当前位置： SCI文献检索 > JOURNAL OF THROMBOSIS AND THROMBOLYSIS期刊下所有文献 > Structure-function relationships of factor Xa inhibitors: implications for the practicing clinician.

Structure-function relationships of factor Xa inhibitors: implications for the practicing clinician.

Abstract：

:The recent development and approval of novel oral anticoagulants represents a significant success in the intelligent design of target-specific therapeutics. However, while these agents obviate many of the shortcomings of their predecessor (warfarin), they present novel challenges in pharmacologic management as well. Each was designed to have high oral bioavailability and high affinity for its target molecule, conveying significant anticoagulant effects. Yet, such unique drug-ligand binding, coupled with unfamiliar drug interactions and renal-based clearance, represent challenges to clinical management. The current review describes the development and pharmacokinetic properties of these agents, in the context of their clinical utility and pitfalls.

journal_name

J Thromb Thrombolysis

journal_title

Journal of thrombosis and thrombolysis

authors

Steinberg BA,Becker RC

doi

10.1007/s11239-013-0991-z

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

234-41

issue

2

eissn

0929-5305

issn

1573-742X

journal_volume

37

pub_type

杂志文章,评审

相关文献

JOURNAL OF THROMBOSIS AND THROMBOLYSIS文献大全
  • Thrombolytic therapy in pregnancy.

    abstract：:Pregnancy due to its physiological changes is a procoagulant state. The rate of cardiac valve prosthesis thrombosis, deep venous thrombosis and pulmonary embolism are all increased. Thrombolytic therapy with tissue plasminogen activator (rt-PA) is an approved therapy for ischemic stroke, myocardial infarction, pulmona...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,评审

    doi：10.1007/s11239-006-5709-z

    authors： Leonhardt G,Gaul C,Nietsch HH,Buerke M,Schleussner E

    更新日期：2006-06-01 00:00:00

  • Is delayed facilitated percutaneous coronary intervention better than immediate in reperfused myocardial infarction? Six months follow up findings.

    abstract：BACKGROUND:There are several new strategies proposed to improve the outcome of patients with ST-elevation myocardial infarction (STEMI). One approach is the resurgent use of facilitated percutaneous coronary interventions (PCI). Until recently, deciding whether immediate PCI after combined treatment (facilitated PCI) i...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s11239-006-5733-z

    authors： Di Pasquale P,Cannizzaro S,Parrinello G,Giambanco F,Vitale G,Fasullo S,Scalzo S,Ganci F,La Manna N,Sarullo F,La Rocca G,Paterna S

    更新日期：2006-04-01 00:00:00

  • Platelet response to direct thrombin inhibitor or fondaparinux treatment in patients with suspected heparin-induced thrombocytopenia.

    abstract：:Making a definitive diagnosis of heparin-induced thrombocytopenia (HIT) can be problematic. A prompt platelet rise following treatment has been proposed as a "post-test" criterion for diagnosis. However, the platelet response following discontinuation of heparin and initiation of a recommended alternative anticoagulan...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s11239-018-1646-x

    authors： Pon TK,Mahajan A,Rosenberg A,Amin A,Shah D,Jenkins I,Gupta V,Hofmann H,Bejjani A,White R

    更新日期：2018-05-01 00:00:00

  • Development of a new catheter prototype for laser thrombolysis under guidance of optical coherence tomography (OCT): validation of feasibility and efficacy in a preclinical model.

    abstract：:In this feasibility study, a novel catheter prototype for laser thrombolysis under the guidance of optical coherence tomography (OCT) was designed and evaluated in a preclinical model. Human arteries and veins were integrated into a physiological flow model and occluded with thrombi made from the Chandler Loop. There ...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-016-1470-0

    authors： Berndt R,Rusch R,Hummitzsch L,Lutz M,Heß K,Huenges K,Panholzer B,Otte C,Haneya A,Lutter G,Schlaefer A,Cremer J,Groß J

    更新日期：2017-04-01 00:00:00

  • Extended-duration thromboprophylaxis in acutely ill medical patients with recent reduced mobility: methodology for the EXCLAIM study.

