Abstract:
OBJECTIVE:Decreased bone mineral density has been found in the advanced stages of various lung diseases. Limited data are available about prevalence and risk factors for osteoporosis/osteopenia (OP) in pulmonary arterial hypertension (PAH). METHODS:Patients with PAH (either idiopathic or secondary to scleroderma [SSC-PAH]) who underwent bone density testing for lung transplant evaluation were included. Results of bone density testing, demographic data, pulmonary function testing, hemodynamic measures, and 6-minute walk distance test (6MWD) were collected. RESULTS:Thirty-two patients were identified (27 women/5 men, 24 idiopathic PAH/8 SSC-PAH) and OP was found in 22 (69%) patients. Patients with SSC-PAH had more significant indications of OP at all of the measured sites. The OP group had lower FEV1 (P = 0.01) and a significantly lower 6MWD (P = 0.04) as compared with patients with PAH with normal bone density. Hemodynamics indicated no statistically significant differences between the groups other than a lower mean pulmonary artery pressure (P = 0.01) in the OP group. Patients with a history of corticosteroid use and smoking, postmenopausal status, decreased functional capacity (as measured by poor New York Heart Association functional class and 6MWD), SSC-PAH, and need for oxygen during a 6MWD test had an increased risk of OP by univariate logistic regression. CONCLUSIONS:Reduced bone density can be seen in a majority of patients with advanced PAH. Risk factors for reduced bone density include SSC-PAH, reduced 6MWD, need for oxygen during 6MWD testing, reduced FEV1, a history of smoking or corticosteroid use, and postmenopausal status.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Malik N,McCarthy K,Minai OAdoi
10.1097/SMJ.0b013e31825b8117subject
Has Abstractpub_date
2012-07-01 00:00:00pages
344-9issue
7eissn
0038-4348issn
1541-8243pii
00007611-201207000-00005journal_volume
105pub_type
杂志文章abstract::Semiquantitative amniotic fluid volume (AFV) determination is a component of the fetal biophysical profile (BPP). To assess decreased AVF we did BPPs of 174 fetuses within 1 week of delivery. Two methods were used: measurement of the single largest vertical pocket (oligohydramnios = depth < 1 cm) and the four-quadrant...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199304000-00011
更新日期:1993-04-01 00:00:00
abstract::Human ehrlichiosis is a tick-borne rickettsial disease characterized by fever, headache, myalgias, anorexia, and occasionally rash. In our patient, changes in mental status, upper motor neuron signs, cerebrospinal fluid pleocytosis, and increased serum protein levels were found in association with serologically confir...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199011000-00031
更新日期:1990-11-01 00:00:00
abstract::Radiation therapy and/or chemotherapy are the treatment modalities of choice in lymphomas. Except for Burkitt's tumor, surgery is usually indicated only when percutaneous biopsy fails to establish the histologic diagnosis. We have described a patient with glomerulonephritis and anasarca secondary to an IgM-producing p...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198211000-00030
更新日期:1982-11-01 00:00:00
abstract::Because of the persistently high mortality from sepsis in cancer patients, a retrospective study was designed to identify the causative organisms and to determine the factors affecting the outcome of sepsis. A total of 84 episodes of septicemia in 61 children with cancer were studied. The more frequently isolated orga...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197902000-00007
更新日期:1979-02-01 00:00:00
abstract::Though low, the incidence of malaria in the United States is not insignificant and can be the source of infection in febrile travelers returning from endemic areas. Clinicians practicing in the United States must have a basic understanding of the malaria life cycle and its treatments to properly diagnose and treat thi...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/01.smj.0000189904.50838.eb
更新日期:2005-12-01 00:00:00
abstract::Bleeding is the most serious complication of thrombolytic therapy and limits its usefulness. We have reported a case of epidural hematoma, a rare occurrence after combined therapy with tissue plasminogen activator (TPA) and heparin. We emphasize that in patients treated with thrombolytic agents, any trauma may increas...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1991-05-01 00:00:00
abstract::Lyme disease, now the most common tick-borne illness in the United States, has recently received much media attention, due in part to its potentially serious sequelae in untreated patients. Because a rare patient with late illness may lack antibodies to the etiologic agent, Borrelia burgdorferi, physicians may be temp...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199110000-00024
更新日期:1991-10-01 00:00:00
abstract::We reviewed the results of lymphocyte karyotypes from 232 couples who had had two or more pregnancy losses (spontaneous abortions or stillbirths). Despite the use of strict criteria to correct for possible bias of ascertainment, 8% of these couples (19 of 232) had a chromosome abnormality. Six of these abnormalities w...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198812000-00014
更新日期:1988-12-01 00:00:00
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journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1976-03-01 00:00:00
