Abstract:
BACKGROUND:This study was done to determine the safety, efficacy, dosing requirements, and spontaneous recovery profiles of prolonged infusions of rocuronium bromide in the critically ill. METHODS:This multicenter, prospective, nonrandomized, open label trial enrolled 32 patients at two university-based medical centers. Patients who were determined to require neuromuscular blockade for at least 24 hours received a bolus of 0.6 mg/kg of rocuronium. After subsequent recovery of two responses (T2) to the TOF stimulation, an infusion of rocuronium was begun at 10 microg/kg/min and continued for 24 to 120 hours as required by the patients' clinical status. RESULTS:Patients were divided into multiple organ failure (MOF) and non-multiple organ failure (non-MOF) groups on enrollment. The mean infusion rates for the MOF and non-MOF groups were 0.2 and 0.5 mg/kg/hour, respectively. CONCLUSION:The mean infusion rate of rocuronium that provides approximately 90% blockade is less for critically ill patients with MOF. Spontaneous recovery was prolonged in patients with MOF.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Circeo LE,Reeves STsubject
Has Abstractpub_date
2001-01-01 00:00:00pages
36-42issue
1eissn
0038-4348issn
1541-8243journal_volume
94pub_type
临床试验,杂志文章,多中心研究abstract::In a retrospective study of all patients who had pulmonary embolism during a 37-year span at M. D. Anderson Hospital, we identified 502 patients, 30 of whom had a primary malignancy in the head and neck region. Only five of these patients had a clinically significant pulmonary embolus during the immediate postoperativ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198909000-00013
更新日期:1989-09-01 00:00:00
abstract::Computed tomography (CT) is increasingly used to evaluate abdominal diseases, including those of the colon. Recent CT studies have documented colonic abnormalities in patients with pseudomembranous colitis; however, these findings are not widely appreciated by primary care physicians. Over a 25-month period, we prospe...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199509000-00008
更新日期:1995-09-01 00:00:00
abstract::Endocrine metabolic emergencies are common clinical entities seen by most health care professionals in acute care medicine. Except for cardiopulmonary arrest, few situations require such rapid institution of immediate drug therapy to reverse life-threatening metabolic imbalances. To safely guide patients through these...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-198402000-00021
更新日期:1984-02-01 00:00:00
abstract::A patient with pathologically proven acrometastasis of his left thumb presented 3 months after esophagectomy for esophageal squamous cell carcinoma. Interestingly, there was indeed a faint uptake in his left thumb that was initially considered an artifact in the whole body bone scan taken before esophagectomy. Physici...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e31817bf9be
更新日期:2008-11-01 00:00:00
abstract::Hypochlorhydric states such as atrophic gastritis and partial gastrectomy have long been known to cause iron deficiency anemia. However, studies to date have failed to show a similar association with omeprazole, a proton pump inhibitor that also produces achlorhydria. These studies, however, have primarily involved no...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000110405.63179.69
更新日期:2004-09-01 00:00:00
abstract::Elevation in fasting serum gastrin levels was found in three patients being evaluated for persistent upper abdominal pain without radiographic evidence of peptic ulcer disease. Fiberoptic endoscopy of the upper gastrointestinal tract in each patient revealed characteristic changes of chronic atrophic gastritis. Gastri...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197612000-00010
更新日期:1976-12-01 00:00:00
abstract::Dysphagia is a commonly encountered patient complaint. The differential diagnosis for dysphagia is extensive. One long-recognized etiology of dysphagia is cervical osteophytosis. Degenerative joint disease, ankylosing spondylosis, and diffuse idiopathic skeletal hyperostosis (DISH) can all cause cervical osteophyte fo...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199708000-00020
更新日期:1997-08-01 00:00:00
abstract:OBJECTIVES:Despite the efforts of various leading organizations in medical education, representation of black students in US medical schools has declined since the mid-1990s. The Florida State University College of Medicine (FSUCOM) has undertaken efforts to increase black and other underrepresented minority in medicin...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000792
更新日期:2018-04-01 00:00:00
abstract::Coronary heart disease remains the major cause of mortality and morbidity in the United States and other western countries despite major advances in its treatment. During the last decades, many markers of coronary artery disease have been found which help predict future risk of cardiovascular events. High-sensitivity ...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/SMJ.0b013e31816c0195
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:This study was done to determine the accuracy of the 2 x 2 cm pocket identifying low amniotic fluid (AF) volume in singleton and twin pregnancies. METHODS:The AF volume was evaluated by ultrasonography for the presence of a 2 x 2 cm pocket before amniocentesis. The actual AF volume was then determined by a ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199908000-00011
更新日期:1999-08-01 00:00:00
abstract::Over a period of one year, 1986-1987, 116 strains of Staphylococcus aureus were isolated from patients attending two outpatient dermatology clinics in Houston, Texas. The purpose of this study was to evaluate the adequacy of routine antibiotic sensitivity testing methods for detecting methicillin-resistant Staphylococ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198902000-00005
更新日期:1989-02-01 00:00:00
abstract::A woman with stable diabetes presented with hypoglycemia and decreased insulin requirement. Further history suggested decreasing pituitary function. Laboratory tests confirmed pituitary deficiencies, associated with her increased insulin sensitivity. It may be helpful to be aware of this syndrome when dealing with dia...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198001000-00033
更新日期:1980-01-01 00:00:00
abstract::Two patients with retained laparotomy pads after laparotomy had pain, abscess formation, and bleeding, with erosion of the pad into the small bowel and colon. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198604000-00026
更新日期:1986-04-01 00:00:00
abstract::Reported is the fifth known case of Addison's disease due to adrenal involvement by North American blastomycosis (Blastomyces dermatitidis infection). The fact that amphotericin B therapy precipitated an addisonian crisis suggests that patients with disseminated blastomycosis should have their adrenal function and res...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197707000-00028
