Abstract:
:Increased neutrophil activation significantly contributes to the tissue damage in inflammatory illnesses; this phenomenon has motivated the search for new compounds to modulate their effector functions. Coumarins are natural products that are widely consumed in the human diet. We have evaluated the antioxidant and immunomodulator potential of five 4-methylcoumarin derivatives. We found that the 4-methylcoumarin derivatives inhibited the generation of reactive oxygen species by human neutrophils triggered by serum-opsonized zymosan or phorbol-12-myristate-13-acetate; this inhibition occurred in a concentration-dependent manner, as revealed by lucigenin- and luminol-enhanced chemiluminescence assays. Cytotoxicity did not mediate this inhibitory effect. The 7,8-dihydroxy-4-methylcoumarin suppressed the neutrophil oxidative metabolism more effectively than the 6,7- and 5,7-dihydroxy-4-methylcoumarins, but the 5,7- and 7,8-diacetoxy-4-methylcoumarins were less effective than their hydroxylated counterparts. An analysis of the biochemical pathways suggested that the 6,7- and 7,8-dihydroxy-4-methylcoumarins inhibit the protein kinase C-mediated signaling pathway, but 5,7-dihydroxy-4-methylcoumarin, as well as 5,7- and 7,8-diacetoxy-4-methylcoumarins do not significantly interfere in this pathway of the activation of the human neutrophil oxidative metabolism. The 4-methylcoumarin derivatives bearing the catechol group suppressed the elastase and myeloperoxidase activity and reduced the 1,1-diphenyl-2-picrylhydrazyl free radical the most strongly. Interestingly, the 5,7-dihydroxy-4-methylcoumarin scavenged hypochlorous acid more effectively than the o-dihydroxy-substituted 4-methylcoumarin derivatives, and the diacetoxylated 4-methylcoumarin derivatives scavenged hypochlorous acid as effectively as the 7,8-dihydroxy-4-methylcoumarin. The significant influence of small structural modifications in the inhibitory potential of 4-methylcoumarin derivatives on the effector functions of neutrophil makes them interesting candidates to develop new drugs for the treatment of inflammatory diseases mediated by increased neutrophil activation.
journal_name
J Med Foodjournal_title
Journal of medicinal foodauthors
Kabeya LM,Fuzissaki CN,Andrade MF,Azzolini AE,Taleb-Contini SH,Vermelho RB,Lopes JL,Lucisano-Valim YMdoi
10.1089/jmf.2012.0184subject
Has Abstractpub_date
2013-08-01 00:00:00pages
692-700issue
8eissn
1096-620Xissn
1557-7600journal_volume
16pub_type
杂志文章abstract::In this study, we investigated the antioxidant and protective effect of Lindera glauca stem (LGS) extracts against oxidative stress. We compared antioxidant properties of water extract (LGSW) with ethanol extract (LGSE) by determining the contents responsible for antioxidant activities such as polyphenols and flavonoi...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2018.4289
更新日期:2019-05-01 00:00:00
abstract::Periodontitis, an inflammatory disease of the gingival tissue, triggered by microbial-derived elements, such as lipopolysaccharide (LPS), collapses the periodontal tissues and resorbs the alveolar bone. This study evaluated the inhibitory effects of standardized Boesenbergia pandurata extract (BPE) and panduratin A (P...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2017.4155
更新日期:2018-10-01 00:00:00
abstract::We have previously demonstrated the hepatoprotective effect of Schisandra chinensis polysaccharides (SCP) against the liver injury induced by alcohol, high-fat diet, and carbon tetrachloride in mice. In this study, we investigated the effect of SCP against the immunological liver injury induced by concanavalin A (Con ...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2018.4377
更新日期:2019-09-01 00:00:00
abstract::The aim of this study is to select a lactic acid bacterial strain as a starter culture for flatfish-Sikhae fermentation and to evaluate its suitability for application in a food system. Four strains of lactic acid bacteria isolated from commercial flatfish-Sikhae were identified and selected as starter culture candida...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2015.3458
更新日期:2015-12-01 00:00:00
abstract::The effects of thyme (Thymus vulgaris L.) leaves and its phenolic compounds, thymol and carvacrol, on the activities of xenobiotic-metabolizing enzymes, i.e., phase I enzymes such as 7-ethoxycoumarin O-deethylase (ECOD) and phase II enzymes such as glutathione S-transferase (GST) and quinone reductase (QR), were inves...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2005.8.184
更新日期:2005-07-01 00:00:00
abstract::The aim of this study is to examine the in vitro antioxidant and antimicrobial activities of the acetone, methanol, and aqueous extracts of the lichens Cladonia furcata (many-forked Cladonia), Hypogymnia physodes (puffed lichen), and Umbilicaria polyphylla (manyleaf navel lichen) and the antimicrobial activity of fuma...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2010.0316
更新日期:2011-12-01 00:00:00
abstract::Aerial parts of Medicago sativa L. have been used as food and its consumption has been associated with health benefits, one among the most important being menopausal symptoms control. This work was aimed to explore possible pharmacological effects of two new alfalfa-derived products that have recently emerged as daily...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2016.0024
更新日期:2016-10-01 00:00:00
abstract::Kimchi is a traditional Korean food manufactured by fermenting vegetables with probiotic lactic acid bacteria (LAB). Many bacteria are involved in the fermentation of kimchi, but LAB become dominant while the putrefactive bacteria are suppressed during salting of baechu cabbage and the fermentation. The addition of ot...