abstract::Ten bites by Loxosceles reclusa, the North American brown recluse spider, are reported from South Carolina. Envenomation by the brown recluse spider is becoming a public health problem in the United States. The spider reportedly now is found from coast to coast in the southern half of the country and its range is prob...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197607000-00024
更新日期:1976-07-01 00:00:00
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journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199812000-00002
更新日期:1998-12-01 00:00:00
abstract::Documented fetal inactivity is strongly suggestive of fetal jeopardy, but the significance of excessive activity over a prolonged period has not been reported. Using data gathered from fetal movement charts recorded by 931 patients, fetal hyperactivity was defined statistically as 40 or more movements perceived per ho...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198302000-00005
更新日期:1983-02-01 00:00:00
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journal_title:Southern medical journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007611-199010000-00005
更新日期:1990-10-01 00:00:00
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journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000486
更新日期:2016-07-01 00:00:00
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journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::We have reported a third case of miliary tuberculosis and associated consumption coagulopathy. It is proposed that clotting factors may be locally consumed, thus producing the syndrome of "multifocal vasculopathic coagulation." ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197911000-00042
更新日期:1979-11-01 00:00:00
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journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199807000-00012
更新日期:1998-07-01 00:00:00
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journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197509000-00021
更新日期:1975-09-01 00:00:00
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journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1976-04-01 00:00:00
abstract::The National Cholesterol Education Program and physician/patient awareness of the risks of hypercholesterolemia have resulted in aggressive screening and treatment of elevated cholesterol levels. The "one size fits all" concept has been used as the criterion for intervention. However, this has been promulgated without...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199310001-00003
更新日期:1993-10-01 00:00:00
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journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199007000-00015
更新日期:1990-07-01 00:00:00
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journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:
更新日期:2000-02-01 00:00:00
abstract::Nearly three million persons in the United States are viremic with hepatitis C (HCV). Despite a decreasing incidence of HCV in this country, the prevalence of HCV-related chronic liver disease is increasing. Most infections in the United States are acquired by intravenous drug use. The chronicity rate of HCV is high, ...
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pub_type: 杂志文章,评审
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更新日期:2004-04-01 00:00:00
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journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2001-02-01 00:00:00
abstract::A case of left renocolic fistula secondary to chronic pyonephrosis has been reported. Neprectomy, excision of the fistulous tract, and closure of the colon is the treatment of choice. This was accomplished in this case with excellent results. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197505000-00033
更新日期:1975-05-01 00:00:00
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journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199101000-00013
更新日期:1991-01-01 00:00:00
abstract::Safety restraints have proven effective in the prevention of serious automobile injuries and deaths, but safety education has been ineffective in getting consumers to use restraints. We surveyed the personal and counseling practices of a group of pediatricians over a one-year period to determine whether prenatal and p...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198110000-00003
更新日期:1981-10-01 00:00:00
abstract::We discuss the cases of four immigrant workers in whom lead intoxication developed via inhalation while they were cutting steel beams removed from a dismantled bridge. They all had toxic lead levels with symptoms and received chelation therapy; the therapy was followed by a decrease in blood lead levels. Rebound incre...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199407000-00003
更新日期:1994-07-01 00:00:00
abstract::Children with sickle cell anemia who were less than 5 years old were observed over a three-year period. Those born to recent Haitian immigrants accounted for 108.4 patient-years. They had seven episodes of Streptococcus pneumoniae bacteremia and five due to Haemophilus influenzae for rates of 6.5 and 4.6 episodes per ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198907000-00009
更新日期:1989-07-01 00:00:00
abstract::We report four cases of group A streptococcal vulvovaginitis in prepubertal children. All cases were acute in onset. This illness presents with nonspecific signs and symptoms of labial inflammation. In a suburban community, streptococcal vulvovaginitis in prepubescent girls may be more common then genital infections d...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198204000-00017
更新日期:1982-04-01 00:00:00