Abstract:
:Endorphins and narcotics have been implicated in the exacerbation of neurologic deficits after stroke. To test the theory that narcotic antagonists might offer an improvement in neurologic sequelae following stroke, we administered various doses of naloxone intraperitoneally to 50 adult gerbils 45 minutes after carotid artery transsection. Low-dose naloxone therapy (1.0 to 2.5 mg/kg) was more effective in preventing death than either control (sterile saline) or high-dose naloxone (10 mg/kg). A naloxone dose of 1.0 or 2.5 mg/kg offered a significant improvement in mortality over both the control and the high-dose therapy (P = .026). It appears that an appropriate dose of naloxone (1.0 to 2.5 mg/kg), given early enough to alter outcome, offers an improved survival in the gerbil stroke model. This finding obviously has significant implications for the use of narcotic antagonists in human beings with stroke.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Benzel EC,Musgrove CC 2nd,Kesterson Ldoi
10.1097/00007611-198905000-00005subject
Has Abstractpub_date
1989-05-01 00:00:00pages
555-7issue
5eissn
0038-4348issn
1541-8243journal_volume
82pub_type
杂志文章abstract::The National Cholesterol Education Program and physician/patient awareness of the risks of hypercholesterolemia have resulted in aggressive screening and treatment of elevated cholesterol levels. The "one size fits all" concept has been used as the criterion for intervention. However, this has been promulgated without...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199310001-00003
更新日期:1993-10-01 00:00:00
abstract::Bleeding is the most serious complication of thrombolytic therapy and limits its usefulness. We have reported a case of epidural hematoma, a rare occurrence after combined therapy with tissue plasminogen activator (TPA) and heparin. We emphasize that in patients treated with thrombolytic agents, any trauma may increas...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1991-05-01 00:00:00
abstract::We present the case of a 59-year-old woman with an International Federation of Gynecology and Obstetrics stage IIIB serous psammocarcinoma. Only 12 cases of this rare ovarian neoplasm have been reported previously. These tumors act like borderline tumors and, therefore, do not usually require chemotherapy or radiation...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199805000-00015
更新日期:1998-05-01 00:00:00
abstract::Acute methemoglobinemia is a medical emergency that can rapidly become fatal. A substantial number of drugs, including topical preparations, can precipitate this condition. I report a rare example of severe, acute methemoglobinemia caused by oropharyngeal anesthesia with topical benzocaine spray for orogastric intubat...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199709000-00018
更新日期:1997-09-01 00:00:00
abstract::The temporary tissue expander can generate an excess of full-thickness skin that can be recruited into an adjacent area of tissue deficiency caused by scar contracture. The creation of a pseudobursa enhances the functional improvement gained by this technique. Now in its developmental stage, tissue expansion carries a...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198604000-00011
更新日期:1986-04-01 00:00:00
abstract::The advantages of topical (as opposed to systemic) therapy for allergic rhinitis include the avoidance of undesirable systemic effects and the concentration of therapeutic effect on the target organ. Successful topical therapy requires establishment of a proper diagnosis, followed by effective delivery of the medicati...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199202000-00008
更新日期:1992-02-01 00:00:00
abstract::We describe a patient with pseudotumor cerebri for which a lumboperitoneal (LP) shunt was placed. After a pseudomeningocele was noted at the lumbar incision site, an LP shunt revision was done, at which time migration of the catheter into the thecal sac was noted. Three months later, radiologic studies revealed crania...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199606000-00019
更新日期:1996-06-01 00:00:00
abstract::Vesicoureteral reflux occurs in approximately 50% of duplex systems that undergo evaluation and most commonly involves the lower renal segment ureter. The therapeutic approach can be tailored for each case after careful evaluation of the anatomic and functional status of each renal unit. If reparative srugery is indic...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197611000-00017
更新日期:1976-11-01 00:00:00
abstract::Ovarian vein thrombophlebitis is often misdiagnosed because of vague symptoms leading to unnecessary surgery, morbidity, and mortality. CT findings in such a case are very useful in making a definite diagnosis of ovarian vein thrombophlebitis. We consider CT the preferred method for evaluating pain in the right lower ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198911000-00022
更新日期:1989-11-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to assess the cardiovascular health status of baby boomers with diabetes mellitus (DM) in comparison to the same-age population with DM 10 years previously. METHODS:The study was conducted in baby boomers with DM using data from the National Health and Nutrition Examination S...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000473
更新日期:2016-06-01 00:00:00
abstract::Forty-four patients with metastatic brain neoplasms received glycerol instead of corticosteroids during periods of brain irradiation. Headache, nausea, and vomiting were controlled in more than 90% of symptomatic patients, while paralysis, confusion, and papilledema improved in 55% to 80%. Patients with minimal or no ...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章
doi:
更新日期:1980-09-01 00:00:00
abstract::We studied 56 patients with primary gastrointestinal lymphoma to determine the manifestations, diagnostic and treatment methods, and patient outcomes. We identified 27 cases of primary gastric lymphoma and 29 cases of lymphoma involving the remainder of the gastrointestinal tract. Initial symptoms were nonspecific and...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198508000-00004
更新日期:1985-08-01 00:00:00
abstract::Treatment of major abdominal vascular injuries is a challenge. Since 1973, 93 patients have been treated at our institution for 147 abdominal vascular injuries. The majority of these injuries (67%) resulted from penetrating trauma in young men between 21 and 30 years of age. Upon admission 72% of the patients were in ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198510000-00003
更新日期:1985-10-01 00:00:00
abstract:OBJECTIVE:To assess the effect of a positive urine screen for cocaine on thyrotropin (TSH, also thyroid-stimulating hormone) concentrations. METHODS:In this retrospective cohort study, patients admitted to the mental health unit at an academic inpatient setting with a diagnosis of cocaine dependence or cocaine intoxic...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000239
