Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension.

Abstract:

BACKGROUND:Increasing numbers of the adult population are using alternative or complementary health resources in the treatment of chronic medical conditions. Systemic hypertension affects more than 50 million adults and is one of the most common risk factors for cardiovascular morbidity and mortality. This study evaluates the antihypertensive effectiveness of oral coenzyme Q10 (CoQ), an over-the-counter nutritional supplement, in a cohort of 46 men and 37 women with isolated systolic hypertension. METHODS:We conducted a 12-week randomized, double-blind, placebo-controlled trial with twice daily administration of 60 mg of oral CoQ and determination of plasma CoQ levels before and after the 12 weeks of treatment. RESULTS:The mean reduction in systolic blood pressure of the CoQ-treated group was 17.8 +/- 7.3 mm Hg (mean +/- SEM). None of the patients exhibited orthostatic blood pressure changes. CONCLUSIONS:Our results suggest CoQ may be safely offered to hypertensive patients as an alternative treatment option.

journal_name

South Med J

journal_title

Southern medical journal

authors

Burke BE,Neuenschwander R,Olson RD

doi

10.1097/00007611-200111000-00015

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

1112-7

issue

11

eissn

0038-4348

issn

1541-8243

journal_volume

94

pub_type

临床试验,杂志文章,随机对照试验
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    authors: Benzel EC,Musgrove CC 2nd,Kesterson L

    更新日期:1989-05-01 00:00:00

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    journal_title:Southern medical journal

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    authors: Moellering RC Jr,Kunz LJ,Poitras JW,Cameron M,Mercier BA

    更新日期:1977-10-01 00:00:00

  • Relationship between frequency of sexual intercourse and urinary tract infections in young women.

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    authors: Gordon GM,Cuttic MM

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    journal_title:Southern medical journal

    pub_type: 杂志文章

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  • Evaluation of state-provided postexposure prophylaxis against rabies in Florida.

    abstract:BACKGROUND:One key component of human rabies prevention is the use of postexposure prophylaxis (PEP). No information is routinely available to evaluate the appropriateness of this intervention. METHODS:A survey queried county health departments regarding rabies PEP administered during July through September in 1997 an...

    journal_title:Southern medical journal

    pub_type: 杂志文章

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    authors: Conti L,Wiersma S,Hopkins R

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    更新日期:1983-02-01 00:00:00

  • Severe pulmonary hypertension with patent ductus arteriosus.

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    更新日期:1980-05-01 00:00:00

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    pub_type: 历史文章,杂志文章

    doi:

    authors: Krantz JC Jr,White JM

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    journal_title:Southern medical journal

    pub_type: 杂志文章,评审

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    更新日期:1990-04-01 00:00:00

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    pub_type: 杂志文章

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  • Trimethoprim-sulfamethoxazole in the treatment of gonorrhea: comparison with standard treatment schedules.

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    pub_type: 杂志文章

    doi:10.1097/00007611-197509000-00020

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    更新日期:1975-09-01 00:00:00

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    pub_type: 杂志文章

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  • Placenta increta occurring in a blighted ovum.

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    pub_type: 杂志文章

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    更新日期:1996-05-01 00:00:00