Multicenter trial of prolonged infusions of rocuronium bromide in critically ill patients: effects of multiple organ failure.

Abstract:

BACKGROUND:This study was done to determine the safety, efficacy, dosing requirements, and spontaneous recovery profiles of prolonged infusions of rocuronium bromide in the critically ill. METHODS:This multicenter, prospective, nonrandomized, open label trial enrolled 32 patients at two university-based medical centers. Patients who were determined to require neuromuscular blockade for at least 24 hours received a bolus of 0.6 mg/kg of rocuronium. After subsequent recovery of two responses (T2) to the TOF stimulation, an infusion of rocuronium was begun at 10 microg/kg/min and continued for 24 to 120 hours as required by the patients' clinical status. RESULTS:Patients were divided into multiple organ failure (MOF) and non-multiple organ failure (non-MOF) groups on enrollment. The mean infusion rates for the MOF and non-MOF groups were 0.2 and 0.5 mg/kg/hour, respectively. CONCLUSION:The mean infusion rate of rocuronium that provides approximately 90% blockade is less for critically ill patients with MOF. Spontaneous recovery was prolonged in patients with MOF.

journal_name

South Med J

journal_title

Southern medical journal

authors

Circeo LE,Reeves ST

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

36-42

issue

1

eissn

0038-4348

issn

1541-8243

journal_volume

94

pub_type

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