Emerging role of the GH/IGF-I on cardiometabolic control.

Abstract:

:Growth hormone (GH), the main regulator for post-natal growth, has important metabolic actions on different tissues, similar or opposite to insulin like growth factor I (IGF-I), mainly produced by the liver after the binding of GH to its receptor. Experiments with animal models indicate an important role of GH on insulin resistance although the IGF-I role is not yet completely established. In humans, GH promotes an increase on lypolisis and lipid oxidation, while IGF-I leads to an increase on lipid oxidation only in a chronic way. While growth actions are time-limited, metabolic and cardiovascular actions of the GH/IGF-I axis are throughout life. GH anabolic effects have been used on chronic and hypercatabolic conditions, although investigations on the clinical outcomes are still scarce. In this paper, we intend to review GH metabolic actions experienced by animal models, studies with normal humans and GH deficient individuals, individuals with diabetes mellitus type 1 and metabolic syndrome individuals, hypercatabolic states and the relationship between GH and adipokines, endothelial disfunction and atherogenesis.

journal_name

Arq Bras Cardiol

authors

Oliveira CR,Meneguz-Moreno RA,Aguiar-Oliveira MH,Barreto-Filho JA

doi

10.1590/s0066-782x2011001400012

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

434-9

issue

5

eissn

0066-782X

issn

1678-4170

pii

S0066-782X2011001400012

journal_volume

97

pub_type

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