当前位置： SCI文献检索 > PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY期刊下所有文献 > Reduced frequency of T lymphocytes expressing CTLA-4 in frontotemporal dementia compared to Alzheimer's disease.

Reduced frequency of T lymphocytes expressing CTLA-4 in frontotemporal dementia compared to Alzheimer's disease.

Abstract：

:Studies suggest that inflammation is involved in the neurodegenerative cascade of dementias. Immunological mechanisms may be part of the pathophysiological process in frontotemporal dementia (FTD), but up till now only vague evidence of such mechanisms has been presented. The B7- CD28/CTLA-4 pathway is an important immunological signaling pathway involved in modulation of T cell activation. The aim of this study was to compare the expression of molecules associated with co-stimulatory signaling in peripheral blood mononuclear cells (PBMC) of FTD to Alzheimer disease (AD) and control groups. Our results confirm the previous demonstrated increased expression of CD80 in CD14+ Alzheimer patients T cells but show, for the first time, a reduction in the expression of CTLA-4 in CD4+ FTD cells. As CTLA-4 is the most potent negative regulators of T-cell activation we speculated that peripheral T lymphocytes in FTD are more activated and this could be involved in the neurodegeneration observed in this dementia.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Santos RR,Torres KC,Lima GS,Fiamoncini CM,Mapa FC,Pereira PA,Rezende VB,Martins LC,Bicalho MA,Moraes EN,Reis HJ,Teixeira AL,Romano-Silva MA

doi

10.1016/j.pnpbp.2013.06.019

subject

Has Abstract

pub_date

2014-01-03 00:00:00

pages

1-5

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(13)00131-0

journal_volume

48

pub_type

杂志文章

相关文献

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY文献大全
  • Targeting the α7 nicotinic acetylcholine receptor to prevent progressive dementia and improve cognition in adults with Down's syndrome.

    abstract：:As persons with Down's syndrome (DS) age into the third decade and beyond, they develop Alzheimer's disease (AD)-like histopathological changes in brain and may manifest progressive worsening of adaptive functions. Increasingly, persons with DS have near-normal to normal life spans; thus, it has become a therapeutic i...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2014.05.011

    authors： Deutsch SI,Burket JA,Benson AD

    更新日期：2014-10-03 00:00:00

  • Structural neurobiological correlates of Mayer-Salovery-Caruso Emotional Intelligence Test performance in early course schizophrenia.

    abstract：OBJECTIVE:The Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT) is a key measure of social cognition in schizophrenia that has good psychometric properties and is recommended by the MATRICS committee. As a way to further investigate the validity of the MSCEIT, this study sought to examine the neurobiological co...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2012.09.013

    authors： Wojtalik JA,Eack SM,Keshavan MS

    更新日期：2013-01-10 00:00:00

  • Amphetamine and other pharmacological agents in human and animal studies of recovery from stroke.

    abstract：:Neuromodulation with pharmacological agents, including drugs of abuse such as amphetamine, when paired with behavioral experience, has been shown to positively modify outcomes in animal models of stroke. A number of clinical studies have tested the efficacy of a variety of drugs to enhance recovery of language deficit...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2015.04.002

    authors： Walker-Batson D,Mehta J,Smith P,Johnson M

    更新日期：2016-01-04 00:00:00

  • Recent advances of induced pluripotent stem cells application in neurodegenerative diseases.

    abstract：:Stem cell is defined by its ability to self-renewal and generates differentiated functional cell types, which are derived from the embryo and various sources of postnatal animal. These cells can be divided according to their potential development into totipotent, unipotent, multipotent andpluripotent. Pluripotent is c...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2019.109674

    authors： Amin N,Tan X,Ren Q,Zhu N,Botchway BOA,Hu Z,Fang M

    更新日期：2019-12-20 00:00:00

  • Tryptophan availability, 5HT synthesis and 5HT function.

    abstract：:1. Tryptophan increases 5HT synthesis, but the extent to which it increases 5HT release and therefore 5HT function is unclear. 2. The possibility that increased 5HT levels will lead to increased 5HT release is enhanced when 5HT neurons are firing at a higher rate. The rate of firing of 5HT neurons is increased as the ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/0278-5846(89)90126-7

    authors： Young SN,Teff KL

    更新日期：1989-01-01 00:00:00

  • Behavioral and EEG responses to alcohol in nonalcoholic men with a family history of alcoholism.

