Lipid emulsion pretreatment has different effects on mepivacaine and bupivacaine cardiac toxicity in an isolated rat heart model.

abstract：:We have examined the extradural space using a flexible extraduroscope in 74 patients undergoing extradural anaesthesia at the L2-3 interspace. Extraduroscopy showed that the extradural space becomes widely patent and the fatty tissue in the extradural space diminishes with increasing age. We postulate that these age-r...

journal_title：British journal of anaesthesia

authors： Igarashi T,Hirabayashi Y,Shimizu R,Saitoh K,Fukuda H,Mitsuhata H

更新日期：1997-02-01 00:00:00

abstract：:Midazolam is often used for paediatric premedication. We have compared two methods of administering midazolam intranasally in 44 surgical day-case children allocated randomly to receive midazolam 0.2 mg kg-1 as drops or midazolam 0.1 mg kg-1 from an intranasal spray device. Behaviour was recorded on a four-point scale...

journal_title：British journal of anaesthesia

authors： Griffith N,Howell S,Mason DG

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:Pulse pressure variation (PPV) and stroke volume variation (SVV) are robust indicators of fluid responsiveness in mechanically ventilated supine patients. The aim of the study was to evaluate the ability of PPV and SVV to predict fluid responsiveness in mechanically ventilated patients in the prone position ...

journal_title：British journal of anaesthesia

authors： Biais M,Bernard O,Ha JC,Degryse C,Sztark F

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:A significantly increased risk of acute kidney injury (AKI) with the prophylactic use of aprotinin has been reported in adults undergoing cardiac surgery, but not in children. Blood product transfusions have also been shown to carry an independent risk of AKI. The present study assessed associations between ...

journal_title：British journal of anaesthesia

authors： Bojan M,Vicca S,Boulat C,Gioanni S,Pouard P

更新日期：2012-05-01 00:00:00

abstract：:Intraoperative awareness, with or without recall, continues to be a topic of clinical significance and neurobiological interest. In this article, we review evidence pertaining to the incidence, sequelae, and prevention of intraoperative awareness. We also assess which aspects of the complication are well understood (i...

journal_title：British journal of anaesthesia

authors： Mashour GA,Avidan MS

更新日期：2015-07-01 00:00:00

abstract：:We studied the interaction between paracetamol (acetaminophen U.S.P.) and enflurane. Sixteen rats were assigned to four groups (n = 4) to receive: paracetamol 7.5 mg/100 g body weight; paracetamol plus 1% enflurane; 1% enflurane alone, or no treatment (controls). Animals were killed 6 h later. A second series of 16 we...

journal_title：British journal of anaesthesia

authors： Hanna AN,McDonald JS,Miller CH Jr,Couri D

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:Ketamine-induced neuroapoptosis has been attributed to diverse stress-related mechanisms. Glycogen synthase kinase-3β (GSK-3β) is a multifunctional kinase that is active in neuronal development and linked to neurodegenerative disorders. We hypothesized that ketamine would enhance GSK-3β-induced neuroapopotos...

journal_title：British journal of anaesthesia

authors： Liu JR,Baek C,Han XH,Shoureshi P,Soriano SG

更新日期：2013-06-01 00:00:00

abstract：:Volume loading with crystalloid solution results in more pronounced haemodilution in patients who develop arterial hypotension during induction of extradural anaesthesia than in those who remain normotensive. The aim of this study was to describe the time course of this increase in haemodilution. Heart rate, systolic ...

journal_title：British journal of anaesthesia

authors： Drobin D,Hahn RG

更新日期：1996-08-01 00:00:00

abstract：:Acute perioperative changes in arterial pressure occur frequently, particularly in patients with cardiovascular disease or those receiving vasoactive medications, or in relation to certain cardiovascular surgical procedures. Both hypo- and hypertension are common in patients undergoing carotid surgery because of uniqu...

journal_title：British journal of anaesthesia

authors： Stoneham MD,Thompson JP

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Studies of the accuracy of partial rebreathing measurements of pulmonary blood flow (PBF) in patients with abnormal lungs have not fully explained the sources of error. METHODS:We used computer models of emphysema and pulmonary embolism incorporating both ventilation-perfusion (V/Q) and ventilation-volume (...

journal_title：British journal of anaesthesia

authors： Yem JS,Turner MJ,Baker AB

更新日期：2006-11-01 00:00:00

abstract：:Plasma concentrations of pancuronium were measured using a fluorimetric method in six patients with normal renal function and seven patients in chronic renal failure. A tow-compartment open model was used in the pharmacokinetic analysis of the data. With this model, the clearance of pancuronium was found to be reduce...

