Abstract:
BACKGROUND:Chronic heart failure (CHF) is a complex syndrome which comprises structural and functional alterations in the heart in maintaining the adequate blood demand to all tissues. Few investigations sought to evaluate oxidative DNA damage in CHF. OBJECTIVE:To quantify the DNA damage using the comet assay in left ventricle (LV), lungs, diaphragm, gastrocnemius and soleus in rats with CHF. METHODS:Twelve male Wistar rats (300 to 330 g) were selected for the study: Sham (n = 6) and CHF (n = 6). The animals underwent myocardial infarction by the ligation of the left coronary artery. After six weeks, the animals were euthanized. It was performed a cell suspension of the tissues. The comet assay was performed to evaluate single and double strand breaks in DNA. Significance level (p) considered < 0.05. RESULTS:The CHF group showed higher values of left ventricle end-diastolic pressure (LVEDP), pulmonary congestion, cardiac hypertrophy and lower values of maximal positive and negative derivatives of LV pressure, LV systolic pressure (p < 0.05). CHF group showed higher DNA damage (% tail DNA, tail moment and Olive tail moment) compared to Sham (p < 0.001). The tissue with the highest damage was the soleus, compared to LV and gastrocnemius in CHF group (p < 0.05). CONCLUSION:Our results indicates that the CHF affects all tissues, both centrally and peripherically, being more affected in skeletal muscle (soleus) and is positively correlated with LV dysfunction.
journal_name
Arq Bras Cardioljournal_title
Arquivos brasileiros de cardiologiaauthors
Stefani GP,Nunes RB,Rossato DD,Hentschke VS,Domenico MD,Lago PD,Rhoden CRdoi
10.36660/abc.20180198subject
Has Abstractpub_date
2020-02-01 00:00:00pages
234-242issue
2eissn
0066-782Xissn
1678-4170pii
S0066-782X2020000200234journal_volume
114pub_type
杂志文章abstract:BACKGROUND:Percutaneous intervention in patients with bioprosthetic mitral valve dysfunction is an alternative to conventional surgical treatment. OBJECTIVES:To report the first Brazilian experience with transseptal transcatheter bioprosthetic mitral valve-in-valve implantation (transseptal-TMVIV). METHODS:Patients w...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章,多中心研究
doi:10.36660/abc.20190252
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Sudden death is the leading cause of death in Chagas disease (CD), even in patients with preserved ejection fraction (EF), suggesting that destabilizing factors of the arrhythmogenic substrate (autonomic modulation) contribute to its occurrence. OBJECTIVE:To determine baroreflex sensitivity (BRS) in patient...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.5935/abc.20140066
更新日期:2014-06-01 00:00:00
abstract::Coronary artery bypass graft (CABG) is a well established procedure with current precise indications. The advent and spread of this technique was possible after the introduction of the coronary angiogram. Although many evaluation methods have been developed in the past years, to date, none have been able to replace th...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2009000900019
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Patients with end-stage kidney disease (ESKD) experience elevated cardiac stress because of the repetitive and intermittent character of dialysis. Changes in ventricular electrical systole induced by necessary dialysis significantly contribute to predict sudden death due to arrhythmia in ESKD. OBJECTIVE:The...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.5935/abc.20130063
更新日期:2013-03-01 00:00:00
abstract::Central vein cannulation is used as routine for long-time treatment in paediatric intensive care units. The Sylastic catheter is now a days the most common used because of its non-thrombogenic effect. However, in the case here reported, fragmentation during its removal occurred in a eleven month baby. Non surgical rem...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:
更新日期:1989-11-01 00:00:00
abstract::A 61 year-old Chagasic woman, with previous left ventricular systolic disfunction, ventricular tachychardia and cardiac pacemaker, presented cardiac arrest in asystolia after surgical ressection of apical aneurysm. ...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2003001000010
更新日期:2003-08-01 00:00:00
abstract:PURPOSE:To evaluate the efficiency of a non-surgical treatment of the femoral false aneurysm following cardiac catheterization using the color Doppler echocardiography monitorization. METHODS:From August 1993 to October 1996, 17 patients were evaluated by the color Doppler echocardiography, 7 women and 10 men, between...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:
更新日期:1997-06-01 00:00:00
abstract:PURPOSE:To evaluate the nitroglycerin patches efficacy and tolerability in patients with stable angina pectoris. METHODS:One thousand and five hundred and thirty nine patients with stable angina pectoris, mean age 61.0 +/- 10.3, 891 men and 648 women were prospectively evaluated by five hundred and thirty five special...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章,多中心研究
doi:
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND:Left ventricular hypertrophy (LVH) is a marker of increased cardiovascular risk and is frequently associated with both arterial hypertension (AH) and aortic stenosis (AoS). Also, these two maladies may co-exit in a same patient. However, in these cases, it is not clear the impact of each one in LVH. OBJECTI...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2011005000081
更新日期:2011-09-01 00:00:00
abstract::A 32 year old female patient, documented clinically and echocardiographically to have a competent prolapse of the mitral valve (MVP), developed a sudden ischemic cerebrovascular accident (CVA), suggestive of embolism. There were no predisposing factors to cerebrovascular disease, except for past use of contraceptive p...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Stress is defined as a complicated state that related to homeostasis disturbances, over-activity of the sympathetic nervous system and hypothalamus-pituitary-adrenal axis responses. Cardiac preconditioning reduces myocardial damages. OBJECTIVE:This study was designed to assess the cardioprotective effects o...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.5935/abc.20190189
更新日期:2019-10-10 00:00:00
abstract:BACKGROUND:The determination of the prevalence of electrocardiographic alterations in the older age strata of the Brazilian population represents important information with clinical and epidemiological purpose. OBJECTIVE:To verify the prevalence rates of atrial fibrillation, enlarged Q/QS waves (Minnesota code 1.1-1.2...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2009001200015
