Abstract:
:Amiodarone, a benzofuran derivative, has proven useful in the control of serious cardiac arrhythmias. We reviewed the English language medical literature to characterize clinical, radiographic, scintigraphic, pathologic, diagnostic, and prognostic data concerning amiodarone pulmonary toxicity. Our review showed that features consistent with amiodarone pulmonary toxicity include exertional dyspnea, fever, and high sedimentation rates, usually in patients taking larger maintenance doses. Positive findings on gallium scan, foamy alveolar macrophages on lung biopsy or bronchoalveolar lavage, and resolution of abnormal chest roentgenogram upon withdrawal of amiodarone and/or institution of corticosteroid therapy support a diagnosis of amiodarone pulmonary toxicity. Conversely, maintenance doses of 400 mg or less daily, normal lung diffusing capacity and bronchoalveolar lavage or lung biopsy specimens without foamy alveolar macrophages are features that make amiodarone pulmonary toxicity unlikely. Amiodarone pulmonary toxicity should be considered in any patient who has new or clinical worsening of respiratory symptoms and/or abnormalities on chest roentgenogram. Congestive heart failure is often present in these patients and must be excluded before a diagnosis of amiodarone pulmonary toxicity can be considered. Amiodarone pulmonary toxicity also needs to be distinguished from pulmonary infection. Therefore, amiodarone pulmonary toxicity remains a clinical diagnosis relying upon a composite of clinical, radiographic, and histopathologic findings.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Fraire AE,Guntupalli KK,Greenberg SD,Cartwright J Jr,Chasen MHsubject
Has Abstractpub_date
1993-01-01 00:00:00pages
67-77issue
1eissn
0038-4348issn
1541-8243journal_volume
86pub_type
杂志文章,评审abstract::Pseudoepitheliomatous hyperplasia (PEH) arises in areas of chronic inflammation and can be mistaken for squamous cell carcinoma, leading to unnecessary removal of more tissue. We present a study of 21 patients having delayed reconstruction of defects left by Mohs micrographic surgery (MMS) to remove facial skin cancer...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199504000-00014
更新日期:1995-04-01 00:00:00
abstract::A woman with diabetes mellitus and coronary artery disease developed pneumonia and bacteremia from Branhamella catarrhalis. This is only the fifth reported case of pneumonia with bacteremia due to this organism, which was previously considered normal upper airway flora. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198910000-00035
更新日期:1989-10-01 00:00:00
abstract:OBJECTIVES:Airway failures are the second leading cause of potentially preventable death on the battlefield. Improvements in airway management depend on identifying current challenges. We sought to build on previously reported data on prehospital, combat airway management. METHODS:We used a series of emergency departm...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000906
更新日期:2018-12-01 00:00:00
abstract::Although alpha 1-antitrypsin deficiency has been associated with obstructive lung disease in individuals possessing a homozygous phenotype (PiZZ), this association has not been as clearly documented in heterozygous individuals (PiMZ, PiMS, and PiSZ phenotypes). Information regarding the heterozygous adolescent populat...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199610000-00018
更新日期:1996-10-01 00:00:00
abstract::We studied the effects of intraosseous (IO) infusion of a standard fluid bolus and resuscitative drugs on long-term bone growth and epiphyseal closure in the "pediatric" swine model. Eighteen weanling pigs were randomly assigned to six groups as follows: three animals received two normal saline boluses, 20 mL/kg IO ov...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199208000-00007
更新日期:1992-08-01 00:00:00
abstract::Two cases are presented in which an association between unilateral renal agenesis and multiple skeletal abnormalities is found. The pathologic agents responsible for the URA act similarily on other organ systems, including the skeleton. The skeletal abnormality can be diagnosed easily and promptly and may be an indica...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197601000-00029
更新日期:1976-01-01 00:00:00
abstract:OBJECTIVES:Although we know much about work-related physician burnout and the subsequent negative effects, we do not fully understand work-related physician wellness. Likewise, the relation of wellness and burnout to physician happiness is unclear. The purpose of this study was to examine how physician burnout and well...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000437
更新日期:2016-04-01 00:00:00