    abstract：BACKGROUND:Venous thromboembolism (VTE) is a significant cause of mortality and morbidity in medical patients. Although thromboprophylaxis with enoxaparin reduces the risk of VTE in these patients, the optimal duration of therapy is not currently known. The EXCLAIM (EXtended CLinical prophylaxis in Acutely Ill Medical ...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s11239-006-7732-5

    authors： Hull RD,Schellong SM,Tapson VF,Monreal M,Samama MM,Turpie AG,Wildgoose P,Yusen RD

    更新日期：2006-08-01 00:00:00

  • Impact of early abciximab administration on myocardial reperfusion in patients with ST-segment elevation myocardial infarction pretreated with 600 mg of clopidogrel before percutaneous coronary intervention.

    abstract：:Early rapid platelet inhibition with abciximab before primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI) is suggested as beneficial. In previous studies on early abciximab administration clopidogrel was administered in cathlab in low loading dose. We investigated t...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s11239-010-0461-9

    authors： Dudek D,Rakowski T,Bartus S,Giszterowicz D,Dobrowolski W,Zmudka K,Zalewski J,Ochala A,Wieja P,Janus B,Dziewierz A,Legutko J,Bryniarski L,Dubiel JS

    更新日期：2010-10-01 00:00:00

  • Acute Myocardial Infarction and the Role of Aspirin, Heparin, and Warfarin.

    abstract：:Acute myocardial infarction is initiated by plaque disruption of a fatty plaque with a thin fibrous cap which has been infiltrated by macrophages. The macrophages are attracted and stimulated by oxidized lipids to secrete metalloproteinases which dissolve collagen and arterial wall matrix and to synthesize tissue fact...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/BF01060732

    authors： Chesebro JH,Badimon JJ,Hassinger NL,McBane RD,Fuster V V

    更新日期：1995-01-01 00:00:00

  • Use of oral anticoagulant drugs is associated with carotid intraplaque hemorrhage in atherosclerosis patients: a meta-analysis.

    abstract：:Patients with carotid atherosclerosis, especially the elderly population, take antithrombotic medicine regularly. However, no previous meta-analysis has focused on one of the possible side effects of such drugs, namely intraplaque hemorrhage (IPH). To determine whether antiplatelet drugs or anticoagulants are associat...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,meta分析

    doi：10.1007/s11239-019-01865-2

    authors： Cao X,Zhang J,Geng D

    更新日期：2019-07-01 00:00:00

  • The impact of a pulmonary embolism response team on the efficiency of patient care in the emergency department.

    abstract：:The concept of a pulmonary embolism response team (PERT) is multidisciplinary, with the hope that it may positively impact patient care, hospital efficiency, and outcomes in the treatment of patients with intermediate and high risk pulmonary embolism (PE). Clinical characteristics of a baseline population of patients ...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-019-01875-0

    authors： Wright C,Elbadawi A,Chen YL,Patel D,Mazzillo J,Acquisto N,Groth C,Van Galen J,Delehanty J,Pietropaoli A,Trawick D,James White R,Cameron P,Gosev I,Barrus B,Kumar NG,Cameron SJ

    更新日期：2019-08-01 00:00:00

  • Multiple and recurrent systemic thrombotic events associated with congenital anomaly of inferior vena cava.

    abstract：:We describe a case of a 67-year-old woman with a history of cerebral infarction and pulmonary embolism that presented with chest pain. Subsequent evaluation resulted in a diagnosis of acute myocardial infarction and occult DVT, and imaging revealed a rare congenital absence of the infra-renal portion of the inferior v...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-005-1380-z

    authors： Takehara N,Hasebe N,Enomoto S,Takeuchi T,Takahashi F,Ota T,Kawamura Y,Kikuchi K

    更新日期：2005-04-01 00:00:00

  • Incidence and outcomes of catheter related thrombosis (CRT) in patients with acute leukemia using a platelet-adjusted low molecular weight heparin regimen.

