Fallopian tube abnormalities in uterine serous carcinoma.


OBJECTIVE:Uterine serous carcinoma (USC) is presumed to arise from endometrial intra-epithelial carcinoma (EIC), whereas tubo-ovarian high-grade serous carcinomas have similar precursor lesions in the Fallopian tube, i.e. serous tubal intra-epithelial carcinoma (STIC). The presence of Fallopian tube abnormalities and their clonal relationship to the concurrent USC was investigated. METHODS:In this multicenter study, all patients treated for USC between 1992 and 2017 were retrospectively identified. Histopathological diagnosis of USC, EIC and STIC was revised by an expert pathologist. Additionally, all Fallopian tube sections were immunohistochemically stained (p53 and Ki-67). Fallopian tube abnormalities were classified as either p53 signature, serous tubal intra-epithelial lesion (STIL) or STIC. The USCs and Fallopian tube abnormalities were analyzed by targeted next-generation sequencing. RESULTS:In 168 included patients, Fallopian tube abnormalities were found in 27.4% (46/168): p53-signatures in 17.9% (30/168), STILs in 3.0% (5/168) and STICs in 6.5% (11/168). In subgroup analysis, STICs were found in 9.5% (11/115) of patients with at least one section of the fimbriated end embedded. Next-generation sequencing showed identical TP53-mutations in the STIC and corresponding USC. CONCLUSIONS:In conclusion, the presence of Fallopian tube abnormalities was shown in a high percentage of patients with USC, representing either true precursor lesions or metastasized disease.


Gynecol Oncol


Gynecologic oncology


Steenbeek MP,Bulten J,Snijders MPLM,Lombaers M,Hendriks J,van den Brand M,Kraayenbrink AA,Massuger LFAG,Sweegers S,de Hullu JA,Pijnenborg JMA,Küsters-Vandevelde HVN,Reijnen C




Has Abstract


2020-08-01 00:00:00














  • Stage IB carcinoma of the cervix with lymph node metastases.

    abstract::From January 1, 1946, through January 1, 1986, at the University of Michigan, 60 patients were treated with Stage IB (FIGO) carcinoma of the cervix with lymph node metastases. Clinical variables were examined with regard to long-term survival. Prognostically significant variables were (1) highest level of lymph node i...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Terada KY,Morley GW,Roberts JA

    更新日期:1988-11-01 00:00:00

  • Proteomic analysis of stage I endometrial cancer tissue: identification of proteins associated with oxidative processes and inflammation.

    abstract:OBJECTIVE:The present study aimed to identify differentially expressed proteins employing a high resolution mass spectrometry (MS)-based proteomic analysis of endometrial cancer cells harvested using laser microdissection. METHODS:A differential MS-based proteomic analysis was conducted from discrete epithelial cell p...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Maxwell GL,Hood BL,Day R,Chandran U,Kirchner D,Kolli VS,Bateman NW,Allard J,Miller C,Sun M,Flint MS,Zahn C,Oliver J,Banerjee S,Litzi T,Parwani A,Sandburg G,Rose S,Becich MJ,Berchuck A,Kohn E,Risinger JI,Conrad

    更新日期:2011-06-01 00:00:00

  • Epigenetics of ovarian cancer: from the lab to the clinic.

    abstract:OBJECTIVE:Ovarian cancer remains the most lethal gynaecological cancer. Various molecular changes have been identified and have shown promise for their diagnostic, prognostic and curative capacity but still need further validation. Among different mechanisms, the present article reviews the importance of epigenetic cha...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,评审


    authors: Asadollahi R,Hyde CA,Zhong XY

    更新日期:2010-07-01 00:00:00

  • Phase II trial of etoposide in leiomyosarcoma of the uterus: a Gynecologic Oncology Group study.

