Aminoglycoside levels in critically ill surgical patients: the implications of physiologic criteria of sepsis.

Abstract:

:We retrospectively reviewed medical records and computerized critical care data for 40 consecutive critically ill surgical patients receiving "standard" doses (1.5 to 2.0 mg/kg loading dose and 3 to 5 mg/kg/day) of gentamicin or tobramycin for gram-negative infections. End points measured were serum drug levels and clearance of infection. Therapeutic serum aminoglycoside levels were achieved within 48 hours of therapy by only 7 patients (17.5%). Among the remaining 33 patients, significantly fewer septic than nonseptic patients had clearance of their infection (11% vs 92%). Specific physiologic criteria of sepsis may be used to identify critically ill patients who will most likely benefit from aggressive initial aminoglycoside dosing when these drugs are used to treat gram-negative infections.

journal_name

South Med J

journal_title

Southern medical journal

authors

Cornwell EE 3rd,Belzberg H,Berne TV,Kern JW,Henriques G,Asensio JA,Demetriades D

doi

10.1097/00007611-199701000-00007

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

33-6

issue

1

eissn

0038-4348

issn

1541-8243

journal_volume

90

pub_type

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