Evaluation of DNA ploidy in endometrial cancer.


:We performed a study to evaluate the relationships between the surgical stage (FIGO, 1989), histological tumor grade, myometrial invasion, peritoneal cytology, lymph node metastasis and prognosis, and DNA ploidy determined by flow cytometry in paraffin-embedded blocks of resected cancer lesions from 76 patients with uterine corpus cancer (adenocarcinoma endometrial type) who had been surgically treated in our hospital. The coefficient of variation was 5.00% on average (3.40 to 5.30%) in DNA histograms of the 76 patients. DNA aneuploid was detected in 18 patients (24%) and tended to be more frequently found in association with advanced surgical stage, higher histological tumor grade, deeper myometrial invasion, positive lymph node metastasis, and positive peritoneal cytology. Kaplan-Meier method was used to analyze the relationship between prognosis and DNA ploidy in 76 patients with uterine corpus cancer, in 36 with surgical stage III, and in 26 with surgical stage IIIa, resulting in prognosis which was significantly better in patients with DNA diploid. The results of multivariate analysis also indicate that DNA ploidy is an independent prognostic factor of uterine corpus cancer. These results suggest that DNA ploidy should be an important parameter for predicting prognosis of uterine corpus cancer.


Gynecol Oncol


Gynecologic oncology


Ikeda M,Watanabe Y,Nanjoh T,Noda K




Has Abstract


1993-07-01 00:00:00














  • Fulminant course of a microinvasive vulvar carcinoma in an immunosuppressed woman.

    abstract::Iatrogenic immune suppression following renal transplantation is frequently associated with certain neoplasms, including vulvar carcinoma. We describe a patient with a vulvar carcinoma less than 1 mm depth of invasion and less than 3 mm superficial spread 12 years after renal transplantation. A simple vulvectomy was p...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Volgger B,Marth C,Zeimet A,Müller-Holzner E,Ruth N,Dapunt O

    更新日期:1997-04-01 00:00:00

  • Prognostic significance of peritoneal cytology in low-intermediate risk endometrial cancer.

    abstract:OBJECTIVES:There is uncertainty surrounding the prognostic value and clinical utility of peritoneal cytology in endometrial cancer. Our primary objective was to determine if positive cytology is associated with disease-free and overall survival in women treated surgically for endometrial cancer, specifically those with...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Scott SA,van der Zanden C,Cai E,McGahan CE,Kwon JS

    更新日期:2017-05-01 00:00:00

  • Does the interval from primary surgery to chemotherapy influence progression-free survival in ovarian cancer?

    abstract:OBJECTIVES:The objective of this study was to determine whether the length of the interval from primary surgery to commencement of chemotherapy has any direct effect on progression-free survival in ovarian cancer. METHODS:The progression-free survival of 472 patients enrolled in four trials who had all received platin...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Flynn PM,Paul J,Cruickshank DJ,Scottish Gynaecological Cancer Trials Group.

    更新日期:2002-09-01 00:00:00

  • Brain metastases in patients with EOC: Clinico-pathological and prognostic factors. A multicentric retrospective analysis from the MITO group (MITO 19).

    abstract:BACKGROUND:Brain metastases (BM) from epithelial ovarian cancer (EOC) are considered a rare and unfavourable event. There is no consensus regarding the best management of these patients. METHODS:A multicenter retrospective analysis of patients with BM from EOC treated between 1997 and 2014 in 18 institutions of the MI...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Marchetti C,Ferrandina G,Cormio G,Gambino A,Cecere S,Lorusso D,De Giorgi U,Bogliolo S,Fagotti A,Mammoliti S,Narducci F,Bergamini A,Scollo P,Biglia N,Breda E,Tamberi S,Marinaccio M,Angioli R,Salerno L,Eusebi MC,Loi

    更新日期:2016-12-01 00:00:00

  • Evaluating class III antiarrhythmic agents as novel MYC targeting drugs in ovarian cancer.