    abstract::Twenty-eight patients with advanced, persistent or recurrent leiomyosarcoma of the uterus not previously exposed to cytotoxic drugs were entered into a study of single-agent intravenous etoposide 100 mg/m2 daily for 3 days every 3 weeks. No complete or partial responses were observed. Thirteen patients demonstrated st...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章


    authors: Thigpen T,Blessing JA,Yordan E,Valea F,Vaccarello L

    更新日期:1996-10-01 00:00:00

  • Involvement of the spleen in ovarian adenosquamous carcinoma.

    abstract::Classification of ovarian tumors according to FIGO does not take into account involvement of spleen. A patient who appears to be the first reported case of widespread carcinoma of the ovary with involvement of the splenic parenchyma is presented. ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Glezerman M,Yanai-Inbar I,Charuzi I,Katz M,Glasner M,Piura B

    更新日期:1988-05-01 00:00:00

  • Relationships between c-Ki-ras mutations, HPV types, and prognostic indicators in invasive endocervical adenocarcinomas.

    abstract:OBJECTIVE:Ras gene mutations have been identified in squamous cell carcinomas of the cervix and are associated with advanced-stage tumors. The current study was designed to determine the prevalence of c-Ki-ras mutations in invasive endocervical adenocarcinomas and associations between mutations, HPV status, and known p...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Koulos JP,Wright TC,Mitchell MF,Silva E,Atkinson EN,Richart RM

    更新日期:1993-03-01 00:00:00

  • Pretreatment serum levels of CA-125, carcinoembryonic antigen, tissue polypeptide antigen, and placental alkaline phosphatase in patients with ovarian carcinoma: influence of histological type, grade of differentiation, and clinical stage of disease.

    abstract::Pretreatment serum levels of the tumor-associated antigens CA-125, tissue polypeptide antigen (TPA), carcinoembryonic antigen (CEA), and placental alkaline phosphatase (PLAP) were analyzed in 142 patients with epithelial ovarian carcinoma, and related to clinical and histopathological parameters. In a linear multiple ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Tholander B,Taube A,Lindgren A,Sjöberg O,Stendahl U,Tamsen L

    更新日期:1990-10-01 00:00:00

  • POSTN/TGFBI-associated stromal signature predicts poor prognosis in serous epithelial ovarian cancer.

    abstract:OBJECTIVE:To identify molecular prognosticators and therapeutic targets for high-grade serous epithelial ovarian cancers (EOCs) using genetic analyses driven by biologic features of EOC pathogenesis. METHODS:Ovarian tissue samples (n = 172; 122 serous EOCs, 30 other EOCs, 20 normal/benign) collected prospectively from...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Karlan BY,Dering J,Walsh C,Orsulic S,Lester J,Anderson LA,Ginther CL,Fejzo M,Slamon D

    更新日期:2014-02-01 00:00:00

  • How accurate is frozen section histology of pelvic lymph nodes in patients with endometrial cancer?

    abstract:OBJECTIVE:Recent prospective data support the trend towards systematic retroperitoneal lymphadenectomy in patients with high-risk endometrial cancer. Because para-aortic node involvement in the absence of pelvic node involvement is uncommon, a reliable finding of negative pelvic lymph nodes (PLN) at intraoperative froz...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Pristauz G,Bader AA,Regitnig P,Haas J,Winter R,Tamussino K

    更新日期:2009-10-01 00:00:00

  • Protease-activated receptor-2 (PAR-2) in cervical cancer proliferation.

    abstract:OBJECTIVE:Protease-activated receptor-2 (PAR-2) is a G-protein-coupled receptor that is cleaved and activated by trypsin and tryptase. There is evidence that PAR-2 contributes to tumor progression in stomach, colon, pancreas, prostate and breast cancer patients. However, the role of PAR-2 in cervical cancer is still un...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Sánchez-Hernández PE,Ramirez-Dueñas MG,Albarran-Somoza B,García-Iglesias T,del Toro-Arreola A,Franco-Topete R,Daneri-Navarro A