    abstract：:Patients with acute leukemia frequently develop catheter-related thrombosis (CRT) despite concurrent thrombocytopenia. The incidence, treatment and outcomes of this complication are poorly documented. We undertook this study to determine the incidence of CRT in patients with acute leukemia and assess the safety and ef...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-018-1711-5

    authors： Htun KT,Ma MJY,Lee AYY

    更新日期：2018-10-01 00:00:00

  • Low levels of activated factor VII in systemic sclerosis.

    abstract：INTRODUCTION:Recent investigations show that activated factor VII, the primary enzyme in the extrinsic pathway of blood coagulation, exerts additional extra-coagulant functions, such as apoptosis and angiogenesis. On the basis of these recent acquisitions, the present study was aimed to evaluate activated factor VII in...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-006-8969-8

    authors： Volpe A,Salvagno GL,Lippi G,Caramaschi P,Montagnana M,Canestrini S,Carletto A,Bambara LM,Biasi D,Guidi GC

    更新日期：2006-10-01 00:00:00

  • Determining the efficacy of antiplatelet therapies for the individual: lessons from clinical trials.

    abstract：:This article focuses on lessons learned from clinical trials of antiplatelet therapies-in particular, that the degree of inhibition of ex vivo platelet aggregation does not necessarily directly translate into clinical efficacy. As an example, the case of the oral platelet glycoprotein IIb/IIIa inhibitors is presented,...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-007-0160-3

    authors： Steinhubl SR,Schneider DJ,Berger PB,Becker RC

    更新日期：2008-08-01 00:00:00

  • The lack of endothelization after drug-eluting stent implantation as a cause of fatal late stent thrombosis.

    abstract：:The authors present a fatal case of late thrombosis of paclitaxel-eluting stent implanted in the left main stem occurring 6 months after the procedure and 3 weeks after the cessation of clopidogrel. An autopsy has shown the lack of endothelization of deployed stent. ...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-007-0080-2

    authors： Jakabcin J,Bystron M,Spacek R,Veselka J,Kvasnak M,Kala P,Malý J,Cervinka P

    更新日期：2008-10-01 00:00:00

  • Efficacy and safety of rivaroxaban on the resolution of left atrial/left atrial appendage thrombus in nonvalvular atrial fibrillation patients.

    abstract：:Data on LA/LAA thrombus resolution after rivaroxaban treatment has not been established. The aim of the present study was to compare the efficacy and safety on the resolution of LA/LAA thrombus between rivaroxaban and warfarin in nonvalvular atrial fibrillation (AF) patients. 80 AF patients with LA/LAA thrombus betwee...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s11239-019-01876-z

    authors： Ke HH,He Y,Lv XW,Zhang EH,Wei Z,Li JY

    更新日期：2019-08-01 00:00:00

  • Reasons for exclusion from intravenous thrombolysis in stroke patients admitted to the Stroke Unit.

    abstract：:Intravenous (IV) thrombolysis is the treatment in ischemic stroke, but only the minority of patients receive this medication. The primary objective of this study was to explore the reasons associated with the decision not to offer IV thrombolysis to stroke patients admitted to the Stroke Unit (SU). We conducted a retr...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-016-1406-8

    authors： Cappellari M,Bosco M,Forlivesi S,Tomelleri G,Micheletti N,Carletti M,Bovi P

    更新日期：2016-11-01 00:00:00

  • Patients with perceived high-bleeding risk and computerized decision support for stroke prevention in atrial fibrillation: an AF-ALERT substudy : Piazza: outcomes of high-bleeding risk AF patients.

    abstract：:A perceived increased risk of bleeding is one of the most frequent reasons for withholding anticoagulation for stroke prevention in atrial fibrillation (AF). We previously conducted a randomized controlled trial of alert-based computerized decision support to increase prescription of anticoagulation in hospitalized pa...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-020-02296-0

    authors： Piazza G,Hurwitz S,Carroll B,Goldhaber SZ

    更新日期：2020-09-30 00:00:00

  • Fever and deep venous thrombosis. Findings from the RIETE registry.