    abstract：:1. Behavioral and EEG responses were examined in nonalcoholic males with (FH+) and without (FH-) a family history of alcoholism following the consumption of a placebo and real beer. 2. FH+ subjects were less confident of being able to resist another drink following consumption of the placebo and reported higher taste ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/0278-5846(88)90083-8

    authors： Kaplan RF,Hesselbrock VM,O'Connor S,DePalma N

    更新日期：1988-01-01 00:00:00

  • Beta-endorphin fragments (DT gamma E and DE gamma E) reduce opiate withdrawal in guinea pig ileum.

    abstract：:The effect exerted by two beta-endorphin fragments (DTgammaE and DEgammaE) was investigated on the acute opioid dependence induced by mu, kappa and delta receptor agonists in vitro. After a 4-min in vitro exposure to morphine (less selective mu agonist), DAGO (highly selective mu agonist), U50-488H (highly selective k...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(01)00274-3

    authors： Capasso A,Loizzo A

    更新日期：2002-02-01 00:00:00

  • The dopamine and serotonin systems during aging in human and rodent brain. A brief review.

    abstract：:During nonpathological aging, quantitative changes occur in the pre- and post-synaptic elements of both the dopamine and serotonin systems. The level of dopamine in the human striatum declines up to 50% with age, while smaller and more variable changes are found in rodent brain (0-30%). Postsynaptically, the density o...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(87)90053-4

    authors： Morgan DG

    更新日期：1987-01-01 00:00:00

  • GABA and endorphin mechanisms in relation to the effects of benzodiazepines on feeding and drinking.

    abstract：:Behavioural actions of benzodiazepines have a number of significant characteristics. Anxiolytic effects are demonstrable both clinically and experimentally; in addition, there is excellent evidence for a reinforcing effect of these compounds, and a direct involvement in ingestional responses. This review focusses on t...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(83)90016-7

    authors： Cooper SJ

    更新日期：1983-01-01 00:00:00

  • Regulation of beta-amyloid precursor protein and inositol 1,4,5-trisphosphate receptor gene expression during differentiation of a human neuronal cell line.

    abstract：:Retinoic acid-induced differentiation of SH-SY5Y human neuroblastoma cells results in the development of extensive neurite processes as well as changes in cell body morphology toward a neuronal phenotype. The authors have examined concurrent regulation of beta-amyloid precursor protein (APP) and inositol 1,4,5-trispho...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/S0278-5846(02)00352-4

    authors： Murray JN,Igwe OJ

    更新日期：2003-05-01 00:00:00

  • Meta regression: Relationship between antipsychotic receptor binding profiles and side-effects.

    abstract：:Our objective was to examine the association between antipsychotic receptor binding profiles and the magnitude of common side-effects. We used regression analysis to examine the association between the receptor binding affinities of antipsychotic agents (log Ki) and degree of specific antipsychotic side-effects. Data ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2018.01.023

    authors： Olten B,Bloch MH

    更新日期：2018-06-08 00:00:00

  • The effect of corticosterone in rats submitted to the elevated plus-maze and to to pentylenetetrazol-induced convulsions.

    abstract：:1. In order to examine the effects of corticosterone in the anxiety response, the effect of acute, subchronic and chronic corticosterone (CORT) administration were studied using two animal models to study anxiolytic effects of drugs: the elevated plus-maze and the blockade of pentylenetetrazol (PTZ)-induced clonic con...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(94)90097-3

    authors： Andreatini R,Leite JR

    更新日期：1994-12-01 00:00:00

  • Use of chromosomally mapped and identified mouse brain proteins for behavioral genetic analysis of alcoholism.

    abstract：:A logical first place to look in order to identify loci determining behavioral differences between inbred and certain outbred strains of mice is among the proteins expressed in brain. Fourteen mouse brain proteins have been demonstrated to be genetically variant, four of these have been chromosomally mapped and an add...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(86)90072-2

    authors： Goldman D,Crabbe J

    更新日期：1986-01-01 00:00:00

  • Birth months and vulnerability to juvenile delinquency.

    abstract：BACKGROUND:Birth months have been shown to affect susceptibility to schizophrenia and other mental disorders, thus this factor could also affect predisposition to delinquency through biological effects on brain development and personality and/or through relative age effects at school. This study aimed to examine the re...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2007.07.003

    authors： Ohtani T,Sasaki T,Kadomoto I,Kato N,Yoshinaga C

    更新日期：2008-01-01 00:00:00

  • Early-life stress impairs developmental programming in Cadherin 13 (CDH13)-deficient mice.

