Abstract:
OBJECTIVES:Sensory over-responsivity (SOR), defined as a negative response to or avoidance of sensory stimuli, is both highly prevalent and extremely impairing in youth with autism spectrum disorders (ASD), yet little is known about the neurological bases of SOR. This study aimed to examine the functional neural correlates of SOR by comparing brain responses to sensory stimuli in youth with and without ASD. METHOD:A total of 25 high-functioning youth with ASD and 25 age- and IQ-equivalent typically developing (TD) youth were presented with mildly aversive auditory and visual stimuli during a functional magnetic resonance imaging (fMRI) scan. Parents provided ratings of children's SOR and anxiety symptom severity. RESULTS:Compared to TD participants, ASD participants displayed greater activation in primary sensory cortical areas as well as amygdala, hippocampus, and orbital-frontal cortex. In both groups, the level of activity in these areas was positively correlated with level of SOR severity as rated by parents, over and above behavioral ratings of anxiety. CONCLUSIONS:This study demonstrates that youth with ASD show neural hyper-responsivity to sensory stimuli, and that behavioral symptoms of SOR may be related to both heightened responsivity in primary sensory regions as well as areas related to emotion processing and regulation.
journal_name
J Am Acad Child Adolesc Psychiatryauthors
Green SA,Rudie JD,Colich NL,Wood JJ,Shirinyan D,Hernandez L,Tottenham N,Dapretto M,Bookheimer SYdoi
10.1016/j.jaac.2013.08.004subject
Has Abstractpub_date
2013-11-01 00:00:00pages
1158-72issue
11eissn
0890-8567issn
1527-5418pii
S0890-8567(13)00540-6journal_volume
52pub_type
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
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更新日期:2014-10-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 杂志文章,评审
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更新日期:2002-11-01 00:00:00
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journal_title:Journal of the American Academy of Child and Adolescent Psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-01-01 00:00:00
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更新日期:2004-02-01 00:00:00