Abstract:
:We studied the effects of intraosseous (IO) infusion of a standard fluid bolus and resuscitative drugs on long-term bone growth and epiphyseal closure in the "pediatric" swine model. Eighteen weanling pigs were randomly assigned to six groups as follows: three animals received two normal saline boluses, 20 mL/kg IO over 20 minutes; three received sodium bicarbonate, 1 mEq/kg IO; three received a 10% sodium bicarbonate infusion IO at maintenance rate over 1 hour; three received epinephrine 1:10,000, 0.1 mL/kg IO; three received an epinephrine infusion IO at 1 microgram/kg/min for 1 hour; and three received a dopamine infusion IO at 10 micrograms/kg/min for 1 hour. All infusions were given in the left hindleg; the right hindleg was used as a control. Lateral radiographs of the hind extremities were obtained at the beginning of the study and at 1 and 3 months after infusion. Linear radiographic measurements of the infused and control tibias were compared. At 6 months after infusion, the tibias were harvested, measured directly, and radiographed to determine the degree of epiphyseal closure. Analysis of variance for the first 3 months' data yielded a nonsignificant time-by-treatment interaction (P = .84) and a nonsignificant main effect for time (P = .22). Separate analysis of the direct measurements taken at 6 months revealed no difference in growth between experimental and control tibias. In addition, no radiographic difference in epiphyseal closure was noted between the two groups at the conclusion of the study, nor were any structural defects discovered. Intraosseous infusion of fluids and resuscitative drugs does not adversely affect subsequent bone growth and development in the swine model.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Woodall BN,Pender ES,Pollack CV Jr,Miller H,Tubbs RC,Andrew MEdoi
10.1097/00007611-199208000-00007subject
Has Abstractpub_date
1992-08-01 00:00:00pages
820-4issue
8eissn
0038-4348issn
1541-8243journal_volume
85pub_type
杂志文章abstract::Considerable controversy exists with regard to therapeutic efficacy of plasmapheresis in the immune-mediated demyelinating disorders of the peripheral and central nervous system: acute inflammatory polyneuropathy (Guillain-Barré syndrome), chronic inflammatory demyelinating polyneuropathy, and multiple sclerosis. In a...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-198608000-00018
更新日期:1986-08-01 00:00:00
abstract::Two cases are reviewed which presented findings strongly suggesting congenital synostosis between the third metatarsal and third cuneiform bones. Supplementary x-ray films proved these joints to be present and intact. This point, though well known to skeletal radiologists, is worthy of emphasis to nonskeletal radiolog...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::The use of stress echocardiography (SE) in an elderly population was retrospectively evaluated and compared with myocardial perfusion scintigraphy (MPS) in a similar group. Patients > or = 80 years of age were evaluated by treadmill or pharmacologic SE (group 1; n = 65) to determine its predictive value for cardiac ev...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199612000-00007
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND:Cancer of the esophagus remains a highly lethal disease, but new treatment approaches that build onto traditional surgical and radiotherapeutic methods are making an impact on organ preservation while offering hope for improved survival. METHODS:Reviewed here are recent data from trials on the use of new ra...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章,随机对照试验,评审
doi:10.1097/00007611-199911000-00003
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVES:The lack of access to diagnostic imaging in resource-limited settings (RLSs) poses a worldwide problem. Advances in ultrasound (US) imaging technology bridge this gap, particularly when examinations are performed by physicians and integrated into the patient encounter, termed point-of-care ultrasound (POCUS)...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000826
更新日期:2018-07-01 00:00:00
abstract::We retrospectively reviewed medical records and computerized critical care data for 40 consecutive critically ill surgical patients receiving "standard" doses (1.5 to 2.0 mg/kg loading dose and 3 to 5 mg/kg/day) of gentamicin or tobramycin for gram-negative infections. End points measured were serum drug levels and cl...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199701000-00007
更新日期:1997-01-01 00:00:00
abstract::The Pelorus Stereotactic Surgical System is a relatively new, commercially available device that can be used to perform computed tomography (CT)-guided stereotactic brain biopsy. It has been promoted as being a relatively simple and inexpensive system that is more rapid, less cumbersome, and generally easier to use th...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199307000-00008
