Oxidative stress in diabetic macrovascular disease: does homocysteine play a role?

Abstract:

BACKGROUND:Non-insulin-dependent diabetes mellitus (NIDDM) and hyperhomocysteinemia are both associated with increased lipid peroxidation (oxidative stress). This may contribute to the accelerated vascular disease associated with these conditions. It is not known whether the coexistence of elevated homocysteine levels will stimulate oxidative stress further than that caused by diabetes alone. METHODS:Plasma concentrations of thiobarbituric acid reactive substances (TBARS), an index of lipid peroxidation, were measured in patients with NIDDM who had previously had a methionine load test; some of the patients had hyperhomocysteinemia. RESULTS:Plasma TBARS concentrations were elevated in diabetics with vascular disease. The additional presence of hyperhomocysteinemia was not associated with a further increase in plasma TBARS concentrations. CONCLUSIONS:Lipid peroxidation is increased in patients with diabetes mellitus and macrovascular disease and is not further elevated by the coexistence of elevated homocysteine levels. It is possible that diabetes maximally stimulates oxidative stress and any further acceleration of vascular disease in patients who have coexistent hyperhomocysteinemia is mediated through mechanisms other than lipid peroxidation.

journal_name

South Med J

journal_title

Southern medical journal

authors

Fonseca VA,Stone A,Munshi M,Baliga BS,Aljada A,Thusu K,Fink L,Dandona P

doi

10.1097/00007611-199709000-00008

subject

Has Abstract

pub_date

1997-09-01 00:00:00

pages

903-6

issue

9

eissn

0038-4348

issn

1541-8243

journal_volume

90

pub_type

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