abstract::A 76-year-old man with chronic obstructive pulmonary disease who developed P multocida pneumonia and bacteremia has been described. The infection was treated with antibiotics, and the patient recovered. Pasteurella multocida is known to infect many species of animals. The instances of human infection due to this organ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197709000-00035
更新日期:1977-09-01 00:00:00
abstract::Maffucci's syndrome in a 17-year-old girl is reported. Since the entity was first described in 1881 by Maffucci, 105 additional cases have been recorded. Several series have reported a small but significant percentage of cases (up to 18%) with malignant change. Our case, although not particularly unique in comparison ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197804000-00033
更新日期:1978-04-01 00:00:00
abstract:BACKGROUND:Postpneumonectomy electrocardiographic (ECG) changes have not been well-defined. METHODS:We reviewed the clinical data and the preoperative and postpneumonectomy ECGs of 15 patients who had pneumonectomy. RESULTS:All postpneumonectomy ECGs showed a higher heart rate and two (13%) showed diffuse ST elevatio...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2000-10-01 00:00:00
abstract::We have described a 38-year-old white American woman who had a 7-year history of pain in the left anterior chest, neck, right wrist, and buttocks. The pain fluctuated in severity and appeared to coincide with worsening of her skin condition, palmoplantar pustulosis (PPP). She manifested the typical skeletal features o...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199304000-00021
更新日期:1993-04-01 00:00:00
abstract::Sucralfate is an unabsorbed antiulcer drug that binds to gastrointestinal tissue and protects it from acid and pepsin. Twenty-two arthritic patients taking nonsteroidal anti-inflammatory drugs (NSAIDs) were given sucralfate concomitantly for two weeks in an attempt to lessen gastrointestinal side effects. Changes from...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198508000-00011
更新日期:1985-08-01 00:00:00
abstract::Overall physical fitness has become increasingly popular in the 1990s, especially in the geriatric community. More runners, bikers, swimmers, and aerobic advocates over the age of 55 are requiring medical attention for foot complaints, as the feet are a necessary tool for almost any athletic activity. This paper discu...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract::The modern, comprehensive care of patients with hemophilia requires an awareness that complications other than those caused by acute hemorrhage can occur. The use of newer, more potent plasma concentrates has been accompanied by an increased incidence of liver disease in transfusion-requiring hemophiliacs. The progres...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-198002000-00011
更新日期:1980-02-01 00:00:00
abstract::Meropenem is a new carbapenem antibiotic shown to resist degradation by renal dehydropeptidase I. In a multicenter, open-label, prospective trial, we compared the efficacy and safety of meropenem with imipenem/cilastatin in patients with skin and soft tissue infections. Patients received either 500 mg of meropenem eve...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/00007611-199504000-00003
更新日期:1995-04-01 00:00:00
abstract::Since April 1975, 292 patients have had gastric operations for morbid obesity: gastric bypass with Roux-en-Y gastrojejunostomy (RY), 105 patients; gastric bypass with loop gastrojejunostomy (loop), 69 patients; greater curvature gastroplasty, 40 patients; and gastric partition with gastrogastrostomy, 78 patients. Foll...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198211000-00005
更新日期:1982-11-01 00:00:00
abstract:OBJECTIVES:Studies have shown that the overutilization of laboratory tests ("labs") for hospitalized patients is common and can cause adverse health outcomes. Our objective was to compare the ordering tendencies for routine complete blood counts (CBC) and chemistry panels by internal medicine residents and hospitalists...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000592
更新日期:2017-01-01 00:00:00
abstract::Clotrimazole is a new antifungal agent which is effective topically in dermatophytosis, cutaneous candidiasis, and tinea vesicolor. The authors performed a controlled double-blind clinical trial comparing topical clotrimazole with its vehicle in the treatment of 66 patients with dermatophytic infections of the skin of...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章
doi:10.1097/00007611-197701000-00021
更新日期:1977-01-01 00:00:00
abstract:OBJECTIVES:To explore temporal trends and geographic variations in mortality from prescription opioids from 1999 to 2016. METHODS:Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research Multiple Cause of Death files were used to calculate age-adjusted rates and 95% confidence int...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000001074