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVE:To compare mobile health (mHealth) usage by residents of West Virginia with national estimates. METHODS:Pew Research Center data from its Internet and American Life Project were accessed for secondary data analysis. These data, available to the public, are a probability sample of Internet use in the United S...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000879
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVES:Shear wave elastography (SWE) is an emerging technology that assesses hepatic fibrosis. The aim of our study was to determine the diagnostic accuracy of General Electric (GE) Healthcare's LOGIQ E9 SWE in patients with chronic hepatitis C virus using liver biopsy as the reference standard. METHODS:The liver ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000562
更新日期:2016-11-01 00:00:00
abstract::We describe a fatal case of tuberculous peritonitis and review the literature on the diagnostic modalities available to diagnose this entity. We suspect a delayed diagnosis resulted in the death of our patient. Today, the prompt diagnosis of an unknown ascitic process involves laparoscopy. A patient with unknown large...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199904000-00010
更新日期:1999-04-01 00:00:00
abstract:OBJECTIVES:Total annual costs for syncope-related hospitalizations were $2.4 billion in 2000. The aim of this study was to examine the type and number of tests ordered for patients admitted with syncope and whether these tests helped establish the cause. METHODS:We studied the records of 1038 patients coded as "syncop...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000184
更新日期:2014-11-01 00:00:00
abstract::We have described a young man who had acute myocardial infarction after his first use of cocaine. This case demonstrates that potentially lethal myocardial infarctions may be associated with such initial "experimentation" with cocaine even in relatively small doses. Cocaine intoxication should be considered in young p...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198707000-00035
更新日期:1987-07-01 00:00:00
abstract::Two premature infants were infected with HIV via blood transfusions during the neonatal period. Although neither patient had serum antibody to HIV owing to severe hypogammaglobulinemia, HIV infection was confirmed by finding HIV antigen in the sera of both patients. These cases show that HIV infection can produce seve...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198904000-00005
更新日期:1989-04-01 00:00:00
abstract::Several recent cases illustrate the medical-ethical-legal consequences associated with lack of awareness in caring for and treating the dying patient. We question whether solutions advanced by others are feasible or desirable for use in medical education, and suggest looking to the familiar principles of clinical medi...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197904000-00011
更新日期:1979-04-01 00:00:00
abstract::The Chronic Illness Problem Inventory (CIPI) was used to assess level of psychosocial functioning in 89 patients with sickle cell disease. The results indicated that sickle cell patients have significant psychosocial distress in the areas of employment and finances, sleeping and eating, and performance of normal daily...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198806000-00015
更新日期:1988-06-01 00:00:00
abstract::A marked increase in the number of cases of shigellosis was reported in Kentucky in 1988. To examine reasons for this increase, we reviewed the 389 cases of shigellosis reported from 1986 through 1989. Ninety-three percent (285/305) of cases due to known species were due to Shigella sonnei. Sixty-two percent (243/389)...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199107000-00002
更新日期:1991-07-01 00:00:00
abstract::Pregnancy is an unusual occurrence in women with ESRD. We report a successful pregnancy in a patient with ESRD who was receiving hemodialysis; she gave birth to a healthy female infant at 34 weeks' gestational age. We discuss possible physiologic causes of gonadal dysfunction in patients with ESRD. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199102000-00033
更新日期:1991-02-01 00:00:00
abstract::We have described a case of maternal primary aldosteronism in which there is virilization of the female offspring. The most common causes of virilization are considered unlikely on the basis of clinical and laboratory data. The report illustrates the exacerbation of aldosteronism that occurs postpartum and emphasizes ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1983-04-01 00:00:00