journal_title：British journal of anaesthesia

authors： McLeod K,Watson MJ,Rawlins MD

更新日期：1976-04-01 00:00:00

abstract：BACKGROUND:Some anaesthetic agents exhibit an age-dependent analgesic effect, for example nitrous oxide, which is ineffective in newborn rats. We investigated whether a similar time dependency existed for the responses to the volatile anaesthetic isoflurane. METHODS:The analgesic and hypnotic properties of isoflurane ...

journal_title：British journal of anaesthesia

authors： Sanders RD,Patel N,Hossain M,Ma D,Maze M

更新日期：2005-09-01 00:00:00

abstract：:We have studied 16 healthy volunteers whose lungs were preoxygenated six times each in order to assess the amount of room air entrained during tidal volume preoxygenation if a good seal is not maintained between the face mask and the face. With a fresh gas flow of 10 litre min-1, we found that using gravity alone to h...

journal_title：British journal of anaesthesia

authors： McGowan P,Skinner A

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Aortocaval compression (ACC) can result in haemodynamic disturbances and uteroplacental hypoperfusion in parturients. Its detection is difficult because in most patients, sympathetic compensation results in no signs or symptoms. However, profound hypotension may develop after sympathectomy during regional an...

journal_title：British journal of anaesthesia

authors： Lee SW,Khaw KS,Ngan Kee WD,Leung TY,Critchley LA

更新日期：2012-12-01 00:00:00

abstract：:Profound postoperative respiratory depression after larger doses of fentanyl was partially reversed by 4-aminopyridine. This reversal was independent of FIO2' suggesting that the response was not dependent upon peripheral chemoreceptor-mediated drive. Similar reversal of fentanyl-induced depression by 4-aminopyridine ...

journal_title：British journal of anaesthesia

authors： Sia RL,Zandstra DF

更新日期：1981-04-01 00:00:00

abstract：:Temazepam elixir 30 mg by mouth was compared with i.v. Diazemuls titrated to a maximum dose of 20 mg in a double-blind study of 50 patients undergoing elective minor oral surgery. The treatments produced a similar reduction in anxiety score and similar degrees of patient relaxation and co-operation. The diazepam group...

journal_title：British journal of anaesthesia

authors： Hosie HE,Brook IM,Nimmo WS

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Intraperitoneal insufflation of carbon dioxide (CO2) may promote collapse of dependent lung regions. The present study was undertaken to study the effects of CO2-pneumoperitoneum (CO2-PP) on atelectasis formation, arterial oxygenation, and arterial to end-tidal PCO2-gradient (Pa-E'(CO2)). METHODS:Fifteen an...

journal_title：British journal of anaesthesia

authors： Strang CM,Hachenberg T,Fredén F,Hedenstierna G

更新日期：2009-08-01 00:00:00

abstract：:Topical capsaicin formulations are used for pain management. Safety and modest efficacy of low-concentration capsaicin formulations, which require repeated daily self-administration, are supported by meta-analyses of numerous studies. A high-concentration capsaicin 8% patch (Qutenza™) was recently approved in the EU a...

journal_title：British journal of anaesthesia

authors： Anand P,Bley K

更新日期：2011-10-01 00:00:00

abstract：:Logistical and ethical reasons make conducting clinical research in paediatric practice difficult, and therefore safe and efficacious advances are dependent on good preclinical research. For example, notable advances have been made in preclinical studies of pain processing that correlate well with patient data. Other ...

journal_title：British journal of anaesthesia

authors： Sanders RD,Ma D,Brooks P,Maze M

更新日期：2008-11-01 00:00:00

abstract：:We have studied in eight rabbits the cardiovascular effects of midazolam, propofol and alfentanil with graded hypoxia. Central blood volume was reduced progressively by gradual inflation of a thoracic vena cava cuff so that cardiac index (CI) decreased at a constant rate. Under control conditions the haemodynamic resp...

journal_title：British journal of anaesthesia

authors： Blake DW,Van Leeuwen AF,Petring OU,Ludbrook J,Ventura S

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Double-lumen tubes (DLTs) are frequently used to establish one-lung ventilation (OLV). Their correct placement is crucial. We hypothesized that electrical impedance tomography (EIT) reliably displays distribution of ventilation between left and right lung and may thus be used to verify correct DLT placement ...

