Odor discrimination in patients with frontal lobe damage and Korsakoff's syndrome.

Abstract:

:The involvement of the frontal cortex and thalamic nucleus in odor discrimination in humans was assessed. Six patients with frontal lobe brain damage, seven patients with alcoholic Korsakoff's syndrome and 16 healthy comparison subjects completed odor detection and odor discrimination tasks. Multivariate general linear modeling with age as a covariant revealed significantly decreased odor discrimination ability in frontal lobe damaged patients and marginally decreased odor discrimination ability in Korsakoff's syndrome patients as compared to the healthy comparison subjects. No deficits were found in odor detection ability. The findings suggest that in human odor discrimination, there is more involvement of cortico-cortical pathways than of thalamo-cortical pathways.

journal_name

Neuropsychologia

journal_title

Neuropsychologia

authors

Hulshoff Pol HE,Hijman R,Tulleken CA,Heeren TJ,Schneider N,van Ree JM

doi

10.1016/s0028-3932(01)00167-1

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

888-91

issue

7

eissn

0028-3932

issn

1873-3514

pii

S0028393201001671

journal_volume

40

pub_type

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