Abstract:
:A three-year prospective study during the entire course of preventive therapy with isoniazid (INH) for recently infected hospital employees was undertaken to evaluate the risk of developing INH-related hepatic injury. Results of clinical and laboratory tests at 1, 2, 6, and 12 months were correlated to ascertain the significance and value of monitoring procedures. Thirty-two (32%) of 100 employees developed elevated SGOT levels: one (1%) patient developed clinical hepatitis in the first month of therapy; four (4%) subjects with SGOT elevations (82-378 units) became clinically symptomatic at one to four months and INH was discontinued; one (1%) individual with minimal increases in serum bilirubin and SGOT levels was symptomatic at eight months and the drug was stopped. Twenty-four (24%) otherwise asymptomatic subjects who developed SGOT elevations (70-480 units) were followed at closer intervals to complete INH therapy without further progression of liver function abnormality. The intervals between the beginning of treatment and the elevation of SGOT levels varied widely, with elevations occurring throughout the 12-month course of isoniazid therapy.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Atuk NO,Hart AD,Hunt EHdoi
10.1097/00007611-197702000-00009subject
Has Abstractpub_date
1977-02-01 00:00:00pages
156-9issue
2eissn
0038-4348issn
1541-8243journal_volume
70pub_type
杂志文章abstract::The ultimate evolution of our case and its atypical features of unilateral blindness, bilateral involvement, and extensive involvement of the trigeminal nerve revealed the pathogenesis of this case of alternating painful ophthalmoplegia resembling the Tolosa-Hunt syndrome to be that of a parasellar pituitary adenoma. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198010000-00033
更新日期:1980-10-01 00:00:00
abstract::We describe a patient with pseudotumor cerebri for which a lumboperitoneal (LP) shunt was placed. After a pseudomeningocele was noted at the lumbar incision site, an LP shunt revision was done, at which time migration of the catheter into the thecal sac was noted. Three months later, radiologic studies revealed crania...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199606000-00019
更新日期:1996-06-01 00:00:00
abstract::We have described a patient with fatal Corynebacterium hemolyticum endocarditis on a native bicuspid aortic valve. This is the first report of endocarditis and the first fatal infection of any kind caused by Corynebacterium hemolyticum. This organism and other nondiphtheria corynebacteria must be considered as potenti...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198510000-00030
更新日期:1985-10-01 00:00:00
abstract:BACKGROUND:Oxybutynin is a tertiary amine and has chemical similarities like protamine sulfate. Protamine sulfate's effect on bacterial viability has been shown in some studies; however, there is scanty data regarding the effect of oxybutynin on bacterial viability. Accordingly, the aim of the present study was to inve...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.smj.0000305885.23903.71
更新日期:2008-03-01 00:00:00
abstract::We have reported a case of spontaneous dissection of the internal carotid artery, with MRI and angiographic findings. We conclude that MRI is a beneficial noninvasive test for the detection and study of carotid artery dissection. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199109000-00021
更新日期:1991-09-01 00:00:00
abstract:OBJECTIVES:Atrial fibrillation (AF) has been suggested as a cause for pulmonary embolism (PE). We aimed to explore the prevalence and clinical impact of AF in patients with PE. METHODS:Using the 2012-2014 National (Nationwide) Inpatient Sample database, we identified "adult patients with PE" as the principal discharge...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000001059
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Our objective was to improve breastfeeding initiation rates at an urban medical center. METHODS:A breastfeeding educational program for health care providers was developed and implemented in 1995. The outcome variable of interest was the change in breastfeeding initiation rate during 2 periods, 1993-1994 an...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2002-08-01 00:00:00
abstract::We recently managed a patient with diabetic ketoacidosis who had an exceptionally high arterial oxygen tension of 144 mm Hg while breathing room air. This was higher than the calculated alveolar oxygen tension and suggested the impossible situation of an uphill diffusion gradient. We were surprised to find this is a r...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197909000-00013
更新日期:1979-09-01 00:00:00
abstract:BACKGROUND:Recent studies on the impact of rib fractures after blunt trauma have shown a linear relationship between age, increasing number of rib fractures, and complications, including mortality. Others have documented that age-related morbidity increases before age 65 in trauma patients. We hypothesize that patients...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.smj.0000203815.29757.d3
更新日期:2006-04-01 00:00:00
abstract::Sixty-six cases of serologically documented Rocky Mountain spotted fever (RMSF) from North Carolina are reviewed. Gastrointestinal manifestations were present in 80% of these patients. Because other common expressions of RMSF occasionally do not accompany severe gastrointestinal dysfunction, improper diagnosis and the...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197806000-00007
更新日期:1978-06-01 00:00:00
abstract::We surveyed 1528 first-year students at the University of Virginia, 1 month after their arrival on campus, who had used alcohol at some time in their lives. Our survey was designed to identify alcohol and cocaine use, and related psychosocial patterns. Men drank more and more often than women. Our data suggest that bo...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199101000-00005
更新日期:1991-01-01 00:00:00
abstract::Extraskeletal dedifferentiated chondrosarcomas (DC) are uncommon tumors that predominantly occur in the head and neck. Herein, we describe a case of pulmonary DC detected in a patient with systemic sclerosis and presenting with a symptomatic large pleural effusion and a pulmonary lobar consolidation on chest imaging. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181ad6236
更新日期:2009-08-01 00:00:00
abstract::We report the case of a term newborn with vein of Galen aneurysm. No antenatal diagnosis was done. The infant was admitted secondary to cardiac failure, with cardiomegaly and pulmonary hypertension. Physical examination was remarkable for acrocyanosis, microcephaly, cranial bruit, bilateral neck swelling, coarse breat...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-200405000-00020
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVES:Adhesive capsulitis is characterized by a progressive and painful loss of shoulder motion of unknown etiology. Previous studies have found the prevalence of adhesive capsulitis to be slightly greater than 2% in the general population. However, the relationship between adhesive capsulitis and diabetes mellitu...