    更新日期:2008-01-01 00:00:00

  • 10-Gy single-fraction pelvic irradiation for palliation and life prolongation in patients with cancer of the cervix and corpus uteri.

    abstract:OBJECTIVE:The goal of this study was to evaluate the effects of single fractions of 10 Gy pelvic irradiation for palliation and life prolongation in patients with cancer of the uterine cervix or corpus. METHODS:A retrospective analysis was performed on 37 cervical cancer and 27 corpus cancer patients treated in the pe...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Onsrud M,Hagen B,Strickert T

    更新日期:2001-07-01 00:00:00

  • Evaluation of DNA ploidy in endometrial cancer.

    abstract::We performed a study to evaluate the relationships between the surgical stage (FIGO, 1989), histological tumor grade, myometrial invasion, peritoneal cytology, lymph node metastasis and prognosis, and DNA ploidy determined by flow cytometry in paraffin-embedded blocks of resected cancer lesions from 76 patients with u...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Ikeda M,Watanabe Y,Nanjoh T,Noda K

    更新日期:1993-07-01 00:00:00

  • Anatomic identification and functional outcomes of the nerve sparing Okabayashi radical hysterectomy.

    abstract:OBJECTIVES:To clarify the anatomy necessary for the nerve sparing Okabayashi's radical hysterectomy, we meticulously separated the blood vessels and connective tissues to preserve the pelvic splanchnic nerve, the hypogastric nerve, and the bladder branch of the inferior hypogastric plexus under magnification (x2.5) dur...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Fujii S,Takakura K,Matsumura N,Higuchi T,Yura S,Mandai M,Baba T,Yoshioka S

    更新日期:2007-10-01 00:00:00

  • PEBA regimen (cisplatin, etoposide, bleomycin, and adriamycin) in the treatment of drug-resistant choriocarcinoma.

    abstract::Twenty-six drug-resistant choriocarcinoma patients were treated with a PEBA regimen (cisplatin, etoposide, bleomycin, and adriamycin), supplemented by radiotherapy or surgery, from January 1988 to June 1992. A total of 80.8% of the patients had received at least four drugs, and 69.2% had received six or more cycles of...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Chen LP,Cai SM,Fan JX,Li ZT

    更新日期:1995-02-01 00:00:00

  • The prognostic significance of surgical staging for carcinoma of the endometrium.

    abstract::This study is based on a retrospective review of 156 patients with endometrial carcinoma from 1978 through 1984 who underwent primary surgical evaluation. All cases were retrospectively restaged using the newly adopted FIGO surgical staging. The preoperative FIGO clinical stage distribution for this study was as follo...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Wolfson AH,Sightler SE,Markoe AM,Schwade JG,Averette HE,Ganjei P,Hilsenbeck SG

    更新日期:1992-05-01 00:00:00

  • Prognostic significance of c-erB-2 mRNA in ovarian carcinoma.

    abstract::The oncogene specific mRNA of c-erbB-2 was detected by the S1 nuclease protection assay in 95 ovarian cancer specimens. In 79 primary carcinomas, we found 16 (20%) with strong expression, 13 (17%) with weak expression, 4 (5%) with very weak expression, and 46 (58%) with no expression. In 3 of 16 recurrencies (19%) a s...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Tanner B,Kreutz E,Weikel W,Meinert R,Oesch F,Knapstein PG,Becker R

    更新日期:1996-08-01 00:00:00

  • Effects of beta-carotene and other factors on outcome of cervical dysplasia and human papillomavirus infection.

    abstract::Women with histopathologically confirmed cervical intraepithelial neoplasia (CIN) were followed at 3-month intervals in a randomized double-blinded trial to evaluate the efficacy of beta-carotene to cause regression of CIN. Questionnaire data, plasma levels of micronutrients, and a cervicovaginal lavage for human papi...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Romney SL,Ho GY,Palan PR,Basu J,Kadish AS,Klein S,Mikhail M,Hagan RJ,Chang CJ,Burk RD

