Abstract:
OBJECTIVES:Alloantibody formation secondary to transfusion in patients with sickle cell disease (SCD) is a well-known phenomenon. Pretransfusion testing (eg, "antibody screening") protects patients from receiving incompatible red blood cell transfusions. Because alloantibodies have a tendency to evanesce (ie, become undetectable over time), however, this phenomenon puts patients at risk of a delayed hemolytic transfusion reaction or even acute hemolysis. METHODS:We evaluated the records of 71 patients with SCD with alloantibodies detected during a 2-year period to describe their most common specificities and their rate of evanescence. RESULTS:We found that 81% of patients had at least one antibody that was undetectable during the study period; therefore, if patients were transfused with antigen-positive units at a facility that was unaware of their antibody history, life-threatening hemolysis could develop. CONCLUSIONS:Evanescence is a real risk for patients with SCD, and national/regional databases of alloantibodies should be considered a priority.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Williams LA 3rd,Lorenz RG,Tahir A,Pham HP,Marques MBdoi
10.14423/SMJ.0000000000000528subject
Has Abstractpub_date
2016-09-01 00:00:00pages
588-91issue
9eissn
0038-4348issn
1541-8243pii
SMJ50256journal_volume
109pub_type
杂志文章abstract::In a 61-year-old man with facial diplegia and new onset of congestive heart failure (CHF), electroneuromyography indicated diffuse axonal degeneration, but sural nerve biopsy showed mild changes and no amyloid. Four months later, after the onset of diplopia and increasing CHF, rectal biopsy demonstrated amyloid. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198611000-00037
更新日期:1986-11-01 00:00:00
abstract::Recommendations concerning postoperative extubation after thymectomy for myasthenia gravis are presently based upon retrospective chart reviews. We present the results of a prospective investigation of time to extubation after thymectomy for 14 patients over a 12-month period based upon a protocol that included preope...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199106000-00007
更新日期:1991-06-01 00:00:00
abstract::The importance of considering organic diseases when evaluating catatonic patients is illustrated by two cases of akinetic parkinsonism in which the patients became catatonic, with waxy flexibility. The catatonic syndrome occurs in association with a variety of lesions that may affect any level of the central nervous s...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198606000-00008
更新日期:1986-06-01 00:00:00
abstract::The renin-angiotensin-aldosterone system (RAAS) plays a major role in blood pressure regulation and is thus an important therapeutic target in the management of hypertension. Angiotensin receptor blockers (ARBs), which interrupt RAAS overactivity by blocking a specific receptor that mediates the pathogenic activity of...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/SMJ.0b013e3181e1e2da
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:The effects of chronic diuretic use on serum homocysteine and its metabolic cofactors vitamin B6, vitamin B12, and red blood cell (RBC) folate have not been well studied. METHODS:Blood samples from 17 hypertensive patients receiving long-term diuretic therapy and 17 hypertensive patients not taking diuretic...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章
doi:10.1097/00007611-199909000-00003
更新日期:1999-09-01 00:00:00
abstract::Granular cell tumors (GCT) are rare, usually benign neoplasms of Schwann cell origin. Since discovery in 1926, fewer than 80 cases of GCT involving the lung have been reported. This report presents a 45-year-old male who presented with symptoms consistent with chronic pancreatitis associated with night sweats, weight ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.smj.0000182134.44098.01
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVES:Transcranial Doppler ultrasound (TCD) effectively identifies children with sickle cell anemia (SCA) who are at increased risk of stroke. We evaluated a low-cost quality improvement (QI) intervention to increase the proportion of children screened by TCD. METHODS:We measured the proportion of children with S...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章
doi:10.14423/SMJ.0000000000000517
更新日期:2016-09-01 00:00:00
abstract::Fluoxetine is an antidepressant drug with a unique chemical configuration which enhances serotoninergic transmission by inhibiting serotonin uptake. The chronic presence of serotonin in the synaptic cleft reduces postsynaptic receptors, a postulated explanation for its antidepressant efficacy. Comparative studies show...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:
更新日期:1989-08-01 00:00:00
abstract::Sixty-six cases of serologically documented Rocky Mountain spotted fever (RMSF) from North Carolina are reviewed. Gastrointestinal manifestations were present in 80% of these patients. Because other common expressions of RMSF occasionally do not accompany severe gastrointestinal dysfunction, improper diagnosis and the...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197806000-00007
更新日期:1978-06-01 00:00:00
abstract::"Sick building syndrome" (SBS) is one of the more colorful terms describing an increasingly common pattern of symptoms found among workers in modern office buildings. Core symptoms include lethargy, mucous membrane irritation, headache, eye irritation, and dry skin. To prompt a diagnosis of SBS, these otherwise common...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199101000-00015
更新日期:1991-01-01 00:00:00
abstract::Intracranial aneurysms often present a challenging problem for the neurosurgeon. A variety of techniques have been developed to deal with these lesions. Several subspecialists are frequently involved in such treatment. We present our experience in a community hospital using a previously described technique of hypother...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199308000-00010
更新日期:1993-08-01 00:00:00
abstract::In a patient with an asymptomatic left upper lobe pulmonary arteriovenous fistula, preoperative chest roentgenograms simulated bronchogenic carcinoma, but no overt feeding vessel was demonstrated. Intraoperatively no lesion could be palpated. Postoperative evaluation revealed a pulmonary arteriovenous fistula. This en...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198307000-00017
更新日期:1983-07-01 00:00:00
abstract::The original and most widely accepted applications for point-of-care ultrasound (POCUS) are in the settings of trauma, shock, and bedside procedures. Trauma was the original setting for the introduction of POCUS and has been standardized under the four-plus view examination called the Focused Assessment with Sonograph...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000838
更新日期:2018-07-01 00:00:00
