Tetany in a child with AIDS receiving intravenous tobramycin.

Abstract:

:Aminoglycosides have been reported to cause tetany by inducing renal wasting of magnesium and secondary hypocalcemia. A 9-year-old girl with AIDS was brought to the emergency department because of tetany. She had just finished a 3-week course of intravenous tobramycin for bronchiectasis and had an elevated serum tobramycin trough level 1 week before the onset of tetany. Hypomagnesemia, hypokalemia, and hypocalcemia had developed. The urine revealed inappropriately high levels of magnesium and potassium despite critically low serum levels, with an appropriately low urine calcium level. This pattern is suggestive of renal toxicity due to tobramycin. Over the next several months, she continued to require supplemental calcium, magnesium, potassium, and phosphorus. She also had nephrotic range proteinuria. Aminoglycoside renal mineral wasting has not previously been described in a child.

journal_name

South Med J

journal_title

Southern medical journal

authors

Slayton W,Anstine D,Lakhdir F,Sleasman J,Neiberger R

doi

10.1097/00007611-199611000-00019

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

1108-10

issue

11

eissn

0038-4348

issn

1541-8243

journal_volume

89

pub_type

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