    abstract：OBJECTIVE:Cadherin-13 (CDH13), a member of the calcium-dependent cell adhesion molecule family, has been linked to neurodevelopmental disorders, including autism spectrum (ASD) and attention-deficit/hyperactivity (ADHD) disorders, but also to depression. In the adult brain, CDH13 expression is restricted e.g. to the pr...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2018.08.010

    authors： Kiser DP,Popp S,Schmitt-Böhrer AG,Strekalova T,van den Hove DL,Lesch KP,Rivero O

    更新日期：2019-03-08 00:00:00

  • Effects of topiramate in patients with cerebellar tremor.

    abstract：PURPOSE:To evaluate the safety and potential beneficial effect of topiramate (TPM) as monotherapy or adjunctive therapy to carbamazepine (CBZ) in patients with cerebellar tremor. METHODS:Nine patients with cerebellar tremor participated a 4-week, open-label, prospective-controlled trial. TPM was given as monotherapy (...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/S0278-5846(03)00170-2

    authors： Sechi G,Agnetti V,Sulas FM,Sau G,Corda D,Pitzolu MG,Rosati G

    更新日期：2003-09-01 00:00:00

  • Preclinical and clinical studies with cysteamine and pantethine related to the central nervous system.

    abstract：:1. Cysteamine is formed by degradation of coenzyme A (CoA) and causes somatostatin (SS), prolactin and noradrenaline depletion in the brain and peripheral tissues. 2. Cysteamine influences several behavioral processes, like active and passive avoidance behavior, open-field activity, kindled seizures, pain perception a...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/0278-5846(90)90072-o

    authors： Vécsei L,Widerlöv E

    更新日期：1990-01-01 00:00:00

  • International regulation of benzodiazepines.

    abstract：:1. The UN Convention 1971 on Psychotic substances requires the World Health Organization to recommend psychotropic substances for international control. 2. This convention is based on evaluating the benefit and risk ratio, in particular on the public health and social problems associated with its use. 3. The UN Commis...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/0278-5846(92)90003-w

    authors： Khan I

    更新日期：1992-01-01 00:00:00

  • Effects of apomorphine and clozapine on conditioned freezing and latent inhibition.

    abstract：:Consistent evidence has shown that learning may be produced in paradigms using electrical stimulation of the inferior colliculus as unconditioned stimulus (US). Much evidence has also been provided for the involvement of dopamine in the setting up of adaptive responses to aversive states generated at this mesencephali...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/S0278-5846(03)00153-2

    authors： Masson S,Avanzi V,Troncoso AC,Brandão ML

    更新日期：2003-09-01 00:00:00

  • Sustained attention deficits in manic and euthymic patients with bipolar disorder.

    abstract：:Sustained attention deficits are proposed to be both state and trait indicators of bipolar disorder. The nature of these deficits and their association with medication and symptoms is not clear yet. The aim of this study was to investigate the impairments in various components of sustained attention task in euthymic a...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2006.04.016

    authors： Bora E,Vahip S,Akdeniz F

    更新日期：2006-08-30 00:00:00

  • Consequences of monoamine oxidase inhibition: increased vesicular accumulation of dopamine and norepinephrine and increased metabolism by catechol-O-methyltransferase and phenolsulfotransferase.

    abstract：:1. Male Sprague-Dawley rats were injected with saline, L-Dopa or pargyline. 2. Synaptic vesicles were prepared from whole brain homogenates. Catecholamines and their metabolites in brain tissues and in synaptic vesicles were measured by high performance liquid chromatography with electrochemical detection. 3. L-Dopa a...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(89)90147-4

    authors： Buu NT,Lussier C

    更新日期：1989-01-01 00:00:00

  • Potential of cystamine and cysteamine in the treatment of neurodegenerative diseases.

    abstract：:Neurodegenerative disorders are a subset of disabling pathologies characterized, in part, by a progressive and specific loss of certain brain cell populations. Current therapeutic approaches for the treatment of these disorders are mainly designed towards symptom management and do not manifestly block their typified n...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2010.11.023

    authors： Gibrat C,Cicchetti F

    更新日期：2011-03-30 00:00:00

  • A review of epidemiological evidence for general anesthesia as a risk factor for Alzheimer's disease.