    更新日期:1997-06-01 00:00:00

  • The performance of Dynamic Spectral Imaging colposcopy depends on indication for referrals.

    abstract::OBJECTIVE. A previous study has shown that Dynamic Spectral Imaging (DSI) colposcopy increases the sensitivity of the colposcopic examination in women referred with abnormal cytology. In this study we have reanalyzed the performance of DSI and conventional colposcopy for new referral conditions and for low-grade cytol...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Louwers JA,Zaal A,Kocken M,Berkhof J,Papagiannakis E,Snijders PJ,Meijer CJ,Verheijen RH

    更新日期:2015-12-01 00:00:00

  • Comorbidity is an independent prognostic factor for the survival of ovarian cancer: a Danish register-based cohort study from a clinical database.

    abstract:OBJECTIVE:The aim of the study was to examine whether comorbidity is an independent prognostic factor for 3129 women diagnosed with ovarian cancer from 2005 to 2011. As Performance status (PS) might capture the impact of comorbidity we addressed whether comorbidity can be explained by PS or whether comorbidity has an i...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Sperling C,Noer MC,Christensen IJ,Nielsen ML,Lidegaard Ø,Høgdall C

    更新日期:2013-04-01 00:00:00

  • Tumor diameter as a predictor of lymphatic dissemination in endometrioid endometrial cancer.

    abstract:OBJECTIVES:To assess the utility of tumor diameter (TD) for predicting lymphatic dissemination (LD) and determining need for lymphadenectomy following diagnosis of endometrioid endometrial cancer. METHODS:Patients diagnosed with stage I-III endometrioid endometrial cancer during 2003-2013 who underwent pelvic or para-...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Cox Bauer CM,Greer DM,Kram JJF,Kamelle SA

    更新日期:2016-05-01 00:00:00

  • Neurotropic desmoplastic melanoma: a rare vulvar malignancy.

    abstract::Melanoma represents the second most frequent vulvar malignancy, and yet is still considered to be an uncommon neoplasm. Several varieties of melanoma exist. A patient who was diagnosed with a rare subtype of melanoma as a primary vulvar process is presented here. To date, there is only one other reported case of neuro...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Byrne PR,Maiman M,Mikhail A,Harris M,Rosen Y

    更新日期:1995-02-01 00:00:00

  • Brain metastasis in epithelial ovarian cancer by BRCA1/2 mutation status.

    abstract:OBJECTIVE:To evaluate clinical outcomes of patients with BRCA-associated ovarian cancer who developed brain metastases (BM). METHODS:Patients with epithelial ovarian, fallopian tube, and primary peritoneal cancer (EOC) and BM, treated at a single institution from 1/1/2008-7/1/2018, were identified from two institution...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Stasenko M,Cybulska P,Feit N,Makker V,Konner J,O'Cearbhaill RE,Alektiar KM,Beal K,Gardner GJ,Long Roche KC,Sonoda Y,Chi DS,Zivanovic O,Leitao MM Jr,Cadoo KA,Tew WP

    更新日期:2019-07-01 00:00:00

  • The additional value of endometrial sampling in the early detection of endometrial cancer in women with Lynch syndrome.

    abstract:OBJECTIVE:Based on previous studies, standard gynecological screening consisting of annual transvaginal ultrasonography (TVU) was added with endometrial sampling in women with Lynch syndrome (LS). The aim of this study was to evaluate the additional value of endometrial sampling in detecting (pre)malignancies of the en...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Helder-Woolderink JM,De Bock GH,Sijmons RH,Hollema H,Mourits MJ

    更新日期:2013-11-01 00:00:00

  • Analysis of outcomes and prognostic factors after fertility-sparing surgery in malignant ovarian germ cell tumors.

