Predictive factors for recurrence and survival in hepatocellular carcinoma in South Korea.

abstract：BACKGROUND:We conducted a phase II study of topotecan (Tp) with cisplatin (CDDP) in previously untreated Japanese patients with extensive-disease small cell lung cancer (ED-SCLC). PATIENTS AND METHODS:In stage 1, a total of 30 patients were allocated to Tp 0.65 mg/m(2) with CDDP 60 mg/m(2) day 1 or Tp 1.00 mg/m(2) wit...

journal_title：Anticancer research

authors： Hosomi Y,Shibuya M,Niho S,Ichinose Y,Kiura K,Sakai H,Takeda K,Kudo S,Eguchi K,Matsui K,Masuda N,Ando M,Watanabe K

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND/AIM:We performed a systematic review and meta-analysis to investigate the safety of maintenance with olaparib after platinum-based chemotherapy in cancer patients. MATERIALS AND METHODS:Eligible studies included randomized controlled trials (RCTs) regarding the clinical role of olaparib maintenance therapy ...

journal_title：Anticancer research

authors： Ricci AD,Rizzo A,Novelli M,Tavolari S,Palloni A,Tober N,Abbati F,Mollica V,DE Lorenzo S,Turchetti D,DI Marco M,Brandi G

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:5-Fluoro-2'-deoxyuridine (5-FdU), a drug against gastric cancer, was covalently linked via its nucleobase with the amino-bisphosphonate alendronate (Ale), resulting in a new antimetabolite-bisphosphonate conjugate (5-FdU-Ale), designed for bone-targeting. MATERIALS AND METHODS:The cytostatic effect of 5-FdU...

journal_title：Anticancer research

authors： Weinreich J,Schott TC,Königsrainer I,Küper M,Königsrainer A,Schott H

更新日期：2012-10-01 00:00:00

abstract：:To overcome 5-Fluorouracil (5FU) infusion-related problems, oral 5FU precursors and inhibitors of 5FU degradation have been developed. Capecitabine is one of these new oral fluoropyrimidines. Capecitabine treatment of advanced colorectal carcinoma, when compared to 5FU, results in superior response rates (26.6% versus...

journal_title：Anticancer research

authors： Pasetto LM,Monfardini S

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the fifth most common cancer in Africa, with significant differences in incidence, biology and clinical behavior from other populations. MATERIALS AND METHODS:We studied prevalence and clinicopathological features of microsatellite instability (MSI) and young onset CRC in 83 archi...

journal_title：Anticancer research

authors： Irabor DO,Oluwasola OA,Ogunbiyi OJ,Ogun OG,Okolo CA,Melas M,Gruber SB,Shi C,Raskin L

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Lung resistance-related protein (LRP) was first detected in a non-P-glycoprotein-mediated multidrug-resistant lung cancer cell line and has been shown to be the major human vault protein. The aim of this study was to evaluate the expression of LRP in germ cell testicular tumors (GCT) and to determine the cor...

journal_title：Anticancer research

authors： Mándoky L,Géczi L,Doleschall Z,Bodrogi I,Csuka O,Kásler M,Bak M

更新日期：2004-03-01 00:00:00

abstract：:Hexamethylmelamine (HMM) has previously been shown to be active against ovarian, breast and small cell lung cancer. However HMM dose not have aromatase-inhibitory activity. A newly developed HMM derivative, 2-N,N-dimethylamino-4, 6-bis (1-H-imidazol-1-yl)-1,3,5-triazine (SAE9), was found to have direct antitumor activ...

journal_title：Anticancer research

authors： Tanino H,Kubota T,Yamada Y,Koh JI,Takeuchi T,Kase S,Furukawa T,Takahashi M,Fukuda S,Ogose N

更新日期：1993-05-01 00:00:00

abstract：:Our investigation comprises 778 cases of resection for early gastric cancer (27.4% of all stomach resections). The rate of lymph node metastasis was 1.2% in m (mucosal cancer) group, 3.3% in sm (submucosal cancer) 1 group and 22.6% in sm 2 group. In sm 2 group, lymph node extirpation of R2 is essential. The five year ...

journal_title：Anticancer research

authors： Kito T,Yamamura Y,Kobayashi S

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:The prognosis for advanced gastric cancer with paraaortic lymph node (PALN) metastasis is very poor even after a curative resection. In the present study, induction chemotherapy followed by curative surgery was performed for advanced gastric cancer with PALN metastasis. PATIENTS AND METHODS:Twenty patients ...

journal_title：Anticancer research

authors： Fujiwara Y,Omori T,Demura K,Miyata H,Sugimura K,Ohue M,Kobayashi S,Takahashi H,Doki Y,Yano M

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:The successful use of clonal selection through fluctuation analysis of human cancer cells as a means for studying tumor progression has been previously reported. MATERIALS AND METHODS:Three clones derived from a parental population of human prostate cancer (LNCaP) cells were selected based on proliferation,...

