Stage III ovarian tumors of low malignant potential treated with cisplatin combination therapy (a Gynecologic Oncology Group study).

Abstract:

:By serendipity we have had the opportunity to evaluate cis-platin-based chemotherapy in ovarian tumors of low malignant potential (LMP). Optimal (less than 1 cm residual disease) FIGO stage III ovarian carcinomas were randomly assigned to treatment with cisplatin plus cyclophosphamide with or without doxorubicin on a prospective Gynecologic Oncology Group Study. On review by the Gynecologic Oncology Group Pathology Committee, 32 of these cases were determined to represent low malignant potential tumors. Mean age of patients with these lesions was 48 years (range, 25-75 years). After initial cytoreduction, 19 patients had residual disease less than 1 cm and 13 had no residual. Twenty (62.5%) received cisplatin plus cyclophosphamide and 12 cisplatin, cyclophosphamide, and doxorubicin chemotherapy; 75% of patients received six or more courses. Second-look surgery was done in 15 cases; only six were negative. However, with a median follow-up of 31.7 months (range, 1-75), only 1 patient has died; no cancer was found at autopsy. The remaining patients are alive without clinical evidence of disease at a median of 30 months. The need for adjunctive therapy in patients with advanced LMP tumors remains speculative.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Sutton GP,Bundy BN,Omura GA,Yordan EL,Beecham JB,Bonfiglio T

doi

10.1016/0090-8258(91)90314-u

subject

Has Abstract

pub_date

1991-06-01 00:00:00

pages

230-3

issue

3

eissn

0090-8258

issn

1095-6859

pii

0090-8258(91)90314-U

journal_volume

41

pub_type

临床试验,杂志文章,随机对照试验
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    更新日期:2003-08-01 00:00:00

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    更新日期:2001-06-01 00:00:00

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    更新日期:1997-07-01 00:00:00

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    更新日期:1993-03-01 00:00:00

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    pub_type: 临床试验,杂志文章,多中心研究

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    pub_type: 杂志文章,多中心研究

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    pub_type: 杂志文章,评审

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    更新日期:2009-08-01 00:00:00

  • Updates and emerging therapies for rare epithelial ovarian cancers: one size no longer fits all.

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    pub_type: 杂志文章,评审

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  • Endometrial cancer in Asian and American Indian/Alaskan Native women: tumor characteristics, treatment and outcome compared to non-Hispanic white women.

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    更新日期:2009-06-01 00:00:00

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    更新日期:1995-08-01 00:00:00

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