更新日期:1977-07-01 00:00:00
abstract::Semiquantitative amniotic fluid volume (AFV) determination is a component of the fetal biophysical profile (BPP). To assess decreased AVF we did BPPs of 174 fetuses within 1 week of delivery. Two methods were used: measurement of the single largest vertical pocket (oligohydramnios = depth < 1 cm) and the four-quadrant...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199304000-00011
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:Despite an effective tetanus vaccine, tetanus continues to claim lives worldwide. The very young and the elderly are at highest risk for the disease. Farmers are at high risk for injury, the leading factor associated with tetanus. METHODS:As part of a larger study of older members of farm households in the ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e31818f6544
更新日期:2009-03-01 00:00:00
abstract::Pyridium (phenazopyridine hydrochloride) is often prescribed as an analgesic in patients following trauma, surgery, or infections of the urinary tract. Pyridium toxicity has been previously reported, however, most cases result in a single adverse effect. Herein the authors describe an elderly patient who presented wit...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.smj.0000197299.77949.16
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVES:To design and implement a formal otolaryngology inpatient consultation service that improves satisfaction of consulting services, increases educational opportunities, improves the quality of patient care, and ensures sustainability after implementation. METHODS:This was a retrospective cohort study in a lar...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000763
更新日期:2018-02-01 00:00:00
abstract::All indexed cases of typhoid fever occurring in children over a ten-year period in Jacksonville, Fla, were studied retrospectively. This review revealed that anorexia was the most common gastrointestinal complaint and that neurologic symptoms and signs were nearly as common as gastrointestinal signs. There was a signi...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197902000-00008
更新日期:1979-02-01 00:00:00
abstract::Hypothyroidism is a common condition. Rarely, it may occur in combination with autoimmune failure of other endocrine glands (autoimmune polyendocrinopathy syndrome type 2, previously known as Schmidt's syndrome). In such cases, restoring normal thyroid function may precipitate adrenal failure. Clinicians should have a...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000056647.58668.CD
更新日期:2003-08-01 00:00:00
abstract::In the past 30 years there has been no improvement in the five-year survival rate for endometrial carcinoma. Any change comparable to improved survival in cervical carcinoma will be accomplished only by similar detection of the early asymptomatic and precursor lesions of endometrial carcinoma. Reasons why the conventi...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198004000-00022
更新日期:1980-04-01 00:00:00
abstract::We report a case of multiple myeloma in which the bone lesions showed high uptake of technetium Tc 99m methylene diphosphonate on a bone scan. A review of the literature comparing the usefulness of conventional skeletal radiography and bone scans in diagnosing the osteolytic lesions of myeloma shows that bone scintigr...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2000-10-01 00:00:00
abstract:OBJECTIVES:The need for colonoscopy is common among diabetic patients. However, there are no standards per se for bowel preparation in patients with type 2 diabetes. In this study, we evaluated the efficacy, safety, and tolerability of sodium phosphate (NaP), and the quality of bowel cleansing in relation to glycemic c...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181f20b13
更新日期:2010-11-01 00:00:00
abstract::Most patients with heart failure today are treated by primary care practitioners, not cardiologists. The Consensus Recommendations for the Management of Chronic Heart Failure, developed by the Advisory Council to Improve Outcomes Nationwide in Heart Failure, provide practice guidelines for the prevention, diagnosis, a...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2001-02-01 00:00:00
abstract::Cobalamin (vitamin B12) deficiency warrants appropriate evaluation because cobalamin is necessary in certain biochemical functions. R-binder deficiency, which causes low cobalamin levels, is a rare and benign pseudodeficiency. If not further evaluated by determining levels of methylmalonic acid and homocysteine, howev...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2002-09-01 00:00:00
abstract::Cardiac rupture due to blunt trauma has been recognized with increasing frequency over the past two decades. The mortality rate is high and the majority of patients die before they arrive at the emergency department. A high index of suspicion and prompt surgical intervention are crucial for survival. We report the man...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199707000-00019
更新日期:1997-07-01 00:00:00
abstract::Plasma cell granuloma of the thyroid is a rare tumor-like lesion formed by a localized proliferation of inflammatory cells, supported by a stroma of fibrous tissue. Few cases have been previously reported in the medical literature. We report a new case of a 41-year-old man presenting a goiter with primary hypothyroidi...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-200406000-00018
更新日期:2004-06-01 00:00:00
abstract::We have described a 38-year-old white American woman who had a 7-year history of pain in the left anterior chest, neck, right wrist, and buttocks. The pain fluctuated in severity and appeared to coincide with worsening of her skin condition, palmoplantar pustulosis (PPP). She manifested the typical skeletal features o...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199304000-00021
更新日期:1993-04-01 00:00:00
abstract::Fluoxetine is an antidepressant drug with a unique chemical configuration which enhances serotoninergic transmission by inhibiting serotonin uptake. The chronic presence of serotonin in the synaptic cleft reduces postsynaptic receptors, a postulated explanation for its antidepressant efficacy. Comparative studies show...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:
更新日期:1989-08-01 00:00:00
abstract::A case of brain stem infarction after chiropractic manipulation of the cervical spine is presented. Proposed mechanisms and sites of possible arterial injury are discussed. A diagnosis of vertebral artery occlusion was made using conventional brachial angiography. Digital intravenous angiography, a relatively new and ...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-198312000-00014
更新日期:1983-12-01 00:00:00