    abstract:OBJECTIVE:To evaluate the utility of amiodarone and its derivative dronedarone as novel drug repositioning candidates in EOC and to determine the potential pathways targeted by these drugs. METHODS:Drug-predict bioinformatics platform was used to assess the utility of amiodarone as a novel drug-repurposing candidate i...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Belur Nagaraj A,Joseph P,Kovalenko O,Wang Q,Xu R,DiFeo A

    更新日期:2018-12-01 00:00:00

  • Regulation of the metastasis suppressor gene MKK4 in ovarian cancer.

    abstract:OBJECTIVES:MKK4 is a metastasis suppressor that is downregulated in some ovarian cancers. We sought to investigate whether promoter methylation, loss of heterozygosity, or changes in phosphorylation are involved in MKK4 dysregulation during ovarian carcinogenesis. METHODS:Bisulfite sequencing was used to determine MKK...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Spillman MA,Lacy J,Murphy SK,Whitaker RS,Grace L,Teaberry V,Marks JR,Berchuck A

    更新日期:2007-05-01 00:00:00

  • DNA ploidy, nuclear size, proliferation index and DNA-hypomethylation in ovarian cancer.

    abstract:OBJECTIVE:The present study was undertaken to analyze the impact of epigenetic alterations with a main focus on nuclear area, aneuploidy, hyperploidy, and proliferation in 70 ovarian cancer specimens. METHODS:Morphometric changes and somatic chromosomal ploidy status were assessed by Feulgen spectrophotometry. DNA-hyp...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Zeimet AG,Fiegl H,Goebel G,Kopp F,Allasia C,Reimer D,Steppan I,Mueller-Holzner E,Ehrlich M,Marth C

    更新日期:2011-04-01 00:00:00

  • Detection of endometrial cancer cells in the fallopian tube lumen is associated with adverse prognostic factors and reduced survival.

    abstract:OBJECTIVE:Stage is a critical determinant of prognosis and treatment for endometrial cancer (EC) patients. Women who have had a tubal ligation for sterilization have improved EC survival, secondary to lower stage at presentation, suggesting that transtubal spread may represent an important route of metastasis. We evalu...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Felix AS,Sinnott JA,Vetter MH,Rhoades J,Cohn DE,Backes FJ,Sherman ME,Suarez AA

    更新日期:2018-07-01 00:00:00

  • Recurrent and persistent squamous cell cervical carcinoma in women under age 35.

    abstract::Forty-five patients with invasive cervical squamous cell carcinoma were registered in the Tom Baker Cancer Centre from 1980 to 1985. The natural history of 22 patients (48.9%) who developed persistent or recurrent disease including 11 Stage IB, 8 Stage IIB, and 3 Stage IIIB is reported. Only one patient who had the un...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Stuart GC,Robertson DI,Fedorkow DM,Duggan MA,Nation JG

    更新日期:1988-06-01 00:00:00

  • Clear cell carcinoma of the ovary: a study of 59 cases.

    abstract::Clear cell carcinoma of the ovary accounts for 2 to 3% of all epithelial ovarian neoplasms. Patient profiles, pathological characteristics, and results of treatment are reviewed for 59 patients. The median age was 51. Disease extent at diagnosis was as follows: stage I, 18 patients (31%); stage II, 20 patients (34%); ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Crozier MA,Copeland LJ,Silva EG,Gershenson DM,Stringer CA

    更新日期:1989-11-01 00:00:00

  • Frailty: an outcome predictor for elderly gynecologic oncology patients.

    abstract:OBJECTIVES:The objective of this pilot study was to determine if frailty predicts surgical complications among elderly women undergoing gynecologic oncology procedures. METHODS:A cohort of gynecologic oncology patients age ≥ 65, undergoing surgery between March and December 2011 was identified. Frailty was evaluated u...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Courtney-Brooks M,Tellawi AR,Scalici J,Duska LR,Jazaeri AA,Modesitt SC,Cantrell LA