abstract::We surveyed 1528 first-year students at the University of Virginia, 1 month after their arrival on campus, who had used alcohol at some time in their lives. Our survey was designed to identify alcohol and cocaine use, and related psychosocial patterns. Men drank more and more often than women. Our data suggest that bo...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199101000-00005
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVES:Insurance status has the potential to play a significant role in an individual's health care by affecting the time of diagnosis and the treatment options used. Our study reviewed insurance status as a determinant of the time of a breast cancer diagnosis as well as the surgical treatment options offered. MET...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000281
更新日期:2015-05-01 00:00:00
abstract::Patent ductus arteriosus (PDA) is a malady usually identified during childhood. Prompt surgical correction provides definitive therapy with long-term survival. When not corrected, PDA leads to significant morbidity and mortality, making it a rare condition in the adult population. We report the case of a 44-year-old m...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:
更新日期:2001-03-01 00:00:00
abstract::Unicompartmental replacement using the Marmor prosthesis was done in 40 knees (37 patients) with medial compartment gonarthrosis. Of the 27 available for follow-up, results were considered excellent in 18 cases and good in seven, while two cases were considered failures. Meticulous removal of osteophytes by intercondy...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197906000-00013
更新日期:1979-06-01 00:00:00
abstract::Rocky Mountain spotted fever is a serious acute systemic illness frequently complicated by cardiac involvement. To evaluate the spectrum of myocardial dysfunction, we obtained M-mode echocardiograms on nine consecutive patients with Rocky Mountain spotted fever within 72 hours of admission. Seven of the nine patients ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198409000-00019
更新日期:1984-09-01 00:00:00
abstract::Cephalosporin antibiotics are the most frequently used agents for surgical prophylaxis. Within this class are considerable pharmacokinetic variations that could have significant implications. We used a computer simulation of cephalosporin serum levels to describe concentrations achieved and maintained intraoperatively...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198508000-00018
更新日期:1985-08-01 00:00:00
abstract::We describe two cases of drug-induced hypertriglyceridemia, one associated with interferon alfa-2b and the other with asparaginase, each of which is mediated through a different mechanism. Hypertriglyceridemia caused by these medications is not listed as an adverse reaction in the Physicians' Desk Reference, one of th...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199909000-00013
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVES:To design and implement a formal otolaryngology inpatient consultation service that improves satisfaction of consulting services, increases educational opportunities, improves the quality of patient care, and ensures sustainability after implementation. METHODS:This was a retrospective cohort study in a lar...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000763
更新日期:2018-02-01 00:00:00
abstract::We investigated psyllium fiber supplementation as a means of enhancing the cholesterol-lowering effect of the phase I American Heart Association diet. Fifty-nine subjects with total serum cholesterol (TC) levels ranging from 5.56 to 10.24 mmol/L (215 to 396 mg/dL) were given a 2-month dietary lead-in followed by 3 mon...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007611-199010000-00005
更新日期:1990-10-01 00:00:00
abstract::Thoracic nerve root dysfunction (TNRD) manifested as abdominal pain is an infrequently reported condition. We present data on six patients who had chronic intermittent thoracoabdominal pain originating in the back. Diabetes and osteoarthritis of the spine were the chief causes of these symptoms. The electromyogram in ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198802000-00014
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND:Despite an effective tetanus vaccine, tetanus continues to claim lives worldwide. The very young and the elderly are at highest risk for the disease. Farmers are at high risk for injury, the leading factor associated with tetanus. METHODS:As part of a larger study of older members of farm households in the ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e31818f6544
更新日期:2009-03-01 00:00:00
abstract::We have presented an unusual case of CJD in which the magnetic resonance images obtained four months before death revealed high signal intensity in the caudate nuclei bilaterally. These findings correspond to severe involvement of this region at autopsy. This radiologic pattern has not generally been included in the d...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1989-09-01 00:00:00