journal_title：Anticancer research

authors： Ware JH,Zhou Z,Kopelovich L,Kennedy AR

更新日期：2006-11-01 00:00:00

abstract：:The generation of MHC-unrestricted cytotoxicity of highly enriched human CD3+ T cells (95-99%) by treatment with IL-2 and/or anti-CD3 antibodies was studied. T cells obtained by positive immunomagnetic sorting (anti-CD3) developed comparable specific cytotoxicities against K562 and Daudi cells when cultured with IL-2 ...

journal_title：Anticancer research

authors： Zollner TM,Zhu HG,Anderer FA

更新日期：1993-07-01 00:00:00

abstract：:A consecutive series of 128 breast cancer patients detected by breast screening were enrolled in this study to analyze their age-dependent characteristics. They were classified into three groups; 40 years or less (young): 26 patients, 41-55 years (middle-aged): 67 patients and 56 years or over (old): 35 patients. The ...

journal_title：Anticancer research

authors： Takei H,Iino Y,Horiguchi J,Maemura M,Koibuchi Y,Horii Y,Nagaoka H,Matsumoto H,Ishikita T,Yokoe T,Morishita Y

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND/AIM:In a previous study, we showed that amentoflavone promotes sorafenib-induced apoptosis in hepatocellular carcinoma (HCC) cells in vitro. However, whether amentoflavone augments anticancer efficacy of sorafenib in HCC in vivo is unknown. The aim of the present study was to verify the anticancer effect of ...

journal_title：Anticancer research

authors： Tsai JJ,Hsu FT,Pan PJ,Chen CW,Kuo YC

更新日期：2018-04-01 00:00:00

abstract：:Between 1975 and 1982, 202 previously untreated patients with multiple myeloma (MM) and clinical evidence of disease progression received intensive chemotherapy every 3-5 weeks to induce remission. Treatment regimen included intermittent courses of a combination of cycle non-specific drugs (melphalan, cyclophosphamide...

journal_title：Anticancer research

authors： Bataille R,Souteyrand P,Sany J

更新日期：1984-11-01 00:00:00

abstract：BACKGROUND/AIM:FAM92A1-289 is recognized as one of the newly-discovered putative oncogenes. This study was performed to reveal its oncogenic functions in human cervical carcinoma cells. MATERIALS AND METHODS:The FAM92A1-289+ cell line was established with knock-in technique and selected by puromycin-resistance screeni...

journal_title：Anticancer research

authors： Gui H,Guo XR,Fang J,Ma SN,Wu G,Shen JH,Tu HJ,Li DS,Dai LJ,Ruan XZ

更新日期：2016-10-01 00:00:00

abstract：:Between 1981 and 1987, 533 patients from 9 institutions were entered in a randomized trial to assess the value of adjuvant perioperative portal infusion with Fluorouracil and Mitomycin as compared to radical surgery alone. Analysis of 469 evaluable patients at a median follow-up of 5.8 years revealed 110 recurrences i...

journal_title：Anticancer research

authors： Weber W,Laffer U,Metzger U

更新日期：1993-09-01 00:00:00

abstract：AIM:The evaluation of toxicity after high-dose-rate interstitial brachytherapy (HDR-ISBT) as monotherapy for localized prostate cancer. MATERIALS AND METHODS:We analyzed early and late toxicities in 100 patients treated by HDR-ISBT as monotherapy at the National Hospital Organization Osaka National Hospital using both...

journal_title：Anticancer research

authors： Yoshida K,Yamazaki H,Nakamara S,Masui K,Kotsuma T,Akiyama H,Tanaka E,Yoshioka Y

更新日期：2014-04-01 00:00:00

abstract：UNLABELLED:We investigated the predictive value of the protein S100 as a tumor-marker in the post-surgical follow-up staging of patients with High Risk melanomas (Clark Levels IV/V, Thickness > 0.75 mm). METHODS:In 51 follow-up studies, performed in 50 patients, serum concentrations of the protein S100 were measured a...

journal_title：Anticancer research

authors： Mruck S,Baum RP,Rinne D,Hör G

更新日期：1999-07-01 00:00:00

abstract：:In the clinical setting, administration of high daily or bolus doses of vitamin D is often solely based on 25-hydroxyvitamin D [25(OH)D] testing. This review summarizes the evidence of the effect of vitamin D on cardiovascular disease (CVD). Meta-analyses of randomized controlled trials (RCTs) have demonstrated that C...

journal_title：Anticancer research

authors： Zittermann A,Pilz S

更新日期：2019-09-01 00:00:00

abstract：:Squamous cell carcinomas (SCC) make up 96% of all oral cancers. Most laboratory SCC studies grow cells as a monolayer, which does not accurately represent the disease in vivo. We used a more relevant multicellular spheroid (MCS) model to study this disease. The SCC9β6KDFyn cell line, which expresses full-length β6 and...