journal_title：British journal of anaesthesia

authors： Steinmann D,Stahl CA,Minner J,Schumann S,Loop T,Kirschbaum A,Priebe HJ,Guttmann J

更新日期：2008-09-01 00:00:00

abstract：:In this study, we have compared two different doses of clonidine (bolus of 25 micrograms and infusion of 19 micrograms h-1; bolus of 50 micrograms and infusion of 37 micrograms h-1, both added to 0.03% bupivacaine) with a control group of 0.03% bupivacaine alone. The study was performed in a randomized, double-blind m...

journal_title：British journal of anaesthesia

authors： Tremlett MR,Kelly PJ,Parkins J,Hughes D,Redfern N

更新日期：1999-08-01 00:00:00

abstract：:Human error poses significant risk for hospitalized patients causing an estimated 100,000 to 400,000 deaths in the USA annually. Medication errors contribute, with error occurring in 5.3% of medication administrations during surgery. In this study 70.3% of medication errors were deemed preventable. Given the paucity o...

journal_title：British journal of anaesthesia

authors： Wahr JA,Abernathy JH 3rd,Lazarra EH,Keebler JR,Wall MH,Lynch I,Wolfe R,Cooper RL

更新日期：2017-01-01 00:00:00

abstract：:Many indices are used to quantify pulmonary oxygen transfer. Indices that use only measurements from arterial blood and inspired gas assume a constant C(a-v)O2. Though variations in C(a-v)O2 are recognized, indices such as PaO2/FIO2 remain popular and are often considered the best measure of pulmonary oxygen transfer ...

journal_title：British journal of anaesthesia

authors： Nirmalan M,Willard T,Columb MO,Nightingale P

更新日期：2001-04-01 00:00:00

abstract：:The haemodynamic effects of diltiazem were studied in six dogs during fentanyl-nitrous oxide (in oxygen) anaesthesia. A bolus of diltiazem 300 micrograms kg-1 was given, followed by infusions at 30, 60 and 90 micrograms kg-1 min-1 which produced plasma diltiazem concentrations of 392 +/- 30, 908 +/- 54 and 1483 +/- 13...

journal_title：British journal of anaesthesia

authors： Griffin RM,Dimich I,Jurado R,Kaplan JA

更新日期：1988-05-01 00:00:00

abstract：:We have compared, in a randomized, double-blind study, the pharmacokinetics of ropivacaine and bupivacaine during labour. Total and free plasma concentrations of ropivacaine and bupivacaine were measured after the first of two extradural doses. The main dose was 20 mg (test dose) and 30 mg, with a top-up dose of 25 mg...

journal_title：British journal of anaesthesia

authors： McCrae AF,Westerling P,McClure JH

更新日期：1997-11-01 00:00:00

abstract：:A specific technique for detection of pulmonary aspiration during the perioperative period is lacking. In this study, we developed a scintigraphic method for its diagnosis. Technetium 99m sulphur colloid was given orally 2 h before an i.v. infusion of propofol in patients undergoing elective colonoscopy. During the pr...

journal_title：British journal of anaesthesia

authors： Rezaiguia-Delclaux S,Streich B,Bouleau D,Delchier JC,Dhonneur G,Meignan M,Duvaldestin P

更新日期：2001-08-01 00:00:00

abstract：:A computer program written mainly in a high level language (ALGOL), but with the sampling routine and certain calculations written in assembly language (SIR), has been developed to assess neuromuscular blockade in anaesthetized man by means of an Elliott 903 digital computer. The program allows the on-line real-time a...

journal_title：British journal of anaesthesia

authors： Perry IR,Worsley R,Sugai N,Payne JP

更新日期：1975-10-01 00:00:00

abstract：:We have examined dimethylthiourea, a potent scavenger of free radicals, for its anaesthetic properties in mice and rats. In mice, dimethylthiourea abolished the righting reflex at intraperitoneal doses greater than 1.5 mg g-1 bodyweight; in rats, it decreased the MAC value for isoflurane in a dose-dependent fashion. D...

journal_title：British journal of anaesthesia

authors： Koblin DD,Laster MJ,Liu J

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:The aim of this study is to test the hypothesis that a standard 30-min break in a routine 7.5 h period of work makes a difference in cognitive function. METHODS:In a double-blinded, cross-over trial 30 residents in anaesthesia were randomized to receive or not to receive a 30-min break between the assessmen...

journal_title：British journal of anaesthesia

authors： Coburn M,Henzler D,Baumert JH,Fimm B,Drüke B,Rossaint R

更新日期：2006-09-01 00:00:00