    abstract：:Fever is a presenting sign in some patients with acute deep venous thrombosis (DVT), but its influence on outcome has not been thoroughly investigated. RIETE is an ongoing, international, observational registry of consecutive patients with symptomatic, objectively confirmed, acute venous thromboembolism. The aim of th...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1007/s11239-011-0604-7

    authors： Barba R,Di Micco P,Blanco-Molina A,Delgado C,Cisneros E,Villalta J,Morales MV,Bura-Riviere A,Debourdeau P,Monreal M

    更新日期：2011-10-01 00:00:00

  • Evaluation of direct oral anticoagulants for the treatment of cancer-associated thrombosis: an update.

    abstract：:Cancer is associated with an increased risk of venous thromboembolism of four to sixfold. Cancer-related interventions such as chemotherapy, hormonal therapy and indwelling central venous catheters also increase the risk of venous thromboembolism. Low molecular weight heparin for at least 3-6 months is the current sta...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,评审

    doi：10.1007/s11239-018-1783-2

    authors： Franco-Moreno A,Cabezón-Gutiérrez L,Palka-Kotlowsa M,Villamayor-Delgado M,García-Navarro M

    更新日期：2019-04-01 00:00:00

  • Dabigatran versus warfarin major bleeding in practice: an observational comparison of patient characteristics, management and outcomes in atrial fibrillation patients.

    abstract：:Data comparing the patient characteristics, management and outcomes for dabigatran versus warfarin major bleeding in the practice setting are limited. We performed a retrospective single health system study of atrial fibrillation patients with dabigatran or warfarin major bleeding from October 2010 through September 2...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-015-1213-7

    authors： Smythe MA,Forman MJ,Bertran EA,Hoffman JL,Priziola JL,Koerber JM

    更新日期：2015-10-01 00:00:00

  • Aspirin resistance and genetic polymorphisms.

    abstract：:Differences in genetic makeup or polymorphisms can affect individual drug response. Detecting genetic variation may help predict how a patient will respond to a drug and could be used as a tool to select optimal therapy, tailor dosage regimens, and improve clinical outcomes. The data are replete relative to the therap...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,评审

    doi：10.1023/a:1022066305399

    authors： Cambria-Kiely JA,Gandhi PJ

    更新日期：2002-08-01 00:00:00

  • Effect of Poloxamer 188 on Collateral Blood Flow, Myocardial Infarct Size, and Left Ventricular Function in a Canine Model of Prolonged (3-Hour) Coronary Occlusion and Reperfusion.

    abstract：:Poloxamer 188 is a surfactant with hemorheological, antithrombotic, and neutrophil-inhibitory properties. This agent has been demonstrated to reduce infarct size and to improve left ventricular function in animal models of myocardial infarction and reperfusion, and recently in a randomized trial of patients receiving ...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1023/A:1008848026759

    authors： Kelly RF,Hursey TL,Patel RB,Parrillo JE,Schaer GL

    更新日期：1998-07-01 00:00:00

  • The effect of the REG2 Anticoagulation System on thrombin generation kinetics: a pharmacodynamic and pharmacokinetic first-in-human study.

    abstract：:The REG2 Anticoagulation System consists of pegnivacogin, a subcutaneously administered aptamer factor IXa inhibitor, and its intravenous active control agent, anivamersen. Its effect on thrombin generation is unknown. A prospectively designed thrombin generation study was conducted within the phase 1 ascending dose s...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s11239-014-1081-6

    authors： Vavalle JP,Rusconi CP,Zelenkofske S,Wargin WA,Ortel TL,Alexander JH,Povsic TJ,Becker RC

    更新日期：2014-10-01 00:00:00

  • Performance of the right ventricular outflow tract/aortic diameter as a novel predictor of risk in patients with acute pulmonary embolism.

    abstract：:Right ventricular (RV) enlargement, determined via the ratio of the right to left ventricular diameters (RV/LV) by CT imaging is used to classify the severity of acute pulmonary embolism (PE) and impacts treatment decisions. The RV/LV ratio may be an unreliable marker of RV dysfunction, due in part to the complex RV g...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-019-02021-6

    authors： Marginean A,Putnam A,Hirai T,Serritella A,Besser SA,Lee M,Friant J,Blair J,Shah A,Nathan S,Chung J,Paul J

