Prognostic factors in Wegener's granulomatosis.

Abstract:

:We analysed data from 64 patients with Wegener's granulomatosis to determine predictor variables of outcome. The mean period of observation after the diagnosis had been established was 3.2 (range 0.1-11.2) years. At the time of diagnosis, 15 (23%) patients had only local symptoms. The disease was generalized to multiple organs in 49 (77%) patients. Renal biopsies were obtained in 33 patients; 13 (39%) had extracapillary glomerulonephritis, which was the most common renal lesion. All but three patients received immunosuppressive therapy. At time of follow-up, 17 (27%) patients were in complete, and 26 (40%) in partial remission. We employed a Kaplan Meier analysis to identify predictor variables of outcome. Renal involvement, initial creatinine concentration, serum albumin or total protein concentration, leukocyte count and erythrocyturia proved to be predictor variables. These variables may be of value in guiding the intensity of treatment in patients with Wegener's granulomatosis.

journal_name

Postgrad Med J

authors

Briedigkeit L,Kettritz R,Göbel U,Natusch R

doi

10.1136/pgmj.69.817.856

subject

Has Abstract

pub_date

1993-11-01 00:00:00

pages

856-61

issue

817

eissn

0032-5473

issn

1469-0756

journal_volume

69

pub_type

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