Overreactive brain responses to sensory stimuli in youth with autism spectrum disorders.

Abstract:

OBJECTIVES:Sensory over-responsivity (SOR), defined as a negative response to or avoidance of sensory stimuli, is both highly prevalent and extremely impairing in youth with autism spectrum disorders (ASD), yet little is known about the neurological bases of SOR. This study aimed to examine the functional neural correlates of SOR by comparing brain responses to sensory stimuli in youth with and without ASD. METHOD:A total of 25 high-functioning youth with ASD and 25 age- and IQ-equivalent typically developing (TD) youth were presented with mildly aversive auditory and visual stimuli during a functional magnetic resonance imaging (fMRI) scan. Parents provided ratings of children's SOR and anxiety symptom severity. RESULTS:Compared to TD participants, ASD participants displayed greater activation in primary sensory cortical areas as well as amygdala, hippocampus, and orbital-frontal cortex. In both groups, the level of activity in these areas was positively correlated with level of SOR severity as rated by parents, over and above behavioral ratings of anxiety. CONCLUSIONS:This study demonstrates that youth with ASD show neural hyper-responsivity to sensory stimuli, and that behavioral symptoms of SOR may be related to both heightened responsivity in primary sensory regions as well as areas related to emotion processing and regulation.

authors

Green SA,Rudie JD,Colich NL,Wood JJ,Shirinyan D,Hernandez L,Tottenham N,Dapretto M,Bookheimer SY

doi

10.1016/j.jaac.2013.08.004

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

1158-72

issue

11

eissn

0890-8567

issn

1527-5418

pii

S0890-8567(13)00540-6

journal_volume

52

pub_type

杂志文章
  • Behavioral and cognitive characteristics of females and males with autism in the Simons Simplex Collection.

    abstract:OBJECTIVE:To examine differences in behavioral symptoms and cognitive functioning between males and females with autism spectrum disorder (ASD). METHOD:We analyzed data from 2,418 probands with autism (304 females and 2,114 males) included in the Simons Simplex Collection. Sex differences were evaluated across measure...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2013.12.004

    authors: Frazier TW,Georgiades S,Bishop SL,Hardan AY

    更新日期:2014-03-01 00:00:00

  • Identity, Conformity, and Nonconformity: A Closer Look.

    abstract::As clinicians, we have been vigilant to screen for underlying psychopathology in children and adolescents who meet criteria for gender dysphoria (GD) based on the risk these individuals have for developing externalizing and/or internalizing disorders, likely driven by a stigmatizing society. However, we have not paid ...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 评论,社论

    doi:10.1016/j.jaac.2018.05.001

    authors: Daniolos PT

    更新日期:2018-07-01 00:00:00

  • Breastfeeding and Childhood IQ: The Mediating Role of Gray Matter Volume.

    abstract:OBJECTIVE:A substantial body of literature has established the positive effect of breastfeeding on child developmental outcomes. There is increasing consensus that breastfed children have higher IQs after accounting for key variables, including maternal education, IQ, and socioeconomic status. Cross-sectional investiga...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2016.02.009

    authors: Luby JL,Belden AC,Whalen D,Harms MP,Barch DM

    更新日期:2016-05-01 00:00:00

  • Special issues in child custody evaluations.

    abstract::The child and adolescent psychiatrist who performs child custody evaluations assumes an extraordinary responsibility. Operating at the interface of psychiatry and the law, this forensic psychiatrist is often confronted by special factors that can make a normally complicated process even more intricate. This paper exam...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199011000-00024

    authors: Herman SP

    更新日期:1990-11-01 00:00:00

  • Selective serotonin reuptake inhibitor-induced sexual dysfunction in adolescents: a review.

    abstract:OBJECTIVE:To review the existing literature on selective serotonin reuptake inhibitor (SSRI)-induced sexual dysfunction in adolescents. METHOD:A literature review of SSRI-induced adverse effects in adolescents focusing on sexual dysfunction was done. Nonsexual SSRI-induced adverse effects were compared in adult and pe...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,评审

    doi:10.1097/01.chi.0000131135.70992.58

    authors: Scharko AM

    更新日期:2004-09-01 00:00:00

  • Predictors of treatment efficacy in a clinical trial of three psychosocial treatments for adolescent depression.

    abstract:OBJECTIVE:To assess the predictors of treatment outcome across treatments, as well as those associated with differential treatment response. METHOD:One hundred seven adolescent outpatients, aged 13 to 18 years, with DSM-III-R major depression were randomly assigned to one of three manual-based, brief (12 to 16 session...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004583-199809000-00010

    authors: Brent DA,Kolko DJ,Birmaher B,Baugher M,Bridge J,Roth C,Holder D

    更新日期:1998-09-01 00:00:00

  • A comparison of American and English hospital discharge rates for pediatric bipolar disorder, 2000 to 2010.