    更新日期:2012-07-01 00:00:00

  • A population-based study of causes of death after endometrial cancer according to major risk factors.

    abstract:OBJECTIVE:To identify the most common causes of death and potentially modifiable risk factors in endometrial cancer patients. METHODS:745 women diagnosed with incident endometrial cancer were enrolled in a population-based study from 1991 to 1994. Participants completed structured interviews about 1 year after diagnos...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Lees B,Hampton JM,Trentham-Dietz A,Newcomb P,Spencer R

    更新日期:2021-01-06 00:00:00

  • Bleomycin, vincristine, mitomycin-C, and cisplatin in the management of gynecological squamous cell carcinomas.

    abstract::Twenty-one patients with squamous carcinoma of the genital tract were treated with bleomycin, Oncovin, mitomycin-C, and cisplatin (BOMP). Six patients received BOMP as primary therapy. Five of six responded with one patient having an autopsy-proven complete response after treatment for a disseminated adenosquamous car...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Belinson JL,Stewart JA,Richards AL,McClure M

    更新日期:1985-03-01 00:00:00

  • Breast cancer followed by corpus cancer: is there a higher risk for aggressive histologic subtypes?

    abstract:OBJECTIVE:To analyze corpus cancer patients with a breast cancer history for risk of developing aggressive uterine histologic types. METHODS:Corpus cancer patients with a history of breast cancer were identified from the Surveillance Epidemiology and End Results database from 1988 to 2001. Demographics, clinico-pathol...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Chan JK,Manuel MR,Cheung MK,Osann K,Husain A,Teng NN,Rao A,Carlson RW,Whittemore AS

    更新日期:2006-09-01 00:00:00

  • Phase II trial of intraperitoneal cisplatin with intravenous doxorubicin and cyclophosphamide in previously untreated patients with advanced ovarian cancer-long-term follow-up.

    abstract::Forty-three patients with ovarian cancer were entered on this trial and treated with intravenous (iv) cyclophosphamide (C) and doxorubicin (A), and intraperitoneal (ip) cisplatin (DDP), every 21 days for eight cycles. Following iv hydration, the cisplatin was administered through an intraperitoneal catheter in 2 L of ...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章


    authors: Morgan RJ Jr,Braly P,Cecchi G,Leong L,Shibata S,Margolin K,Somlo G,McNamara M,Longmate J,Schinke S,Raschko J,Nagasawa S,Kogut N,Parker P,Stein A,Cho J,Smith E,Coluzzi P,Najera L,Johnson D,Womack E,Doroshow JH

    更新日期:1999-12-01 00:00:00

  • Para-aortic lymphadenectomy may improve disease-related survival in patients with multipositive pelvic lymph node stage IIIc endometrial cancer.

    abstract:OBJECTIVE:The purpose of this study was to determine whether para-aortic lymphadenectomy improves disease-related survival (DRS) in stage IIIc endometrial cancer. METHODS:A total of 63 patients with stage IIIc endometrial carcinoma underwent primary radical surgery in the Tohoku Gynecologic Cancer Unit from 1993 to 20...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Fujimoto T,Nanjyo H,Nakamura A,Yokoyama Y,Takano T,Shoji T,Nakahara K,Yamada H,Mizunuma H,Yaegashi N,Sugiyama T,Kurachi H,Sato A,Tanaka T

    更新日期:2007-11-01 00:00:00

  • A phase II study of Hsp-7 (SGN-00101) in women with high-grade cervical intraepithelial neoplasia.

    abstract:OBJECTIVE:Approximately 2 million women worldwide are infected with high-risk human papillomaviruses (HPV), resulting in a substantial risk for the development of invasive lower genital malignancies. This study was undertaken to determine the effects of vaccination with a protein encoding a bacterial heat shock protein...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Roman LD,Wilczynski S,Muderspach LI,Burnett AF,O'Meara A,Brinkman JA,Kast WM,Facio G,Felix JC,Aldana M,Weber JS

