Apoptosis induced by tumor necrosis factor in cells chronically infected with feline immunodeficiency virus.

Abstract:

:Tumor necrosis factor alpha (TNF-alpha) induced morphologic changes such as chromatin condensation and cell shrinkage in a feline fibroblastic cell line (CRFK) chronically infected with feline immunodeficiency virus (FIV) but not in uninfected CRFK cells. DNA extracted from TNF-alpha-treated CRFK cells infected with FIV showed a ladder of nucleosomal DNA, indicating that this cytocidal effect by TNF-alpha was due to programmed cell death, or apoptosis. These findings may have implications for understanding the pathogenesis of FIV infection and for the design of specific therapeutic strategies for AIDS in humans as well as cats.

journal_name

J Virol

journal_title

Journal of virology

authors

Ohno K,Nakano T,Matsumoto Y,Watari T,Goitsuka R,Nakayama H,Tsujimoto H,Hasegawa A

doi

10.1128/JVI.67.5.2429-2433.1993

subject

Has Abstract

pub_date

1993-05-01 00:00:00

pages

2429-33

issue

5

eissn

0022-538X

issn

1098-5514

journal_volume

67

pub_type

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