journal_title：Anticancer research

authors： Lee C,Lee C,Atakilit A,Siu A,Ramos DM

更新日期：2014-12-01 00:00:00

abstract：:Despite the advances in the detection and treatment of lung cancer, the overall 5-year survival is only 10-20%. Accumulating evidence suggests that verapamil, a calcium channel antagonist, is a potential anticancer agent. Epidermal growth factor receptor (EGFR) is a key therapeutic target in many types of cancer, wher...

journal_title：Anticancer research

authors： Zhang C,Lv F,Zhou L,Li X,Wu XX,Hoffman RM

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIM:Basaloid squamous cell carcinoma of the oesophagus (BSCCE) is a variant of oesophageal squamous cell carcinoma (ESCC), that has a more aggressive biological behaviour than that of typical ESCC. miR-3687 has been previously identified to be highly expressed in BSCCE. This study aimed to evaluate the progn...

journal_title：Anticancer research

authors： Hagio K,Furuya S,Nakamura J,Maruyama S,Shiraishi K,Shimizu H,Akaike H,Hosomura N,Kawaguchi Y,Amemiya H,Kawaida H,Sudo M,Inoue S,Kono H,Ichikawa D

更新日期：2019-02-01 00:00:00

abstract：:A new transitional cell carcinoma cell line, BCCA-1, derived from a primary urinary bladder carcinoma, was characterized with respect to the growth patterns of in vitro culture, xenotransplantability in SCID mice and immunophenotypic profile. The most unusual finding was a strong tendency of forming many aggregates (m...

journal_title：Anticancer research

authors： Chuang CK,Liao SK

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND/AIM:Despite an expected prognostic disadvantage for upper tract versus lower tract metastatic urothelial carcinomas (UTUC/LTUC), only few studies have been conducted to elucidate potential differences in chemotherapy treatment. PATIENTS AND METHODS:A post-hoc subgroup analysis of a non-interventional study ...

journal_title：Anticancer research

authors： Heers H,DE Geeter P,Goebell PJ,Matz U,DE Schultz W,Edlich B,Retz M,Hegele A

更新日期：2017-11-01 00:00:00

abstract：AIM:To determine whether concentrations of the angiogenic growth factors hepatocyte growth factor (HGF) and vascular endothelial growth factor A (VEGF-A) correlate with clinical and genetic markers in samples taken at diagnosis in children with neuroblastoma (NB). PATIENTS AND METHODS:Heparin plasma (P-) and serum (S-...

journal_title：Anticancer research

authors： Sköldenberg EG,Larsson A,Jakobson A,Hedborg F,Kogner P,Christofferson RH,Azarbayjani F

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND/AIM:Although the advent of Helicobacter pylori eradication and global societal changes are widely assumed to impact on gastric cancer (GC)-related mortality, there is remarkable little quantitative and qualitative insight into the nature of its effects. Here, we exploited a nationwide reporting system to inv...

journal_title：Anticancer research

authors： Yin J,Song JN,Bai ZG,Cai J,Zhang J,Zheng Z,Wu HW,Ye PP,Gao X,Zhang ZT

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Chemotherapy sensitivity of soft-tissue sarcomas (STS) is limited, which may be due to multidrug resistance (MDR). MDR is associated with expression of P-glycoprotein (P-gp), Multidrug Resistance-associated Protein 1 (MRP1) and Lung Resistance-related Protein (LRP). It is unknown whether in STS metastasis is...

journal_title：Anticancer research

authors： Komdeur R,Molenaar WM,Zwart N,Hoekstra HJ,van den Berg E,van der Graaf WT

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:We hypothesized that ancestry-mediated methylated DNA changes may drive racial and ethnic disparity in prostate cancer (PCa). To test this hypothesis, we analyzed genetic ancestry and association with DNA methylation changes in PCa disparity. MATERIALS AND METHODS:Pyrosequencing and ancestry informative mar...

journal_title：Anticancer research

authors： Apprey V,Wang S,Tang W,Kittles RA,Southerland WM,Ittmann M,Kwabi-Addo B

更新日期：2019-11-01 00:00:00

abstract：:Human leukocyte antigen (HLA)-E and HLA-F are classified as non-classical HLA class Ib antigens. Ectopic HLA-E and HLA-F expression was recently detected in cancer cells; however, the clinical implication of their expression remains unknown. A total of 209 patients with gastric cancer were enrolled in this study. Immu...

journal_title：Anticancer research

authors： Ishigami S,Arigami T,Okumura H,Uchikado Y,Kita Y,Kurahara H,Maemura K,Kijima Y,Ishihara Y,Sasaki K,Uenosono Y,Natsugoe S

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Cancer stem cells (CSCs) have a high tumorigenic ability to form patient-derived tumor xenografts (PDXs). PDXs are an attractive pre-clinical model, but gene expression and biological behavior of cancer cells in the tumor will change during establishment and passage of PDXs. MATERIALS AND METHODS:Human colo...

journal_title：Anticancer research

authors： Mukohyama J,Shimono Y,Yamashita K,Sumi Y,Mukohara T,Minami H,Kakeji Y

更新日期：2016-07-01 00:00:00