    abstract:OBJECTIVE:Controversy exists over the diagnosis and prevalence of pediatric bipolar disorder (PBD). Although several small surveys suggest that the rate of the PBD diagnosis in clinical settings is higher in the United States than in other countries, no comprehensive cross-national comparisons of clinical practice have...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2014.02.008

    authors: James A,Hoang U,Seagroatt V,Clacey J,Goldacre M,Leibenluft E

    更新日期:2014-06-01 00:00:00

  • Commentary: Gene-environment interplay in the context of genetics, epigenetics, and gene expression.

    abstract:OBJECTIVE:To comment on the article in this issue of the Journal by Professor Michael Rutter, "Environmentally Mediated Risks for Psychopathology: Research Strategies and Findings," in the context of current research findings on gene-environment interaction, epigenetics, and gene expression. METHOD:Animal and human st...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 评论,杂志文章

    doi:10.1097/01.chi.0000145804.30112.6b

    authors: Kramer DA

    更新日期:2005-01-01 00:00:00

  • 18-month predictors of later outcomes in younger siblings of children with autism spectrum disorder: a baby siblings research consortium study.

    abstract:OBJECTIVE:Younger siblings of children with autism spectrum disorder (ASD) are at high risk (HR) for developing ASD as well as features of the broader autism phenotype. Although this complicates early diagnostic considerations in this cohort, it also provides an opportunity to examine patterns of behavior associated sp...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.jaac.2014.09.015

    authors: Chawarska K,Shic F,Macari S,Campbell DJ,Brian J,Landa R,Hutman T,Nelson CA,Ozonoff S,Tager-Flusberg H,Young GS,Zwaigenbaum L,Cohen IL,Charman T,Messinger DS,Klin A,Johnson S,Bryson S

    更新日期:2014-12-01 00:00:00

  • Prevalence of mental disorder in military children and adolescents: findings from a two-stage community survey.

    abstract:OBJECTIVE:Because previous reports have suggested that children of military families are at greater risk for psychopathology, this study examines the levels of psychopathology in an epidemiological community sample of military children all living on a military post. METHOD:Standardized psychopathology rating scales an...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004583-199511000-00019

    authors: Jensen PS,Watanabe HK,Richters JE,Cortes R,Roper M,Liu S

    更新日期:1995-11-01 00:00:00

  • Cognitive Effects of Stimulant, Guanfacine, and Combined Treatment in Child and Adolescent Attention-Deficit/Hyperactivity Disorder.

    abstract:OBJECTIVE:Psychostimulants are partially effective in reducing cognitive dysfunction associated with attention-deficit/hyperactivity disorder (ADHD). Cognitive effects of guanfacine, an alternative treatment, are poorly understood. Given its distinct action on α2A receptors, guanfacine may have different or complementa...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jaac.2016.05.016

    authors: Bilder RM,Loo SK,McGough JJ,Whelan F,Hellemann G,Sugar C,Del'Homme M,Sturm A,Cowen J,Hanada G,McCracken JT

    更新日期:2016-08-01 00:00:00

  • Evaluation of a preventive intervention for maltreated infants and toddlers in foster care.

    abstract:OBJECTIVE:To determine the effectiveness of an intervention designed to improve outcomes for infants and toddlers in foster care. METHOD:Records were reviewed for all children who were adjudicated as in need of care in a specific parish in Louisiana between 1991 and 1998. This period included 4 years before and 4 year...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004583-200102000-00016

    authors: Zeanah CH,Larrieu JA,Heller SS,Valliere J,Hinshaw-Fuselier S,Aoki Y,Drilling M

    更新日期:2001-02-01 00:00:00

  • Anorexia nervosa and bulimia nervosa in adolescence: effects of age and menstrual status on psychological variables.

    abstract:OBJECTIVE:To compare, in adolescents and adults with anorexia nervosa and bulimia nervosa, eating disorder symptomatology and comorbid affective and anxiety states. METHOD:Two hundred fifty consecutive, female inpatients on an eating disorders unit were studied. They were given the Beck Depression Inventory; the Depre...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199503000-00024

    authors: Heebink DM,Sunday SR,Halmi KA

    更新日期:1995-03-01 00:00:00

  • Psychiatric comorbidity and the 16-month trajectory of substance-abusing and substance-dependent juvenile offenders.