    更新日期:2007-09-01 00:00:00

  • Traditional and nontraditional histopathologic predictors of recurrence in uterine endometrioid adenocarcinoma.

    abstract::Ninety-three consecutive operative cases of myometrial invasive endometrioid adenocarcinoma of the uterus without evidence of extrauterine spread at surgery were reviewed to determine whether any histopathologic features other than those traditionally reported might predict recurrence. Recurrence was associated with t...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Lee KR,Vacek PM,Belinson JL

    更新日期:1994-07-01 00:00:00

  • A modified incision and technique for total retroperitoneal access and lymph node dissection.

    abstract::Surgical assessment of aortocaval lymph nodes in patients with unresectable primary cervical cancer helps in planning radiation treatment ports. Removal of enlarged lymph nodes may also serve a therapeutic purpose in reducing the tumor load to be sterilized by radiation. An extraperitoneal dissection is considered to ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Vasilev SA

    更新日期:1995-02-01 00:00:00

  • Urinary mesothelin provides greater sensitivity for early stage ovarian cancer than serum mesothelin, urinary hCG free beta subunit and urinary hCG beta core fragment.

    abstract:OBJECTIVES:Early detection of ovarian cancer should improve overall survival. Multiple serum markers have been evaluated as possible tests to detect early stage disease, but few urine markers have been studied. Mesothelin has been detected in serum from patients with ovarian cancer, but has not been previously reported...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Badgwell D,Lu Z,Cole L,Fritsche H,Atkinson EN,Somers E,Allard J,Moore RG,Lu KH,Bast RC Jr

    更新日期:2007-09-01 00:00:00

  • Sensitivity to Fas-mediated apoptosis in high-risk HPV-positive human cervical cancer cells: relationship with Fas, caspase-8, and Bid.

    abstract:OBJECTIVE:Binding of Fas ligand or agonistic anti-Fas antibody to the death receptor Fas can activate a caspase-cascade resulting in apoptosis. In the present study, the functionality of the Fas pathway was studied in human cervical cancer cells with different HPV and p53 status. METHODS:HeLa (HPV-18 positive), CaSki,...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Hougardy BM,van der Zee AG,van den Heuvel FA,Timmer T,de Vries EG,de Jong S

    更新日期:2005-05-01 00:00:00

  • Low risk of complications associated with the fenestrated peritoneal catheter used for intraperitoneal chemotherapy in ovarian cancer.

    abstract:OBJECTIVES:We previously reported a 10% rate of catheter complications, including inflow obstruction and infection, using a fenestrated catheter to administer intraperitoneal (i.p.) chemotherapy for ovarian cancer. Because of recent reports of higher rates of catheter complications, we performed this study to update ou...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Black D,Levine DA,Nicoll L,Chou JF,Iasonos A,Brown CL,Sonoda Y,Chi DS,Leitao MM,Abu-Rustum NR,Ferguson SE,Barakat RR

    更新日期:2008-04-01 00:00:00

  • Predictive and prognostic angiogenic markers in a gynecologic oncology group phase II trial of bevacizumab in recurrent and persistent ovarian or peritoneal cancer.

    abstract:OBJECTIVE:Potential predictive/prognostic angiogenic markers were prospectively examined in a phase II trial of bevacizumab in epithelial ovarian cancer (EOC)/primary peritoneal cancer (PPC). METHODS:Recurrent/persistent EOC/PPC patients were treated with bevacizumab (15 mg/kg IV q21days) until disease progression. Va...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Han ES,Burger RA,Darcy KM,Sill MW,Randall LM,Chase D,Parmakhtiar B,Monk BJ,Greer BE,Connelly P,Degeest K,Fruehauf JP

