High Percentage of Evanescent Red Cell Antibodies in Patients with Sickle Cell Disease Highlights Need for a National Antibody Database.

Abstract:

OBJECTIVES:Alloantibody formation secondary to transfusion in patients with sickle cell disease (SCD) is a well-known phenomenon. Pretransfusion testing (eg, "antibody screening") protects patients from receiving incompatible red blood cell transfusions. Because alloantibodies have a tendency to evanesce (ie, become undetectable over time), however, this phenomenon puts patients at risk of a delayed hemolytic transfusion reaction or even acute hemolysis. METHODS:We evaluated the records of 71 patients with SCD with alloantibodies detected during a 2-year period to describe their most common specificities and their rate of evanescence. RESULTS:We found that 81% of patients had at least one antibody that was undetectable during the study period; therefore, if patients were transfused with antigen-positive units at a facility that was unaware of their antibody history, life-threatening hemolysis could develop. CONCLUSIONS:Evanescence is a real risk for patients with SCD, and national/regional databases of alloantibodies should be considered a priority.

journal_name

South Med J

journal_title

Southern medical journal

authors

Williams LA 3rd,Lorenz RG,Tahir A,Pham HP,Marques MB

doi

10.14423/SMJ.0000000000000528

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

588-91

issue

9

eissn

0038-4348

issn

1541-8243

pii

SMJ50256

journal_volume

109

pub_type

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