    abstract:OBJECTIVE:To evaluate the oncologic and reproductive outcomes and to analyze prognostic factors after fertility-sparing surgery in patients with early and advanced malignant ovarian germ cell tumors (MOGCTs). METHODS:This study included 171 patients who underwent fertility-sparing surgery. Data were gathered from pati...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Park JY,Kim DY,Suh DS,Kim JH,Kim YM,Kim YT,Nam JH

    更新日期:2017-06-01 00:00:00

  • Vascular endothelial growth factor (VEGF) up-regulates epidermal growth factor receptor (EGF-R) in cervical cancer in vitro: this action is mediated through HPV-E6 in HPV-positive cancers.

    abstract:OBJECTIVES:Epidermal Growth Factor Receptor (EGF-R) up-regulation in cervical cancer cells leads to an increase in cell proliferative Insulin-like Growth Factor II (IGF-II) and Vascular Endothelial Growth Factor (VEGF) and a decrease of the anti-proliferative IGF-binding protein-3 (IGF-BP3). The objectives for this stu...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Mathur RS,Mathur SP

    更新日期:2005-04-01 00:00:00

  • Vaginal reconstruction at the time of pelvic exenteration: a surgical and psychosexual analysis of techniques.

    abstract:OBJECTIVES:Vaginal reconstruction following pelvic exenteration is an important aspect of the physical and psychological rehabilitation of women after radical surgery for pelvic malignancies. The choice of techniques is vast, and proper patient and surgical selection is important for obtaining satisfactory functional a...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Mirhashemi R,Averette HE,Lambrou N,Penalver MA,Mendez L,Ghurani G,Salom E

    更新日期:2002-10-01 00:00:00

  • Tolfenamic acid inhibits ovarian cancer cell growth and decreases the expression of c-Met and survivin through suppressing specificity protein transcription factors.

    abstract:OBJECTIVE:The aberrant expression of hepatocyte growth factor and its receptor c-Met are associated with aggressive disease and poor prognosis in a variety of human malignancies including ovarian cancer (OC). Specificity protein (Sp) transcription factors have high relevance in the signaling cascade associated with c-M...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Basha R,Ingersoll SB,Sankpal UT,Ahmad S,Baker CH,Edwards JR,Holloway RW,Kaja S,Abdelrahim M

    更新日期:2011-07-01 00:00:00

  • HPV vaccine: A comparison of attitudes and behavioral perspectives between Latino and non-Latino women.

    abstract:OBJECTIVE:Recent scientific advances have lead to the development of a prophylactic, quadrivalent HPV vaccine conferring. We surveyed Latino and non-Latino women directly to examine what motivates them to vaccinate themselves, their daughters, and their sons. METHODS:A written survey was administered to 86 Latinas and...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Watts LA,Joseph N,Wallace M,Rauh-Hain JA,Muzikansky A,Growdon WB,del Carmen MG

    更新日期:2009-03-01 00:00:00

  • Radical hysterectomy for recurrent cervical cancer following radiation therapy.

    abstract::In patients with small central recurrences following radiation therapy for cervical cancer the surgeon may have to make a judgment as to when radical hysterectomy is preferable to exenteration. During the years 1968-1984 there were 21 radical hysterectomies performed at Memorial Sloan-Kettering Cancer Center for recur...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Rubin SC,Hoskins WJ,Lewis JL Jr

    更新日期:1987-07-01 00:00:00

  • Laparoscopic restaging of early stage invasive adnexal tumors: a 10-year experience.

    abstract:UNLABELLED:Surgical staging of apparent early stage adnexal carcinoma provides indispensable information. A significant number of patients are referred to tertiary centers with inadequate staging information. We report on our experience with late results of laparoscopic restaging procedure in uncompletely managed early...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Leblanc E,Querleu D,Narducci F,Occelli B,Papageorgiou T,Sonoda Y

    更新日期:2004-09-01 00:00:00