    abstract：:Exposure to surgery and general anesthesia (GA) has been hypothesized to be a potential risk factor for the development of Alzheimer's disease (AD). Some basic science research studies have demonstrated AD pathology in animals following exposure to inhalational anesthetics. However, controversy exists as to whether GA...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2012.06.022

    authors： Seitz DP,Reimer CL,Siddiqui N

    更新日期：2013-12-02 00:00:00

  • Effect of ACEA--a selective cannabinoid CB1 receptor agonist on the protective action of different antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model.

    abstract：:Endogenous cannabinoid ligands and cannabinoid CB1 receptor agonists have been shown to exert anticonvulsant effects in various experimental models of epilepsy. The purpose of this study was to determine the effects of arachidonyl-2'-chloroethylamide (ACEA-a highly selective cannabinoid CB1 receptor agonist) on the pr...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2012.07.001

    authors： Andres-Mach M,Zolkowska D,Barcicka-Klosowska B,Haratym-Maj A,Florek-Luszczki M,Luszczki JJ

    更新日期：2012-12-03 00:00:00

  • Modafinil as a treatment for Attention-Deficit/Hyperactivity Disorder in children and adolescents: a double blind, randomized clinical trial.

    abstract：:Attention-Deficit/Hyperactivity Disorder (ADHD) is the most prevalent psychiatric disorder currently afflicting children and is among the most common chronic conditions affecting school-age children. Modafinil is structurally different from the psychostimulants that are typically used to treat ADHD and has been report...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.pnpbp.2007.07.025

    authors： Amiri S,Mohammadi MR,Mohammadi M,Nouroozinejad GH,Kahbazi M,Akhondzadeh S

    更新日期：2008-01-01 00:00:00

  • Alcoholic organic brain disease: nosology and pathophysiologic mechanisms.

    abstract：:Study of alcoholic chronic organic brain syndrome may have applicability to the large population of alcoholics with less severe cerebral dysfunction. Brain impairment in alcoholics may be conceptualized as two clinically and neuropathologically distinguishable organic brain syndromes: alcohol amnestic disorder or Kors...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/0278-5846(86)90069-2

    authors： Martin PR,Adinoff B,Weingartner H,Mukherjee AB,Eckardt MJ

    更新日期：1986-01-01 00:00:00

  • 5-HT1A receptor responsivity in anxiety disorders and depression.

    abstract：:1. Azapirones, selective partial agonists at the 5-HT1A receptor subtype, induce hypothermia and corticotropin (ACTH)/cortisol release as specific functional correlates of central 5-HT1A receptor activation. 2. Compared to controls, hypothermic and ACTH/cortisol responses to the azapirone ipsapirone are attenuated in ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/0278-5846(91)90001-h

    authors： Lesch KP

    更新日期：1991-01-01 00:00:00

  • Can we predict treatment response in children with ADHD to a vitamin-mineral supplement? An investigation into pre-treatment nutrient serum levels, MTHFR status, clinical correlates and demographic variables.

    abstract：BACKGROUND:Intent-to-treat analyses from a randomized controlled trial showed significant between-group differences favouring micronutrient treatment on the Clinical Global Impression-Improvement, but no group differences on clinician, parent and teacher ratings of overall ADHD symptoms. There was an advantage of micro...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.pnpbp.2018.09.007

    authors： Rucklidge JJ,Eggleston MJF,Darling KA,Stevens AJ,Kennedy MA,Frampton CM

    更新日期：2019-03-08 00:00:00

  • Amisulpride: limbic specificity and the mechanism of antipsychotic atypicality.

    abstract：:Amisulpride clearly has the clinical profile of an atypical antipsychotic, characterised in particular by its lower propensity to induce extrapyramidal side effects as well as its greater efficacy in treating negative symptoms compared with classical neuroleptics. In addition to the clinical advantages over classical ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2003.09.006

    authors： Möller HJ

    更新日期：2003-10-01 00:00:00

  • Schizophrenia and gut-flora related epigenetic factors.

    abstract：BACKGROUND:Schizophrenia (SZ) is a complex psychiatric disorder and the exact mechanisms that underpin SZ remain poorly understood despite decades of research. Genetic, epigenetic, and environmental factors are all considered to play a role. The importance of gut flora and its influence on the central nervous system ha...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2018.11.005

    authors： Zhuo C,Yao Y,Xu Y,Liu C,Chen M,Ji F,Li J,Tian H,Jiang D,Lin C,Chen C

    更新日期：2019-03-02 00:00:00