abstract::We have described a patient with community-acquired, methicillin-resistant Staphylococcus epidermidis endocarditis that occurred on a prolapsing mitral valve. The patient was successfully treated with vancomycin and rifampin for six weeks and had no signs of relapse four months later. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1983-09-01 00:00:00
abstract::Seven patients with diabetes of ten to 24 years' duration and renal insufficiency were treated with fluphenazine and amitriptyline in an attempt to control severe pain in the extremities. Six patients had relief of pain within five days of initiation of therapy. One patient had no pain relief despite mood alteration. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1983-04-01 00:00:00
abstract::We have described a patient with fatal Corynebacterium hemolyticum endocarditis on a native bicuspid aortic valve. This is the first report of endocarditis and the first fatal infection of any kind caused by Corynebacterium hemolyticum. This organism and other nondiphtheria corynebacteria must be considered as potenti...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198510000-00030
更新日期:1985-10-01 00:00:00
abstract::Two cases of recurrent psychotic depression are reported in which ECT (electroconvulsive therapy) was administered with good results for previous episodes of depression, but treatment of the current episode with combined drug therapy (antidepressant and antipsychotic drugs) in one case and antidepressant chemotherapy ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197812000-00021
更新日期:1978-12-01 00:00:00
abstract:BACKGROUND:Non-insulin-dependent diabetes mellitus (NIDDM) and hyperhomocysteinemia are both associated with increased lipid peroxidation (oxidative stress). This may contribute to the accelerated vascular disease associated with these conditions. It is not known whether the coexistence of elevated homocysteine levels ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199709000-00008
更新日期:1997-09-01 00:00:00
abstract::We have reported a case of intraduodenal duct disruption and duodenal hematoma associated with ERCP. The location of the extravasated contrast material created a confusing picture, which preoperatively was thought to be a pseudocyst, but was found at operation to be a duodenal hematoma. In retrospect, the upper gastro...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198711000-00027
更新日期:1987-11-01 00:00:00
abstract::We have described clostridial sepsis in a child who presented with an abdominal crisis of sickle cell disease. Clostridium paraputrificum should be included in the list of organisms known to cause sepsis in patients with sickle cell anemia. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198012000-00033
更新日期:1980-12-01 00:00:00
abstract::The use of silver wire retention sutures requires added operating room time and expense, and it incurs the potential hazards of caught viscera, the possibility of more adhesions, leakage of intraperitoneal fluid through the exit wound, mild infection of exit wounds, and, on removal of the sutures, pain despite sedatio...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197905000-00013
更新日期:1979-05-01 00:00:00
abstract:OBJECTIVES:To determine the prevalence of overweight in a cardiac stress testing population, and the percentage of subjects who indicate a history of overweight. METHODS:A total of 251 consecutive subjects presenting for cardiac stress testing in a 450-bed community hospital from June to September 2010 were asked to c...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e31821e9359
更新日期:2011-07-01 00:00:00
abstract::Brown recluse spider bites may result in extensive soft tissue injury, causing months of disability. We have described a patient who had a series of extensive surgical debridements after envenomation. Despite skin grafting, persistent cutaneous lesions and extensive satellitosis progressed to involve the entire lower ...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199002000-00029
更新日期:1990-02-01 00:00:00
abstract::Anticonvulsant hypersensitivity syndrome (AHS) is a potentially life-threatening adverse drug reaction presenting with fever, skin eruptions, and internal organ involvement. We describe a case of AHS with fulminant hepatitis that occurred two weeks after introduction of lamotrigine in a 40-year-old female patient with...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/SMJ.0b013e3181878b95
更新日期:2009-01-01 00:00:00
abstract::We have reported a fatal complication of a therapeutic dose of ipecac syrup administered in a hospital emergency room. This child received 15 ml of ipecac syrup shortly after ingesting one to five tablets of chlorpheniramine maleate (4 mg). A prolonged course of vomiting (more than 24 hours) eventually resulted in gas...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198706000-00031
更新日期:1987-06-01 00:00:00
abstract::We retrospectively analyzed experience with total gastrectomy (TG) for gastric carcinoma in 23 patients. The TNM stage was I in one patient, II in one patient, III in eight patients, and IV in 13. Linitis plastica was found in ten patients. The operation was considered curative in only eight patients (35%). There were...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-198908000-00011
更新日期:1989-08-01 00:00:00
abstract::We recently managed a patient with diabetic ketoacidosis who had an exceptionally high arterial oxygen tension of 144 mm Hg while breathing room air. This was higher than the calculated alveolar oxygen tension and suggested the impossible situation of an uphill diffusion gradient. We were surprised to find this is a r...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197909000-00013
更新日期:1979-09-01 00:00:00
abstract::Despite the simplicity, effectiveness, and safety of spinal anesthesia, arachnoiditis can occur as a complication. The cause of this is often unknown, especially since disposable spinal kits are now normally used. It is postulated that an untoward reaction to the anesthesia or chemical contamination was the cause of a...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199311000-00026
更新日期:1993-11-01 00:00:00
abstract::Patients with non-insulin-dependent diabetes mellitus (NIDDM) failing to respond to therapy with a maximum dose of glyburide (GB) or glipizide (GZ) are often given a trial of the alternate second-generation sulfonylurea (SGS) before insulin therapy is considered. The efficacy of this therapeutic maneuver has not been ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199106000-00017
更新日期:1991-06-01 00:00:00
abstract::Inhalation abuse of volatile solvents, previously known generically as "glue sniffing," is typically pursued by adolescents. A wide range of legal, easily obtained products containing volatile substances are available for abuse. We report two illustrative cases of fatal volatile substance abuse: gasoline sniffing in a...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00