Effect of omeprazole on oral iron replacement in patients with iron deficiency anemia.

Abstract:

:Hypochlorhydric states such as atrophic gastritis and partial gastrectomy have long been known to cause iron deficiency anemia. However, studies to date have failed to show a similar association with omeprazole, a proton pump inhibitor that also produces achlorhydria. These studies, however, have primarily involved nonanemic, iron-replete individuals. The effect of the drug has not been studied in patients with established iron deficiency, and to our knowledge the patients presented here are the first of their kind to be reported. Our observations support the probability that the profound hypochlorhydria induced by omeprazole may indeed impair the optimal absorption of orally administered iron in iron-deficient individuals, precluding them from obtaining therapeutically adequate amounts to establish the positive balance necessary for the resolution of anemia and the replenishment of stores. The possible explanations for this phenomenon are also discussed.

journal_name

South Med J

journal_title

Southern medical journal

authors

Sharma VR,Brannon MA,Carloss EA

doi

10.1097/01.SMJ.0000110405.63179.69

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

887-9

issue

9

eissn

0038-4348

issn

1541-8243

journal_volume

97

pub_type

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