric indicators. OBJECTIVE:To determine the predictive power of anthropometric indicators and establish their cutoff points as discriminators of high blood pressure. METHODS:Cross-sectional study with a sample of 660 adolesc...
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abstract:OBJECTIVE:To determine the utility of B-type natriuretic peptide (BNP) in the diagnosis of congestive heart failure (CHF) in patients presenting with dyspnea to an emergency department (ED). METHODS:Seventy patients presenting with dyspnea to an ED from April to July 2001 were included in the study. Mean age was 72+/-...
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journal_title:Arquivos brasileiros de cardiologia
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更新日期:1994-10-01 00:00:00
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journal_title:Arquivos brasileiros de cardiologia
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journal_title:Arquivos brasileiros de cardiologia
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更新日期:1989-03-01 00:00:00
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