journal_title:Journal of medicinal food
pub_type: 杂志文章,评审
doi:10.1089/jmf.2013.3083
更新日期:2014-01-01 00:00:00
abstract::The protective effect of beef and pig collagen hydrolysates and their fractions were tested as anti-ulcerogenic agents in rats (weighing 250-350 g) against ulcerative lesions caused by ethanol. Beef and pig collagen hydrolysates were fractionated by ultrafiltration into different molecular weight fractions. The protoc...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2006.262
更新日期:2007-03-01 00:00:00
abstract::The aim of the present study was to investigate the antihyperglycemic and protective potential of crocin, a pharmacologically active constituent of Crocus sativus L., in streptozotocin-induced diabetic rats. Rats were administered crocin intraperitoneally at doses of 15, 30, and 60 mg/kg of body weight for 6 weeks. Th...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2012.2407
更新日期:2013-03-01 00:00:00
abstract::Overwhelming evidence indicates that consumption of fruits and vegetables with antioxidant properties correlates with reduced risk for cancers, including leukemia. Carrots contain beneficial agents, such as β-carotene and polyacetylenes, which could be effective in the treatment of leukemia. This study investigated th...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2010.0284
更新日期:2011-11-01 00:00:00
abstract::This is the first report about the modifying antibiotic activity of Eugenia uniflora L. and Eugenia jambolanum L. In this study the ethanol extract of E. uniflora and E. jambolanum was tested for their antimicrobial activity against strains of Escherichia coli. The growth of the two strains of E. coli bacteria tested ...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2009.0158
更新日期:2010-08-01 00:00:00
abstract::ABSTRACT Recent epidemiological studies have indicated that intake of grapes and other food products such as red wine derived from grapes may lower incidence of cancer and coronary heart diseases. Grapes and grape extracts, in addition to the traditional nutrients such as sugars and vitamins, are also rich sources of ...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2000.3.15
更新日期:2000-04-01 00:00:00
abstract::Premature ejaculation (PE) is one of the foremost sex-related health problems among men. The global occurrence ranges from 20% to 30%, according to various studies. PE has a great impact on the men's quality of life, with deleterious effects such as embarrassment, frustration, and feeling of incompetence. Considering ...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2019.4661
更新日期:2020-09-01 00:00:00
abstract::3,3'-diindolylmethane is a major in vivo metabolite of indole-3-carbinol, a bioactive compound found in cruciferous vegetables. Although 3,3'-diindolylmethane has been implicated to possess antitumorigenic and anti-inflammatory properties, the effect of 3,3'-diindolylmethane on adipogenesis has not been explored previ...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2016.0165
更新日期:2017-07-01 00:00:00
abstract::The extract enriched in total oligomer flavonoids (TOF), and the aqueous, methanol, and ethyl acetate extracts of Acacia salicina were investigated for their polyphenolic compound content, antioxidative activity in the nitro blue tetrazolium/riboflavin assay system, antibacterial activity against Gram-positive and Gra...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2008.0120
更新日期:2009-06-01 00:00:00
abstract::Esophageal cancer (EC) is commonly diagnosed in South Africa (SA), with high incidences occurring in SA's black population. Moringa oleifera (MO), a multipurpose tree, is used traditionally for its nutritional and medicinal properties. It has been used for the treatment of a variety of ailments, including cancer. We i...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2015.0113
更新日期:2016-04-01 00:00:00
abstract::Different polysaccharides were isolated from the leaves of Aloe arborescens using the gradient power of hydrogen followed by antitumor and immunomodulatory assay. The total polysaccharide content of different fractions, water-soluble polysaccharide (WAP), acid-soluble polysaccharide (ACP), and alkaline-soluble polysac...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2016.0148
更新日期:2017-05-01 00:00:00
abstract::Previously, we reported that bamboo culms possess a stronger antioxidative capacity than bamboo leaves in vitro. In this study, we investigated whether bamboo culm extract (BCE) supplementation ameliorates oxidative stress and hepatic nuclear factor kappaB (NF kappa B) activation in C57BL/6 mice fed an atherogenic die...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2007.009
