[Hypolipidemic treatment under special conditions: posttransplant and/or immunosuppressive therapy].

Abstract:

:There are limited data regarding the use of hypolipidemic agents concomitantly with immunosuppressive drugs. Best evidence is provided for the use of statins and cyclosporine. In terms of pharmacodynamics, these two drugs have different substrates. In respect to pharmacokinetics, statins usually do not modify serum concentrations of cyclosporine, however when combined with any statin a careful monitoring of cyclosporine levels is recommended, due to a narrow therapeutic window of the immunosuppressive agent. Conversely, cyclosporine does affect the area under the curve for many statins, by inhibiting the CYP450 3A4, thus increasing systemic exposure to statins. Pravastatin appears to be the safest compound, once it is glucuronized. The area under the curve for the other statins (simvastatin, lovastatin, atorvastatin, cerivastatin, and rosuvastatin) can be increased in variable degrees according to the site of metabolization, liver extraction by OATP-C transporter, biliary secretion, renal excretion, and drug extrusion by the MDR system.

journal_name

Arq Bras Cardiol

authors

Izar MC

doi

/S0066-782X2005002400013

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

50-7

eissn

0066-782X

issn

1678-4170

pii

S0066-782X2005002400013

journal_volume

85 Suppl 5

pub_type

杂志文章
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    doi:

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  • [Effect of dopamine in dopaminergic doses on pulmonary circulation of dogs in normoxia and hypoxia].

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    pub_type: 杂志文章

    doi:

    authors: de Araújo FG,Romaldini H,Bogossian M,Afonso JE,Uehara C

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    journal_title:Arquivos brasileiros de cardiologia

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    doi:

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    journal_title:Arquivos brasileiros de cardiologia

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:

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    pub_type: 杂志文章

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    更新日期:2016-02-01 00:00:00

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

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    pub_type: 杂志文章

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:

    authors: Acha RE,Rezende MT,Guzman Heredia RA,Silva AC,Rezende ES,Souza CA

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章,meta分析,评审

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    更新日期:2010-07-01 00:00:00

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章,评审

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 临床试验,杂志文章

    doi:

    authors: Campagnucci VP,Suzuki HY,Franken RA,Rivetti LA

    更新日期:1994-07-01 00:00:00

  • [Assessment of the Bezold-Jarisch reflex in experimental myocardial infarction].

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:

    authors: Meyrelles SS,Mill JG,Vasquez EC

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  • [Reversion of cardiogenic shock by direct angioplasty of the right coronary artery: a case report].

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:

    authors: Medeiros Filho H,de Medeiros Mde F,de Souza JB,Montenegro S,Mesquita E

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    pub_type: 杂志文章

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1590/s0066-782x2001000400001

    authors: Serro-Azul JB,de Paula RS,Gruppi C,Pinto L,Pierri H,Nussbacher A,Gebara O,Moffa P,Pereira-Barreto AC,Wajngarten M

    更新日期:2001-04-01 00:00:00

  • [Systemic hypertension at emergency units. The use of symptomatic drugs as choice for management].

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章,随机对照试验

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    更新日期:2005-08-01 00:00:00

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.36660/abc.20190231

    authors: Chu T,Huang M,Zhao Z,Ling F,Cao J,Ge J

    更新日期:2020-10-01 00:00:00

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.5935/abc.20170037

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    更新日期:2017-04-01 00:00:00

  • Hypomethylation of Interleukin-6 Promoter is Associated with the Risk of Coronary Heart Disease.

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  • Intrauterine detection of Ebstein's anomaly and Down's syndrome. Prenatal diagnosis of a rare combination.

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    journal_title:Arquivos brasileiros de cardiologia

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    doi:

    authors: Jorge PA,Neyra LC,Ozaki RM,de Almeida E

    更新日期:1997-07-01 00:00:00

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    pub_type: 杂志文章,随机对照试验

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章,评审

    doi:

    authors: Mota VG,Markman Filho B

    更新日期:2013-04-01 00:00:00

  • Predictors of hospital mortality in hemodynamically stable patients with pulmonary embolism.

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章,多中心研究

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    更新日期:2009-08-01 00:00:00