Analysis of plasma homocysteine levels in patients with unstable angina.

Abstract:

OBJECTIVE:To determine the prevalence of hyperhomocystinemia in patients with acute ischemic syndrome of the unstable angina type. METHODS:We prospectively studied 46 patients (24 females) with unstable angina and 46 control patients (19 males), paired by sex and age, blinded to the laboratory data. Details of diets, smoking habits, medication used, body mass index, and the presence of hypertension and diabetes were recorded, as were plasma lipid and glucose levels, C-reactive protein, and lipoperoxidation in all participants. Patients with renal disease were excluded. Plasma homocysteine was estimated using high-pressure liquid chromatography. RESULTS:Plasma homocysteine levels were significantly higher in the group of patients with unstable angina (12.7+/-6.7 micromol/L) than in the control group (8.7+/-4.4 micromol/L) (p<0.05). Among males, homocystinemia was higher in the group with unstable angina than in the control group, but this difference was not statistically significant (14.1+/-5.9 micromol/L versus 11.9+/-4.2 micromol/L). Among females, however, a statistically significant difference was observed between the 2 groups: 11.0+/-7.4 micromol/L versus 6.4+/-2.9 micromol/L (p<0.05) in the unstable angina and control groups, respectively. Approximately 24% of the patients had unstable angina at homocysteine levels above 15 micromol/L. CONCLUSION:High homocysteine levels seem to be a relevant prevalent factor in the population with unstable angina, particularly among females.

journal_name

Arq Bras Cardiol

authors

Tavares JR,D'Almeida V,Diniz DC,Terzi CA,Cruz EN,Stefanini E,Andriollo A,Paola AA,Carvalho AC

doi

10.1590/s0066-782x2002001100008

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

161-72

issue

2

eissn

0066-782X

issn

1678-4170

pii

S0066-782X2002001100008

journal_volume

79

pub_type

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