更新日期:2008-03-01 00:00:00
abstract::Propolis was included in the Argentine Food Code as a functional food. The chemical parameters and antioxidant properties of propolis samples from the same colonies of Apis mellifera in San Juan (Cuyo region, Western Argentine) were compared every month for 1 year using two collection methods. Chemical parameters were...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2008.0286
更新日期:2009-12-01 00:00:00
abstract::Allium cepa (Family Liliaceae) is a reputed Indian medicinal herb that is prescribed as an effective remedy for several ailments in the Ayurvedic system of medicine. The aim of this study was to evaluate its efficacy against various events responsible for Type I allergic reactions. A herbal fraction (ALC-02) from A. c...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2007.0642
更新日期:2009-04-01 00:00:00
abstract::We investigated the effect of kaikasaponin III (KS-III) on Phase I and II enzymes and tissue factor (TF) activity to elucidate the pharmacological actions of this immunosuppressive saponin in the diabetic rat. This compound was obtained from the flower of Pueraria thunbergiana (Leguminosae) by chromatographic isolatio...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/109662004322984671
更新日期:2004-04-01 00:00:00
abstract::The aim of the present study was to investigate the protective role of royal jelly (RJ) and green tea (GT) extracts on cisplatin (cDDP)-induced nephrotoxicity in adult albino mice. Albino mice were randomly divided into six groups: Group I (control) received a single intraperitoneal injection of isotonic saline (0.02 ...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2009.0036
更新日期:2009-10-01 00:00:00
abstract::Impaired fasting blood glucose is one of the landmark signs of metabolic syndrome, together with hyperinsulinemia, dyslipidemia, hypertension, and a chronic proinflammatory, pro-oxidative, and prothrombotic environment. This study investigates the effect of wild blueberry (WB) consumption on blood glucose levels and o...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2014.0065
更新日期:2015-06-01 00:00:00
abstract::Extracts of Cissus quadrangularis L. were tested for antioxidant activity by beta-carotene linoleic acid model and also by 1,1-diphenyl-2-picrylhydrazyl model. The ethyl acetate fraction of both fresh and dry stem extracts at a concentration of 100 ppm showed 64.8% antioxidant activity in the beta-carotene linoleic ac...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/109662003322233495
更新日期:2003-07-01 00:00:00
abstract::Cytokine-induced cell death is recognized as a major cause of progressive β-cell loss. Tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), and interferon γ (IFN-γ) in combination trigger a series of events that lead to β-cell death. In the past few decades, the use of myricetin as an anti-inflammatory and cytopro...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2011.2033
更新日期:2012-08-01 00:00:00
abstract::Abnormal expression of pro-inflammatory mediators such as cell adhesion molecules and cytokines has been implicated in various inflammatory skin diseases, including atopic dermatitis. In this study, we investigated the anti-inflammatory activity of Aronia melanocarpa concentrate (AC) and its action mechanisms using in...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2015.3624
更新日期:2016-07-01 00:00:00
abstract::Worldwide prevalence of noncommunicable chronic degenerative diseases is among the main causes of death worldwide. The consumption of some foods such as nuts and seeds may be beneficial in preventing these diseases. Dipteryx alata Vogel (DA), known popularly as Baru, belongs to the family Fabaceae and is a native frui...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2017.0052
更新日期:2017-11-01 00:00:00
abstract::Glucomannan-enriched squid surimi improves cholesterolemia and liver antioxidant status. The effect of squid surimi enriched with glucomannan or glucomannan plus spirulina on liver and heart structures and cell damage markers was tested in fa/fa rats fed highly saturated-hyper-energetic diets. Animals were fed 70% AIN...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2016.0157
更新日期:2017-06-01 00:00:00
abstract::Vegetables are considered to be the most affordable and sustainable sources of several micronutrients that are essential for physical and mental development, immune system functioning, and various metabolic processes in humans. However, their effectiveness as dietary sources of minerals is influenced by mineral-minera...
journal_title:Journal of medicinal food
pub_type: 杂志文章
doi:10.1089/jmf.2006.252
更新日期:2007-09-01 00:00:00