Abstract:
:Using positron emission tomography (PET), we studied physiological changes in a patient with frontal lobe damage resulting from closed head injury by assessing his regional cerebral blood flow (rCBF) pattern relative to that of his uninjured monozygotic (MZ) cotwin and against normal variability between cotwins in 10 comparably-aged, uninjured MZ twin pairs. rCBF was measured during the Wisconsin Card Sorting Test (WCST) and a sensorimotor control task. Differences between the index twins in rCBF activation (WCST-control) in regions determined on coplanar MRIs were compared to within-pair differences in the control group using the Z-statistic. Activation differences between the index twins extending beyond normal variability were found in two regions-relative to his uninjured cotwin, the injured twin showed less activation in the inferior portion of the left inferior frontal gyrus while showing greater activation in the left hippocampus (P < 0.04). This pattern contrasts with that of normal subjects during WCST performance of augmented rCBF in the prefrontal cortex and not in the hippocampus. These rCBF differences appear to reflect the utilization of different neural systems when performing a frontal-lobe task. The use of the hippocampus by the injured twin might reflect an attempt to compensate for compromised frontal lobe functioning.
journal_name
Neuropsychologiajournal_title
Neuropsychologiaauthors
Kirkby BS,Van Horn JD,Ostrem JL,Weinberger DR,Berman KFdoi
10.1016/0028-3932(95)00147-6subject
Has Abstractpub_date
1996-07-01 00:00:00pages
689-97issue
7eissn
0028-3932issn
1873-3514pii
0028393295001476journal_volume
34pub_type
临床试验,杂志文章相关文献
NEUROPSYCHOLOGIA文献大全abstract::Lines of fish, Girardinus falcatus preferentially turning rightward (RD) or leftward (LD) when facing a dummy predator visible behind a barrier have been obtained through selective breeding. To check whether lateralization was maintained in other behavioral responses, five different tests were carried out. They compri...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/s0028-3932(01)00034-3
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:A deficit in remembering the temporal context of events (a type of source memory) has been observed in schizophrenia, and suggested to be associated with positive symptoms. METHODS:In order to investigate memory for temporal context, we administered a list discrimination task to a sample of schizophrenia pa...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2006.08.009
更新日期:2007-03-02 00:00:00
abstract::The present study used the flanker task [Percept. Psychophys. 16 (1974) 143] to identify neural structures that support response selection processes, and to determine which of these structures respond differently depending on the type of stimulus material associated with the response. Participants performed two versio...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/s0028-3932(03)00040-x
更新日期:2003-01-01 00:00:00
abstract::Developmental dyslexia is strongly associated with a phonological deficit. Yet, implicit phonological processing (in)capacities in dyslexia remain relatively unexplored. Here we use a neurophysiological response sensitive to experience-dependent auditory memory traces, the mismatch negativity (MMN), to investigate imp...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2006.11.009
更新日期:2007-04-08 00:00:00
abstract::Determinants of inter- and intrahemispheric organization following left focal injury were examined with data deriving from four different studies that used three different assessment methods (amobarbital, temporal lobectomy, dichotic listening). With regard to interhemispheric reorganization, the results revealed that...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(88)90087-5
更新日期:1988-01-01 00:00:00
abstract::Autism spectrum disorders (ASDs) are characterised by a relatively specific pattern of typical and atypical memory functioning. Convergent behavioural and neuroscientific evidence indicates that this pattern of functioning may be the result of specific impairments in hippocampally mediated relational memory processes,...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2007.11.011
更新日期:2008-03-07 00:00:00
abstract::Understanding memory mechanisms is crucial in the study of infant social and cognitive development. Here, we show that the Nc ERP component, known to reflect frequency-related attentional and/or memory processes, is a good candidate to investigate infant recognition memory. Previous paradigms have only investigated th...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2017.08.023
更新日期:2019-03-18 00:00:00
abstract::Neglect patients are not aware of stimuli in the contralesional space. We aimed to simulate neglect-like behaviour in healthy participants, by asking them to orient their visuospatial attention in two conditions: non-hypnotic suggestion and post-hypnotic suggestion. Results showed that directing visuospatial attention...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2011.08.008
更新日期:2011-10-01 00:00:00
abstract::Stroke of the right cerebral hemisphere often causes deficits in the judgement of the subjective visual vertical (SVV) and subjective tactile vertical (STV) which are related to central vestibular functioning. Clinically, deficits in the SVV/STV are linked to balance problems and poor functional outcome. Galvanic Vest...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2015.03.004
更新日期:2015-07-01 00:00:00
abstract::With respect to what frames of reference, or spatial coordinate systems, is attention allocated to locations in space? We posed this question about the spatial attention system that has been damaged in neglect patients, distinguishing among three possible types of spatial reference frame: viewer-centered, according to...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(90)90060-2
更新日期:1990-01-01 00:00:00
abstract::Difficulties with verbal fluency tasks (VFIT) have been shown mainly to be associated with left frontal lobe pathology in lesion studies. The design fluency test (DFT) is a non-verbal analogue of word fluency tasks and has, in patients with right frontal lobe pathology, been coupled to an inability to perform well. Re...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/s0028-3932(97)00146-2
更新日期:1998-06-01 00:00:00
abstract::The involvement of the frontal cortex and thalamic nucleus in odor discrimination in humans was assessed. Six patients with frontal lobe brain damage, seven patients with alcoholic Korsakoff's syndrome and 16 healthy comparison subjects completed odor detection and odor discrimination tasks. Multivariate general linea...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/s0028-3932(01)00167-1
更新日期:2002-01-01 00:00:00
abstract::We use a unique environment of Whole Body Perceptual Deprivation (WBPD) to induce an altered state of consciousness (ASC) in our participants, and employ online EEG recording. We present individual EEG alpha profiles, and show how these data can be analyzed at the individual level. Our goal is to investigate to what d...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2019.01.018