更新日期:2015-02-01 00:00:00
abstract::The clinical course and long-term survival of a patient with acute disseminated histiocytosis X and extrahypothalamic CNS involement were presented. The clinical significance of histiocytes appearing in the CSF cocomitant with the onset of this neurologic syndrome was discussed. Detailed cytologic examination of the C...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1977-11-01 00:00:00
abstract::We have used the island gluteus maximus musculocutaneous flap to cover sacral pressure sores. In this report, we describe the surgical anatomy, cadaveric dissections (n = 25), and postoperative follow-up (one to 40 months) in 13 clinical cases. Our results compare favorably with those of other previously reported seri...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章
doi:
更新日期:1985-10-01 00:00:00
abstract::We evaluated the medical history, physical examination, and laboratory tests done on 245 patients with laparoscopically proven ectopic pregnancies. The absence of abdominal pain was the only clinically useful negative predictive value (91%) regarding tubal rupture. Although mean levels of serum human chorionic gonadot...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199112000-00014
更新日期:1991-12-01 00:00:00
abstract::The oropharyngeal function study is a videotaped radiographic examination of the oropharynx and cervical esophagus used in patients who are at major risk for aspiration because of swallowing difficulty. Preceding the radiographic evaluation, the patient is assessed clinically by a swallowing therapist who attends the ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199002000-00013
更新日期:1990-02-01 00:00:00
abstract:OBJECTIVES:Peripheral vascular disease (PVD) is underdiagnosed in primary care due to the absence of established criteria to warrant diagnostic testing. Our goal was to establish a risk factor hierarchy to enable earlier diagnosis of PVD. METHODS:Data sets of 142 patients with abnormal ankle brachial indices (ABI) wer...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000141303.47034.46
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:Few tests of functional motor behavior are useful for rapidly screening people for lower extremity peripheral neuropathy. The goal of this study was to improve the widely used tandem walking (TW) test. METHODS:We tested "normal" (control) adult and ambulatory patients with peripheral neuropathy (PN) with the...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章
doi:10.1097/SMJ.0000000000000009
更新日期:2013-10-01 00:00:00
abstract::Attention deficit hyperactivity disorder (ADHD) persists into adulthood in up to 60% of cases with childhood onset. A childhood history of ADHD is a prerequisite for making the ADHD diagnosis in an adult. The Utah, Copeland, and Brown self-rating scales are useful in helping the primary care physician confirm the diag...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:
更新日期:2002-07-01 00:00:00
abstract::An unusual intestinal infection with the parasite Metagonimus yokogawai was acquired by an American traveling in the Orient. Diarrhea began abroad, and recurred at intervals until she was seen 1 1/2 years later. Stool examinations resulted in the recovery of small operculated ova characteristic of intestinal or biliar...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197812000-00020
更新日期:1978-12-01 00:00:00
abstract::We have described clostridial sepsis in a child who presented with an abdominal crisis of sickle cell disease. Clostridium paraputrificum should be included in the list of organisms known to cause sepsis in patients with sickle cell anemia. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198012000-00033
更新日期:1980-12-01 00:00:00
abstract:BACKGROUND:In recent years, more and more discussions have arisen with regard to the role of (partially) hydrolyzed formulas as standard feedings for infants with a high risk to have allergy. METHODS:This review is based on an extensive overview of the literature dealing with the subjects of allergy prevention and hyd...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199712000-00002
更新日期:1997-12-01 00:00:00
abstract::Psychiatric hospital services for adolescents have steadily increased in recent years and great interest has been generated in determining treatment outcome. In this study, 74 adolescent inpatients completed structured telephone interviews one year after discharge. The questions probed school, job, and family adjustme...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198009000-00013
更新日期:1980-09-01 00:00:00
abstract::Of ten patients with anterior diaphragmatic hernia treated by operation, only three had shortness of breath and chest pain. The remainder of the patients were referred to us because of a roentgenographic abnormality. All patients have had follow-up of between six months and 11 years without recurrence. Surgical repair...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198203000-00008
更新日期:1982-03-01 00:00:00
abstract::A woman with chronic hemoptysis as her only complaint had extensive testing and did not respond to antibiotic therapy. Radiologic examination of the sinuses identified a mass which, on surgical exploration, was found to be the result of a fungus, Pseudallescheria boydii. Although this fungus is known to be a cause of ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199507000-00021
更新日期:1995-07-01 00:00:00
abstract:OBJECTIVES:The need for colonoscopy is common among diabetic patients. However, there are no standards per se for bowel preparation in patients with type 2 diabetes. In this study, we evaluated the efficacy, safety, and tolerability of sodium phosphate (NaP), and the quality of bowel cleansing in relation to glycemic c...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181f20b13
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVES:Code status specifies the action that healthcare providers should take in the event of cardiac arrest. Studies have shown, however, that patients with do-not-resuscitate/do-not-intubate (DNR/DNI) orders have worse outcomes and do not consistently receive the standard of care. Several studies have demonstrate...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000001112
更新日期:2020-07-01 00:00:00
abstract::A patient with biopsy-proven interstitial nephritis associated with nafcillin and dicloxacillin therapy developed fever, hematuria, pyuria, and renal insufficiency after the administration of carbenicilin five months later. Cephalosporin therapy was given to this patient without signs of renal toxicity. This is the fi...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197801000-00028
更新日期:1978-01-01 00:00:00