    更新日期:2010-12-01 00:00:00

  • Detection and quantitation of human papillomavirus type 16, 18 and 52 DNA in the peripheral blood of cervical cancer patients.

    abstract:OBJECTIVE:To prospectively evaluate the feasibility of detecting human papillomavirus (HPV) type 16, 18 and 52 DNA in the peripheral blood of patients with cervical cancer using real-time polymerase chain reaction (PCR) and to determine its prognostic importance. METHODS:Blood and cervical swab specimens from 135 cons...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Ho CM,Yang SS,Chien TY,Huang SH,Jeng CJ,Chang SF

    更新日期:2005-12-01 00:00:00

  • The NCI-MATCH trial and precision medicine in gynecologic cancers.

    abstract::The Precision Medicine Initiative is a National Cancer Institute (NCI) driven interdisciplinary collaborative effort to test the feasibility of trials incorporating genomic profiling when choosing patient therapies. The goal of the initiative is to generate the scientific evidence needed to move the concept of precisi...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Barroilhet L,Matulonis U

    更新日期:2018-03-01 00:00:00

  • The anterior Obturator Artery Perforator (aOAP) flap: surgical anatomy and application of a method for vulvar reconstruction.

    abstract:OBJECTIVE:Vulvar reconstruction following oncologic resection is challenging. Some flaps used for reconstruction can show adverse characteristics such as excessive tissue bulk or increased distance to the defect. Region of the sulcus genitofemoralis is of thin and pliable tissue proximate to the vulva. Vasculature and ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: O'Dey DM,Bozkurt A,Pallua N

    更新日期:2010-12-01 00:00:00

  • Photodynamic therapy using topically applied dihematoporphyrin ether in the treatment of cervical intraepithelial neoplasia.

    abstract:OBJECTIVE:To perform a phase I study of topically applied dihematoporphyrin ether (DHE) in the photodynamic treatment (PDT) of cervical intraepithelial neoplasia (CIN) using fixed DHE doses and application schedules, and a variable dose of 630 nm red light delivered by an argon-pumped dye laser. METHODS:Between Februa...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章


    authors: Monk BJ,Brewer C,VanNostrand K,Berns MW,McCullough JL,Tadir Y,Manetta A

    更新日期:1997-01-01 00:00:00

  • Lymphopenia and its association with survival in patients with locally advanced cervical cancer.

    abstract:OBJECTIVE:To evaluate the association between lymphopenia and survival in women with cervical cancer treated with primary chemoradiation. METHODS:A single institution, retrospective analysis of patients with stage IB2-IVA cervical cancer who received upfront chemoradiation from 1998 to 2013 was performed. Complete blo...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Wu ES,Oduyebo T,Cobb LP,Cholakian D,Kong X,Fader AN,Levinson KL,Tanner EJ 3rd,Stone RL,Piotrowski A,Grossman S,Roche KL

    更新日期:2016-01-01 00:00:00

  • High-dose-rate brachytherapy for medically inoperable stage I endometrial cancer.

    abstract:PURPOSE:The objective of this study was to determine the efficacy of high-dose-rate (HDR) brachytherapy in 36 medically inoperable patients with stage I endometrial cancer. METHODS AND MATERIALS:From October 1989 to August 1997, 36 patients presented with clinical stage I inoperable endometrial cancer. Surgery was pre...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Nguyen TV,Petereit DG

    更新日期:1998-11-01 00:00:00

  • Interphase AgNOR quantity and DNA content in endometrial adenocarcinoma.

    abstract::The relationship between the amount of silver-stained nucleolar organizer regions (AgNORs) and the DNA content of interphase neoplastic cells in 63 cases of human endometrial adenocarcinoma was studied. Interphase AgNOR content was determined as the mean AgNOR area per nucleus by image cytometry in silver-stained samp...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Trerè D,Melchiorri C,Chieco P,Marabini A,Derenzini M

    更新日期:1994-05-01 00:00:00