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Non-invasive cardiological methods have been used for the identification of myocardial damage in Chagas disease. OBJECTIVE:To verify whether the rest/stress myocardial perfusion scintigraphy is able to identify early myocardial damage in the indeterminate form of Chagas disease. METHODS:Eighteen patients w...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2010005000064
更新日期:2010-07-01 00:00:00
abstract:Background:Little has been studied on heart rate and its relationship with metabolic disorders. Objective:To identify possible association between heart rate (HR) and metabolic disorders in children and adolescents. Methods:This cross-sectional study evaluated 2.098 subjects, aged between 7 and 17 years. The variable...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.5935/abc.20170103
更新日期:2017-09-01 00:00:00
abstract::Woman, 67 years old, with unstable angina and history of myocardial revascularization: left internal thoracic artery to anterior descending artery and graft with radial artery (RA) to right coronary artery branches. Coronariography showed stenosis of 90% in the RA graft, treated with conventional stent. After two mont...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2011000400017
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Transvenous lead extraction (TLE) of cardiac implantable electronic devices (CIED) is an uncommon procedure and requires specialized personnel and adequate facilities. OBJECTIVES:To evaluate the effectiveness and safety of the removal of CIED leads and to determine risk factors for surgical complications an...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.36660/abc.20200476
更新日期:2020-12-01 00:00:00
abstract::The patient was a male with myasthenia gravis, hospitalized with acute respiratory failure due to decompensation of the underlying disease. He evolved with findings suggestive of acute myocardial infarction, with electrocardiographic and enzymatic alterations compatible with that diagnosis. The patient underwent emerg...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2005000400013
更新日期:2005-04-01 00:00:00
abstract::[This corrects the article doi: 10.5935/abc.20170140]. ...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章,已发布勘误
doi:10.5935/abc.20180213
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:The advancement of noninvasive imaging methods has resulted in the increase in diagnosis of heart neoplasms. However, the literature has few studies involving primary cardiac neoplasms in children. OBJECTIVE:To retrospectively review cases of primary heart neoplasms in children, considering the initial clin...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.5935/abc.20130024
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:The decrease in mortality due to cardiovascular diseases (CVD) has been achieved in the United States and the same decrease has been happening in developing countries, thanks to favorable changes in lifestyle and risk factors. Despite such consideration, the volume of information available on the distribution...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2005001400005
更新日期:2005-07-01 00:00:00
abstract::The authors report a case of a 65-year-old male patient who, after complaint about retrosternal discomfort and going through a thoracic radiography with mediastinal enlargement, was submitted to magnetic resonance angiography, which detected a right aortic arch with aberrant left subclavian artery and Kommerell divert...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章,评审
doi:10.1590/s0066-782x2009001200026
更新日期:2009-12-01 00:00:00
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journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.5935/abc.20180268
更新日期:2019-03-01 00:00:00
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journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2006001800003
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:In the general population, regular practice of physical exercises is associated with improved physical capacity and reduction of cardiovascular events. Concerning patients with chronic kidney disease, a population with significant impairment of physical capacity and high rates of cardiovascular mortality, fe...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2010005000043
更新日期:2010-06-01 00:00:00
abstract::Fifty eight year old man, with dyspnea, fatigue and progressive angina underwent cinecoronarography, which showed an arterio-venous coronary-pulmonary fistula originating from the circumflex artery to the pulmonary circulation. We decided to occlude it percutaneously, using a detachable balloon technic. The occlusion ...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:
更新日期:1993-03-01 00:00:00
abstract::Despite being relatively recent, a growing and significant accumulation of experimental and clinical evidence has been observed that points to a gradual state of immune-inflammatory activation in patients with heart failure (HF). High levels of several cytokines are found in the circulation and cardiac muscle of indiv...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章,评审
doi:10.1590/s0066-782x2007001500009
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVES:The inhibition of the rennin-angiotensin-aldosterone system (RAAS) and sympathetic autonomous nervous system has increased the perspective of survival in these patients, as well as allowing the improvement of the quality of life. The aim of this study was to evaluate the reality of the treatment employed and...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2007000400018
更新日期:2007-04-01 00:00:00
abstract::Atrial aneurysms involving the free wall or atrial appendage are rare entities in cardiology practice and may be associated with atrial arrhythmias or embolic phenomena. We review the literature and report a case of aneurysm of the right atrial appendage in a young adult, whose diagnosis was established with echocardi...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2002000200013
更新日期:2002-02-01 00:00:00
abstract::There are limited data regarding the use of hypolipidemic agents concomitantly with immunosuppressive drugs. Best evidence is provided for the use of statins and cyclosporine. In terms of pharmacodynamics, these two drugs have different substrates. In respect to pharmacokinetics, statins usually do not modify serum co...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:/S0066-782X2005002400013
更新日期:2005-10-01 00:00:00
abstract::The risk scores used as assistance agents in valve diseases are validated worldwide; however, the data are not homogeneous. The epidemiological characteristics of each population require local validation of these risk tools. The percutaneous valve replacement, which is a reality in valvular diseases (especially aortic...
journal_title:Arquivos brasileiros de cardiologia
pub_type: 杂志文章
doi:10.1590/s0066-782x2012000500018
更新日期:2012-05-01 00:00:00