Abstract:
:Water/n-octanol partition coefficients (log P) for 33 1,2-dithiole-3-thiones and for 18 1,2-dithiol-3-ones were determined by RP-HPLC measurement of the concentration of the solute in aqueous solution after equilibrium. Depending on the nature of the substituents (alkyl or aryl) and their position(s) (4,5, or both) on the dithiole nucleus, some peculiar behaviors were revealed. Therefore, different fragmental constants containing the 1,2-dithiole-3-thione nucleus were inferred in order to calculate in a complementary work, a priori, the log P values of new dithiolethiones and dithiolones.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Bona M,Boudeville P,Zekri O,Christen MO,Burgot JLdoi
10.1002/jps.2600840914subject
Has Abstractpub_date
1995-09-01 00:00:00pages
1107-12issue
9eissn
0022-3549issn
1520-6017pii
S0022-3549(15)49894-6journal_volume
84pub_type
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