journal_title:Southern medical journal
pub_type: 杂志文章,多中心研究
doi:10.1097/SMJ.0b013e3181705d39
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVES:Current US healthcare delivery systems do not adequately address healthcare demands. Physicians are integral but rarely emphasize prevention as a primary tool to change health outcomes. Home visitation is an effective method for changing health outcomes in some populations. The Florida International Universi...
journal_title:Southern medical journal
pub_type: 杂志文章,随机对照试验
doi:10.1097/SMJ.0000000000000080
更新日期:2014-04-01 00:00:00
abstract::An elderly man with previous tuberculosis exsanguinated from esophageal rupture of an atherosclerotic thoracic aneurysm. Because the patient refused angiography, the source of bleeding was discovered only at autopsy. Selected clinical and pathologic aspects of the case are discussed in relation to the different causes...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197907000-00042
更新日期:1979-07-01 00:00:00
abstract::Forty-four patients with metastatic brain neoplasms received glycerol instead of corticosteroids during periods of brain irradiation. Headache, nausea, and vomiting were controlled in more than 90% of symptomatic patients, while paralysis, confusion, and papilledema improved in 55% to 80%. Patients with minimal or no ...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章
doi:
更新日期:1980-09-01 00:00:00
abstract::We evaluated the medical history, physical examination, and laboratory tests done on 245 patients with laparoscopically proven ectopic pregnancies. The absence of abdominal pain was the only clinically useful negative predictive value (91%) regarding tubal rupture. Although mean levels of serum human chorionic gonadot...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199112000-00014
更新日期:1991-12-01 00:00:00
abstract::Most nonendocrine pancreatic neoplasms are adenocarcinomas of ductal cell or acinar origin. Primary carcinomas of the pancreas with squamous differentiation are rare enough to warrant a search for other primary tumors. In the past few decades, well-documented individual reports and large series reviews support the vie...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2000-08-01 00:00:00
abstract::A cross-sectional survey of a total semirural biracial population of children was conducted to determine the prevalence and types of cardiac disease. Of 4,074 children examined, 146 were thought to have significant cardiac murmurs. One hundred thirteen of these participated in a follow-up study in which they received ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198210000-00006
更新日期:1982-10-01 00:00:00
abstract:BACKGROUND:This study was done to determine the safety, efficacy, dosing requirements, and spontaneous recovery profiles of prolonged infusions of rocuronium bromide in the critically ill. METHODS:This multicenter, prospective, nonrandomized, open label trial enrolled 32 patients at two university-based medical center...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:2001-01-01 00:00:00
abstract::A 27-year-old man had recurrent abscesses of the thigh caused by organisms typical of mouth flora. The unusual identity of these organisms from a thigh abscess led to the recognition that the illness was induced by self-injection with saliva, and that the patient had many of the characteristics of Münchausen's syndrom...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1979-02-01 00:00:00
abstract:BACKGROUND:Chlamydia is the most commonly reported infectious disease in the United States, yet many women at risk for chlamydia infection are not being tested. METHODS:We conducted a chlamydia screening study (Phase I) and retrospective medical chart review (Phase II) of 199 women from 16 to 40 years of age attending...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000053673.13882.00
更新日期:2003-09-01 00:00:00
abstract::Atomoxetine (Strattera®, Eli Lilly and Co.) is the first non-stimulant drug in the United States (US) to be approved for the treatment of attention deficit hyperactivity disorder (ADHD). In the past, physicians have been concerned about the safety of a variety of ADHD medications. As a result, non-stimulant drugs were...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e318205e575
更新日期:2011-02-01 00:00:00
abstract::The accuracy of the noninvasive carotid system studies done in our laboratory during an 18-month period were reviewed. The usefulness of these procedures was found to be limited when used as a "blind" screen for extracranial vascular disease. The overall correlation with angiography was good, with few false-negatives ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198205000-00008
更新日期:1982-05-01 00:00:00
abstract::The demented patient requires medical and often psychiatric supervision, but the caregiver is often neglected. This article identifies special issues for caregivers that may need attention from the demented patient's physician. The physician's attention can benefit both the patient and the caregiver and save the physi...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract::Retrospective review of eight years' experience with the Mallory-Weiss syndrome emphatically supports the need for accurate, early localization of the site of upper gastrointestinal hemorrhage. Pertinent aspects of the history and physical and laboratory evaluation of this group of patients were analyzed to determine ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1979-10-01 00:00:00
abstract::Dysphagia is a commonly encountered patient complaint. The differential diagnosis for dysphagia is extensive. One long-recognized etiology of dysphagia is cervical osteophytosis. Degenerative joint disease, ankylosing spondylosis, and diffuse idiopathic skeletal hyperostosis (DISH) can all cause cervical osteophyte fo...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199708000-00020
更新日期:1997-08-01 00:00:00
abstract::Sickle cell disease (SCD) is the most common hereditary disorder and affects 30 million people worldwide. Advances in science have improved overall survival in patients with SCD and as such, more patients are reaching reproductive age and are becoming pregnant. SCD in pregnancy leads to multiple complications that put...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.14423/SMJ.0000000000000514
更新日期:2016-09-01 00:00:00
abstract::In 1954 I described a case of chronic fluoride poisoning from artificially fluoridated water, in which the patient exhibited a multisymptomatic clinical picture without noticeable skeletal changes. Subsequently, others and I have confirmed this "nonskeletal phase" of the disease from fluoride in water and in air (in w...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1980-03-01 00:00:00