    abstract:OBJECTIVES:To examine the concurrent correlates of internalizing and externalizing disorders among substance-abusing and substance-dependent juvenile offenders and to determine the association between psychiatric comorbidity and psychosocial functioning of the youths 16 months later. METHOD:Participants were 118 juven...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199909000-00015

    authors: Randall J,Henggeler SW,Pickrel SG,Brondino MJ

    更新日期:1999-09-01 00:00:00

  • Preventive intervention for maltreated preschool children: impact on children's behavior, neuroendocrine activity, and foster parent functioning.

    abstract:OBJECTIVE:This article describes the results of a pilot study that evaluated the effectiveness of the Early Intervention Foster Care (EIFC) program in the period immediately following a child's placement in a new foster home. METHOD:Data were collected from an EIFC group, a regular foster care group, and a community c...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-200011000-00009

    authors: Fisher PA,Gunnar MR,Chamberlain P,Reid JB

    更新日期:2000-11-01 00:00:00

  • The Screen for Child Anxiety Related Emotional Disorders (SCARED): scale construction and psychometric characteristics.

    abstract:OBJECTIVE:To develop a reliable and valid child and parent self-report instrument to screen children with anxiety disorders. METHOD:An 85-item questionnaire was administered to 341 outpatient children and adolescents and 300 parents. Utilizing item analyses and factor analyses, the original scale was reduced to 38 ite...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199704000-00018

    authors: Birmaher B,Khetarpal S,Brent D,Cully M,Balach L,Kaufman J,Neer SM

    更新日期:1997-04-01 00:00:00

  • Children's Interview for Psychiatric Syndromes (ChIPS).

    abstract:OBJECTIVE:To describe the development and summarize the psychometric properties of the Children's Interview for Psychiatric Syndromes (ChIPS). METHOD:ChIPS is a highly structured interview designed for use by trained lay interviewers in children aged 6-18 years. It screens for 20 Axis I disorders as well as psychosoci...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-200001000-00019

    authors: Weller EB,Weller RA,Fristad MA,Rooney MT,Schecter J

    更新日期:2000-01-01 00:00:00

  • Psychosocial factors associated with urban adolescent female suicide attempts.

    abstract::This study identified psychosocial factors that differentiated 19 adolescent female suicide attempters from 21 demographically similar nonattempters in a low income, urban area. Adolescents and their parents independently completed questionnaires and participated in structured and semistructured interviews. Attempters...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199003000-00020

    authors: King CA,Raskin A,Gdowski CL,Butkus M,Opipari L

    更新日期:1990-03-01 00:00:00

  • Affect attunement, attachment, temperament, and zygosity: a twin study.

    abstract::A twin study examines the relationship of affect attunement to four factors of development: zygosity, temperament, attachment, and twin preference. Affect attunement occurs when an infant expresses affect and a mother responds cross-modally, matching duration, intensity, and rhythm. A sample of 16, same sex, healthy t...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-198903000-00017

    authors: Szajnberg NM,Skrinjaric J,Moore A

    更新日期:1989-03-01 00:00:00

  • Bupropion versus methylphenidate in the treatment of attention-deficit hyperactivity disorder.

    abstract:OBJECTIVE:In the treatment of attention-deficit hyperactivity disorder (ADHD), the efficacy of the tricyclic antidepressants and monoamine oxidase inhibitor antidepressants has been compared with that of both placebo and the stimulants (methylphenidate and/or dextroamphetamine). However, the effectiveness of bupropion ...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004583-199505000-00017

    authors: Barrickman LL,Perry PJ,Allen AJ,Kuperman S,Arndt SV,Herrmann KJ,Schumacher E

    更新日期:1995-05-01 00:00:00

  • Cognitive inflexibility and frontal-cortical activation in pediatric obsessive-compulsive disorder.

    abstract:OBJECTIVE:Deficits in cognitive flexibility and response inhibition have been linked to perturbations in cortico-striatal-thalamic circuitry in adult obsessive-compulsive disorder (OCD). Although similar cognitive deficits have been identified in pediatric OCD, few neuroimaging studies have been conducted to examine it...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2010.05.006

    authors: Britton JC,Rauch SL,Rosso IM,Killgore WD,Price LM,Ragan J,Chosak A,Hezel DM,Pine DS,Leibenluft E,Pauls DL,Jenike MA,Stewart SE

    更新日期:2010-09-01 00:00:00

  • Depressive disorders in maltreated children.

    abstract::This study examined the prevalence of depressive disorders in a sample of 56 7- to 12-year-old maltreated children. Overall, 18% of the sample met the diagnostic criteria for major depression, and 25% met the criteria for dysthymia, with the majority of the children who met the criteria for major depression also meeti...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199103000-00014

    authors: Kaufman J

    更新日期:1991-03-01 00:00:00

  • Cognitive-behavioral therapy for adolescent depression: a meta-analytic investigation of changes in effect-size estimates.

