Leukocytosis and hypercalcemia: a rare combination of paraneoplastic features in squamous cell penile cancer.

Abstract:

:Penile cancer is very rare in North America and Europe, as compared with the rest of the world. Squamous cell carcinoma (SCC) accounts for more than 95% of the cancer type. Paraneoplastic syndrome (PNS), a clinical syndrome of nonmetastatic systemic effects that occurs in patients with malignant disease, is often associated with SCC. However, the association of penile SCC with leukocytosis and hypercalcemia is very rare. We report a case of penile SCC involving a change in the patient's mental status along with hypercalcemia and leukocytosis; all three conditions resolved after the tumor was excised. We also discuss the possible factors contributing to hypercalcemia, leukocytosis and change in mental status in SCC. These three conditions and other features of PNS can significantly influence a patient's overall prognosis and, if recognized early, can play an important role in the care plan.

journal_name

South Med J

journal_title

Southern medical journal

authors

Doraiswamy VA,Biboa J,Obafemi A,Goldschmid M

doi

10.1097/SMJ.0b013e3181d7b802

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

474-6

issue

5

eissn

0038-4348

issn

1541-8243

journal_volume

103

pub_type

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