    更新日期：2020-07-01 00:00:00

  • Are surgical patients at risk of venous thromboembolism currently meeting the Surgical Care Improvement Project performance measure for appropriate and timely prophylaxis?

    abstract：:The US Surgical Care Improvement Project (SCIP) has approved two performance measures to improve venous thromboembolism (VTE) prevention. SCIP-VTE-2 measures the proportion of surgery patients who received appropriate VTE prophylaxis within 24 h prior to surgery to 24 h after surgery. This study assesses the current r...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-009-0393-4

    authors： Deitelzweig SB,Lin J,Hussein M,Battleman D

    更新日期：2010-07-01 00:00:00

  • Characteristic and prognosis of acute large vessel occlusion in anterior and posterior circulation after endovascular treatment: the ANGEL registry real world experience.

    abstract：:There were limited studies comparing the anterior (AC) and posterior (PC) circulation acute ischemic strokes (AIS). Our study aimed to evaluate distinct features of AC and PC strokes regarding clinical, vascular risk, pathogenesis and outcome factors after endovascular procedures. This multicenter prospective study re...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-020-02054-2

    authors： Huo X,Raynald,Gao F,Ma N,Mo D,Sun X,Song L,Jia B,Pan Y,Wang Y,Liu L,Zhao X,Wang Y,Miao Z,ANGEL investigators.

    更新日期：2020-05-01 00:00:00

  • M118, a novel low-molecular weight heparin with decreased polydispersity leads to enhanced anticoagulant activity and thrombotic occlusion in ApoE knockout mice.

    abstract：:Heparin and low-molecular weight heparin (LMWH) are complex, heterogeneous polysaccharides used in the treatment of arterial and venous thrombosis. M118 is a novel LMWH with low polydispersity and pronounced anti-Xa and anti-thrombin (IIa) activity as compared to current LMWHs. To determine if M118 is effective in pre...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-009-0340-4

    authors： Chakrabarti S,Beaulieu LM,Reyelt LA,Iafrati MD,Freedman JE

    更新日期：2009-11-01 00:00:00

  • Mechanisms of venous and arterial thrombosis in heparin-induced thrombocytopenia.

    abstract：:Since the reports by Weismann and Tobin in 1958 and Roberts et al. in 1964 called attention to paradoxical thrombosis in patients treated with heparin, the thrombotic aspect of the heparin-induced thrombocytopenia syndrome (HIT) has been emphasized. Yet to this day, the mechanism of thrombosis associated with HIT (HIT...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章,评审

    doi：10.1023/a:1027372901367

    authors： Walenga JM,Jeske WP,Messmore HL

    更新日期：2000-11-01 00:00:00

  • Prothrombotic genetic risk factors in patients with very early ST-segment elevation myocardial infarction.

    abstract：:The contribution of prothrombotic genetic risk factors in the pathogenesis of premature acute myocardial infarction (MI) is controversial. We examined the prevalence of prothrombotic polymorphisms (G1691A of factor V gene [FV Leiden] and G20210A of prothrombin [FII] gene), deficiencies of natural anticoagulants (prote...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-017-1520-2

    authors： Rallidis LS,Gialeraki A,Tsirebolos G,Tsalavoutas S,Rallidi M,Iliodromitis E

    更新日期：2017-08-01 00:00:00

  • Prevalence of Factor V 1691 G-A (Leiden) and prothrombin G20210A polymorphisms and the risk of venous thrombosis among cancer patients.

    abstract：AIMS:Cancer patients have an increased risk for thromboembolism (TE). Factor V 1691 G-A(Leiden) (FVL) and prothrombin (PT) G20210A mutation are common inherited risk factor for TE. The aim of the study is to evaluate the prevalence of FVL and PT G20210A polymorphism in cancer patients with and without TE as compared to...

    journal_title：Journal of thrombosis and thrombolysis

    pub_type： 杂志文章

    doi：10.1007/s11239-006-9001-z

    authors： Eroglu A,Ulu A,Cam R,Kurtman C,Akar N

    更新日期：2007-02-01 00:00:00