更新日期:2019-03-04 00:00:00
abstract::Although an enhancing effect of reward on cognitive performance has been observed consistently, its neural underpinnings remain elusive. Recent evidence suggests that the inferior frontal junction (IFJ) may be a key player underlying such an enhancement by integrating motivational processes and cognitive control. Howe...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2019.01.016
更新日期:2019-03-04 00:00:00
abstract::Previous non-invasive studies have proposed that the deeply seated region of the medial frontal cortex engages in conflict processing in humans, but its core region has remained to be elucidated. By means of direct cortical stimulation, which excels other techniques in temporal and spatial resolutions and in the capac...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2013.02.002
更新日期:2013-04-01 00:00:00
abstract::Appreciation of metaphoric and nonmetaphoric alternative word meanings was assessed in 19 aphasic, left (LHD) and 15 non-aphasic, right (RHD) hemisphere brain-damaged stroke patients. With the one exception in the aphasic group, all patients were male. In an unspeeded sorting task, subjects responded on the basis of l...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(90)90063-t
更新日期:1990-01-01 00:00:00
abstract::The aim of the present study was to examine the mechanisms of empathy for pain that contribute to consoling touch, a distress-alleviating contact behavior carried out by an observer in response to the suffering of a target. We tested romantic couples in a paradigm that involves consoling touch and examined the attenua...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2017.04.026
更新日期:2018-07-31 00:00:00
abstract::The pervasiveness of word-finding difficulties in aphasia has motivated several theories regarding management of the deficit and its effectiveness. Recently, the hypothesis was advanced that instead of simply accompanying speech gestures participate in language production by increasing the semantic activation of words...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2010.09.025
更新日期:2010-11-01 00:00:00
abstract::Event-related potentials (ERPs) were recorded during a task which required subjects to discriminate between rhyming and non-rhyming visually presented pairs of letter strings, consisting of equal proportions of word-word and word-non-word combinations. Pair members were presented sequentially with an interstimulus int...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(84)90038-1
更新日期:1984-01-01 00:00:00
abstract::In this paper we report findings which question the diagnosis of a hemianopia in B.Q., a 66-year-old lady who shows unilateral spatial neglect following a lesion to the right parietal lobe. The presence of a hemianopia has been indicated following two independent assessments of B.Q.'s visual fields. We examined B.Q.'s...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(91)90065-g
更新日期:1991-01-01 00:00:00
abstract::Slow wave ERPs were recorded from 28 young adults as they generated plans for various difficulty levels of a fixed-foreperiod version of the Tower of London task. The resulting waveform included three segments: (1) a left-lateralized negative early-interval wave, which was frontally maximal but not sensitive to diffic...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2011.02.025
更新日期:2011-04-01 00:00:00
abstract::Theories of morphological processing differ on the issue of how lexical and grammatical information are stored and accessed. A key point of contention is whether complex forms are decomposed during recognition (e.g., establish+ment), compared to forms that cannot be analyzed into constituent morphemes (e.g., apartment...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2010.11.027
更新日期:2011-01-01 00:00:00
abstract::We investigated the neural basis of newly learned words in Spanish as a mother tongue (L1) and English as a second language (L2). Participants acquired new names for real but unfamiliar concepts in both languages over the course of two days. On day 3, they completed a semantic categorization task during fMRI scanning....
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2020.107703
更新日期:2020-12-09 00:00:00
abstract::Since Japanese learn the multiplication tables by means of mnemonic rhymes called kuku, i.e., via the auditory-speaking route, it is hypothesized that aphasics who have a deficit in kuku might relearn it via the visual-writing route. After having ordinary language therapy for more than 3 months, eight patients were ad...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(87)90032-7
更新日期:1987-01-01 00:00:00
abstract::The magnitude dimensions of number, time and space have been suggested to share some common magnitude processing, which may imply symmetric interaction among dimensions. Here we challenge these suggestions by presenting a double dissociation between two neuropsychological patients with left (JT) and right (CB) parieta...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2011.07.014
更新日期:2011-09-01 00:00:00
abstract::Coordinated brain activity between individuals, or inter-brain synchrony, has been shown to increase during cooperation and correlate with cooperation success. However, few studies have examined parent-child inter-brain synchrony and whether it is associated with meaningful aspects of the parent-child relationship. He...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2018.12.021
更新日期:2019-02-18 00:00:00
abstract::Left unilateral spatial neglect resulting from right brain damage is characterized by loss of awareness for stimuli in the contralesional side of space, despite intact visual pathways. We examined using fMRI whether patients with neglect are more likely to consciously detect in the neglected hemifield, emotionally neg...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2011.08.006
更新日期:2011-10-01 00:00:00
abstract::We studied a male with acquired prosopagnosia using a battery of Implicit Association Tests (IATs) to investigate whether observing faces varying by social category would activate the patient's implicit social biases. We also asked him to categorize faces explicitly by race, gender, and political party. The patient, G...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2011.03.009
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:Individuals with reduced olfactory function (anosmia, hyposmia) have reported changes in disgust perception and disgust experience compared to normosmic controls. The current functional magnetic resonance imaging (fMRI) study investigated the neural underpinnings of the altered disgust processing. METHOD:Tw...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2020.107411
更新日期:2020-04-01 00:00:00
abstract::In vivo occipital asymmetry (OA) measurements have been used to infer functional asymmetries such as language dominance. We investigated the degree of correlation between OA measurements derived by the same rater from different scans of the same subject. We used magnetic resonance (MR) and computerized axial tomograph...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(94)90122-8
更新日期:1994-12-01 00:00:00