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Surveys in recent years show that office emergencies are likely to occur in pediatric offices and that most offices are not equipped to deal with these situations. METHODS:To determine the pediatrician's preparedness to manage emergencies, we surveyed a randomly selected sample of 240 office-based pediatric...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199808000-00008
更新日期:1998-08-01 00:00:00
abstract::We studied the prevalence of non-group-A beta-hemolytic streptococci (NGAS) in the pharyngeal cultures of symptomatic and asymptomatic children. Throat cultures were obtained by house officers in the Emergency Department at Children's Hospital of Pittsburgh to aid in the evaluation of children with symptoms or signs o...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-198803000-00011
更新日期:1988-03-01 00:00:00
abstract::We report the case of a term newborn with vein of Galen aneurysm. No antenatal diagnosis was done. The infant was admitted secondary to cardiac failure, with cardiomegaly and pulmonary hypertension. Physical examination was remarkable for acrocyanosis, microcephaly, cranial bruit, bilateral neck swelling, coarse breat...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-200405000-00020
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVES:Gas exchange measurements obtained during submaximal exercise have been shown to provide prognostic and diagnostic information in patients with heart failure (HF) and to differentiate heart versus lung limitations in patients with unexplained dyspnea. The aim of our study was to assess the clinical utility o...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0000000000000066
更新日期:2014-03-01 00:00:00
abstract::Pain is a tax levied on man for the privilege of life upon this planet. Some are taxed lightly and others are taxed heavily, but all are taxed. To relieve this stress, from time immemorial man has taken analgesics. In modern times, if home medication fails, professional consultation is available. The important questio...
journal_title:Southern medical journal
pub_type: 历史文章,杂志文章
doi:
更新日期:1980-12-01 00:00:00
abstract::Obstructive biliary disease in childhood is not common, but should be considered in the differential diagnosis of a child with jaundice, abdominal pain, or an abdominal mass. We have reviewed the experience at Vanderbilt Children's Hospital from 1970 to 1985, during which 87 children 18 years of age or younger with bi...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198611000-00007
更新日期:1986-11-01 00:00:00
abstract::I have reported three case of paraurethral cysts in female neonates. These are uncommon lesions, and urologic evaluation is required to differentiate them from ectopic ureteroceles, urethral diverticula, or paraurethral tumors. Histologic appearance of the cyst epithelium identifies the embryologic origin. The cysts e...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198506000-00035
更新日期:1985-06-01 00:00:00
abstract::A 63 year-old woman who had had mitral valve commissurotomy 12 years earlier was seen because of rheumatic mitral stenosis and left brachial paresis due to cerebral embolism. On clinical evaluation, a diastolic rumble was heard over the mitral area, and the echocardiogram revealed a mass attached to the mitral subvalv...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199910000-00017
更新日期:1999-10-01 00:00:00
abstract::Conventional rate limits for sinus rhythm--100/min as the tachycardia threshold and 60/min as the bradycardia threshold--were established by consensus and never formally examined. Because clinical experience indicated that both figures were too high, we investigated this formally in 500 normal individuals. Results wer...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199607000-00003
更新日期:1996-07-01 00:00:00
abstract::This paper explores the possibility that bed sharing may carry particular risks for children with special healthcare needs (CSHCN). Two cases of CSHCN who may have sustained adverse health effects from bed sharing are described. These two case reports indicate that CSHCN may be particularly susceptible to risks associ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.smj.0000220843.75686.cb
更新日期:2006-09-01 00:00:00
abstract::Coronary heart disease (CHD) is the leading cause of morbidity and mortality in patients more than 65 years old. Within this population, elevated cholesterol levels are prevalent and associated with increased risk of CHD. Despite increasing emphasis on lipid-lowering treatment in the elderly population, questions rema...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:
更新日期:2002-11-01 00:00:00