Safety and efficacy of the drug-eluting stent: a double-edged sword?

Abstract:

:Like the introduction of bare metal stents (BMS), that of drug-eluting stents (DES) represented a quantum leap in the interventional cardiology community's ongoing efforts to conquer restenosis. However, recent concerns over late thrombosis (LT) have tempered the initial enthusiasm. Nonetheless, when compared with BMS, the slightly higher DES-LT is counterbalanced by the device's markedly lower incidence of restenosis, resulting in net equivalent rates of death, myocardial infarction, and overall major adverse cardiovascular events. This article summarizes for the noncardiology practitioner the benefits and risks of DES, as well as essentials of postprocedural care of the DES patient. We discuss the pathophysiology of stent thrombosis, pivotal DES trials, and adjunct antiplatelet pharmacology. In December 2006, the Food and Drug Administration convened an expert panel to review these devices. Their recommendations, as well as the joint statement from the American College of Cardiology/American Heart Association/Society of Cardiovascular Angiography and Interventions, are outlined.

journal_name

South Med J

journal_title

Southern medical journal

authors

Chen JP

doi

10.1097/01.smj.0000286752.67205.e0

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

174-8

issue

2

eissn

0038-4348

issn

1541-8243

pii

00007611-200802000-00022

journal_volume

101

pub_type

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