    abstract:OBJECTIVE:To explicate differences between early and recent meta-analytic estimates of the effects of cognitive-behavioral therapy (CBT) for adolescent depression. METHOD:Meta-analytic procedures were used to investigate whether methodological characteristics moderated mean effect sizes among 11 randomized, controlled...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,meta分析

    doi:10.1097/chi.0b013e3180592aaa

    authors: Klein JB,Jacobs RH,Reinecke MA

    更新日期:2007-11-01 00:00:00

  • Early generalized overgrowth in autism spectrum disorder: prevalence rates, gender effects, and clinical outcomes.

    abstract:OBJECTIVE:Although early head and body overgrowth have been well documented in autism spectrum disorder (ASD), their prevalence and significance remain unclear. It is also unclear whether overgrowth affects males and females differentially, and whether it is associated with clinical outcomes later in life. METHOD:To e...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2014.07.008

    authors: Campbell DJ,Chang J,Chawarska K

    更新日期:2014-10-01 00:00:00

  • Implications of extending the ADHD age-of-onset criterion to age 12: results from a prospectively studied birth cohort.

    abstract:OBJECTIVE:To evaluate whether including children with onset of symptoms between ages 7 and 12 years in the ADHD diagnostic category would: (a) increase the prevalence of the disorder at age 12, and (b) change the clinical and cognitive features, impairment profile, and risk factors for ADHD compared with findings in th...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:

    authors: Polanczyk G,Caspi A,Houts R,Kollins SH,Rohde LA,Moffitt TE

    更新日期:2010-03-01 00:00:00

  • Systematic Review and Meta-analysis: The Prevalence of Mental Illness in Child and Adolescent Refugees and Asylum Seekers.

    abstract:OBJECTIVE:Over half of the world's refugee population are under the age of 18 years. This systematic review aims to summarize the current body of evidence for the prevalence of mental illness in child and adolescent refugee populations. METHOD:Eight electronic databases, gray literature, and Google Scholar were search...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaac.2019.11.011

    authors: Blackmore R,Gray KM,Boyle JA,Fazel M,Ranasinha S,Fitzgerald G,Misso M,Gibson-Helm M

    更新日期:2020-06-01 00:00:00

  • Oppositional defiant disorder and conduct disorder: a review of the past 10 years, part II.

    abstract:OBJECTIVE:To review empirical findings on oppositional defiant disorder (ODD) and conduct disorder (CD). METHOD:Selected summaries of the literature over the past decade are presented. RESULTS:Research on ODD and CD during the past decade has addressed the complexity involved in identifying the primary risk factors a...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,评审

    doi:10.1097/00004583-200211000-00009

    authors: Burke JD,Loeber R,Birmaher B

    更新日期:2002-11-01 00:00:00

  • Effects of methylphenidate on reward strength in boys with attention-deficit hyperactivity disorder.

    abstract:OBJECTIVE:To test the hypothesis that methylphenidate reduces thresholds for reward in children with attention-deficit hyperactivity disorder (ADHD). METHOD:A double-blind crossover design was used in which 16 ADHD boys, aged 8 to 13 years, received methylphenidate on one testing occasion and placebo on another. On ea...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004583-199507000-00013

    authors: Wilkison PC,Kircher JC,McMahon WM,Sloane HN

    更新日期:1995-07-01 00:00:00

  • Cognitive risk factors and suicide attempts among formerly hospitalized adolescents: a prospective naturalistic study.

    abstract:OBJECTIVE:To examine the relationship between cognitive variables and time until suicide attempts among 180 adolescents who were monitored for as much as 6.9 years after discharge from an inpatient psychiatry unit. METHOD:In a prospective naturalistic study, adolescents were assessed at the time of their psychiatric h...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-200101000-00021

    authors: Goldston DB,Daniel SS,Reboussin BA,Reboussin DM,Frazier PH,Harris AE

    更新日期:2001-01-01 00:00:00

  • Quality of life in children with psychiatric disorders: self-, parent, and clinician report.

    abstract:OBJECTIVE:To study the relationship between child psychiatric disorders and quality of life (QoL). METHOD:In a sample of 310 children (ages 6-18 years) referred for psychiatric problems, children, parents, and clinicians reported on psychopathology and subjective and objective QoL indicators. RESULTS:Six diagnostic c...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-200402000-00019

    authors: Bastiaansen D,Koot HM,Ferdinand RF,Verhulst FC

    更新日期:2004-02-01 00:00:00