Abstract:
:Adult males of the Wistar albino rats (Rattus norvegicus) were exposed to lead acetate trihydrate in drinking water (0.0%, 0.25%, 0.5%, 1% and 2% for 1-12 months) to investigate histological and histochemical alterations induced by lead intoxication in the liver. Chronic exposure to subtoxic concentrations of lead produced changes in the hepatocytes, portal triads and the sinusoids. The alterations in the hepatocytes were mainly anisokaryosis, nuclear vesiculation, binucleation, cytoplasmic inclusions, cytoplasmic swelling, hydropic degeneration, necrosis and reduction in glycogen content. In addition, portal triads mild chronic inflammation, Kupffer cells hyperplasia and occasional fatty change were seen together with hemosiderosis. No portal fibrosis or cirrhosis was detected due to chronic subtoxic doses of lead exposure in the liver of any member of the dose groups over the entire period of the study. Chronic lead exposure also increased the activities of alkaline phosphatase and α-glycerophosphate-dehydrogenase which might be an adaptation to the metabolic, structural and functional changes in the organelles of hepatic cells due to lead intoxication. The findings revealed that chronic exposure to lead produced significant histological and histochemical changes in the liver of the Wistar albino rats.
journal_name
Saudi J Biol Scijournal_title
Saudi journal of biological sciencesauthors
Jarrar BM,Taib NTdoi
10.1016/j.sjbs.2011.12.005subject
Has Abstractpub_date
2012-04-01 00:00:00pages
203-10issue
2eissn
1319-562Xissn
2213-7106pii
SJBS149journal_volume
19pub_type
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journal_title:Saudi journal of biological sciences
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journal_title:Saudi journal of biological sciences
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
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journal_title:Saudi journal of biological sciences
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journal_title:Saudi journal of biological sciences
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更新日期:2015-07-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2017.03.009
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2009.07.005
更新日期:2009-07-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2017.08.010
更新日期:2018-03-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2018.10.012
更新日期:2019-11-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2012.05.003
更新日期:2012-07-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2018.12.003
更新日期:2019-02-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.sjbs.2019.05.004
更新日期:2019-09-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2015.05.001
更新日期:2016-05-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2018.03.006
更新日期:2019-11-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2015.10.005
更新日期:2016-01-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2020.10.016
更新日期:2021-01-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2015.10.010
更新日期:2016-01-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2020.05.006
更新日期:2020-09-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2015.06.009
更新日期:2015-11-01 00:00:00
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journal_title:Saudi journal of biological sciences
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2017.11.009
更新日期:2017-12-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2018.08.006
更新日期:2019-07-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2015.01.007
更新日期:2015-09-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2020.10.053
更新日期:2021-01-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2020.09.006
更新日期:2020-11-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2018.01.011
更新日期:2018-07-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2018.01.007
更新日期:2019-09-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2014.09.016
更新日期:2015-05-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2015.10.006
更新日期:2016-01-01 00:00:00