Prevalence and significance of decreased bone density in pulmonary arterial hypertension.

Abstract:

OBJECTIVE:Decreased bone mineral density has been found in the advanced stages of various lung diseases. Limited data are available about prevalence and risk factors for osteoporosis/osteopenia (OP) in pulmonary arterial hypertension (PAH). METHODS:Patients with PAH (either idiopathic or secondary to scleroderma [SSC-PAH]) who underwent bone density testing for lung transplant evaluation were included. Results of bone density testing, demographic data, pulmonary function testing, hemodynamic measures, and 6-minute walk distance test (6MWD) were collected. RESULTS:Thirty-two patients were identified (27 women/5 men, 24 idiopathic PAH/8 SSC-PAH) and OP was found in 22 (69%) patients. Patients with SSC-PAH had more significant indications of OP at all of the measured sites. The OP group had lower FEV1 (P = 0.01) and a significantly lower 6MWD (P = 0.04) as compared with patients with PAH with normal bone density. Hemodynamics indicated no statistically significant differences between the groups other than a lower mean pulmonary artery pressure (P = 0.01) in the OP group. Patients with a history of corticosteroid use and smoking, postmenopausal status, decreased functional capacity (as measured by poor New York Heart Association functional class and 6MWD), SSC-PAH, and need for oxygen during a 6MWD test had an increased risk of OP by univariate logistic regression. CONCLUSIONS:Reduced bone density can be seen in a majority of patients with advanced PAH. Risk factors for reduced bone density include SSC-PAH, reduced 6MWD, need for oxygen during 6MWD testing, reduced FEV1, a history of smoking or corticosteroid use, and postmenopausal status.

journal_name

South Med J

journal_title

Southern medical journal

authors

Malik N,McCarthy K,Minai OA

doi

10.1097/SMJ.0b013e31825b8117

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

344-9

issue

7

eissn

0038-4348

issn

1541-8243

pii

00007611-201207000-00005

journal_volume

105

pub_type

杂志文章
  • Superiority of amniotic fluid index over amniotic fluid pocket measurement for predicting bad fetal outcome.

    abstract::Semiquantitative amniotic fluid volume (AFV) determination is a component of the fetal biophysical profile (BPP). To assess decreased AVF we did BPPs of 174 fetuses within 1 week of delivery. Two methods were used: measurement of the single largest vertical pocket (oligohydramnios = depth < 1 cm) and the four-quadrant...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-199304000-00011

    authors: Youssef AA,Abdulla SA,Sayed EH,Salem HT,Abdelalim AM,Devoe LD

    更新日期:1993-04-01 00:00:00

  • Neurologic abnormalities in a patient with human ehrlichiosis.

    abstract::Human ehrlichiosis is a tick-borne rickettsial disease characterized by fever, headache, myalgias, anorexia, and occasionally rash. In our patient, changes in mental status, upper motor neuron signs, cerebrospinal fluid pleocytosis, and increased serum protein levels were found in association with serologically confir...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-199011000-00031

    authors: Harkess JR,Stucky D,Ewing SA

    更新日期:1990-11-01 00:00:00

  • Surgery in head and neck lymphomas.

    abstract::Radiation therapy and/or chemotherapy are the treatment modalities of choice in lymphomas. Except for Burkitt's tumor, surgery is usually indicated only when percutaneous biopsy fails to establish the histologic diagnosis. We have described a patient with glomerulonephritis and anasarca secondary to an IgM-producing p...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198211000-00030

    authors: Osguthorpe JD,Rice D,Adkins WY

    更新日期:1982-11-01 00:00:00

  • Septicemia in children with cancer.

    abstract::Because of the persistently high mortality from sepsis in cancer patients, a retrospective study was designed to identify the causative organisms and to determine the factors affecting the outcome of sepsis. A total of 84 episodes of septicemia in 61 children with cancer were studied. The more frequently isolated orga...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-197902000-00007

    authors: Favor LF,Tarpay M,Blackstock R

    更新日期:1979-02-01 00:00:00

  • Malaria primer for clinicians in the United States.

    abstract::Though low, the incidence of malaria in the United States is not insignificant and can be the source of infection in febrile travelers returning from endemic areas. Clinicians practicing in the United States must have a basic understanding of the malaria life cycle and its treatments to properly diagnose and treat thi...

    journal_title:Southern medical journal

    pub_type: 杂志文章,评审

    doi:10.1097/01.smj.0000189904.50838.eb

    authors: Bledsoe GH

    更新日期:2005-12-01 00:00:00

  • Spinal epidural hematoma causing cord compression after tissue plasminogen activator and heparin therapy.

    abstract::Bleeding is the most serious complication of thrombolytic therapy and limits its usefulness. We have reported a case of epidural hematoma, a rare occurrence after combined therapy with tissue plasminogen activator (TPA) and heparin. We emphasize that in patients treated with thrombolytic agents, any trauma may increas...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:

    authors: Krolick MA,Cintron GB

    更新日期:1991-05-01 00:00:00

  • Life-threatening complications of empiric ceftriaxone therapy for 'seronegative Lyme disease'.

    abstract::Lyme disease, now the most common tick-borne illness in the United States, has recently received much media attention, due in part to its potentially serious sequelae in untreated patients. Because a rare patient with late illness may lack antibodies to the etiologic agent, Borrelia burgdorferi, physicians may be temp...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-199110000-00024

    authors: Nadelman RB,Arlin Z,Wormser GP

    更新日期:1991-10-01 00:00:00

  • Cytogenetic studies in couples with recurrent pregnancy loss.

    abstract::We reviewed the results of lymphocyte karyotypes from 232 couples who had had two or more pregnancy losses (spontaneous abortions or stillbirths). Despite the use of strict criteria to correct for possible bias of ascertainment, 8% of these couples (19 of 232) had a chromosome abnormality. Six of these abnormalities w...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198812000-00014

    authors: Sider D,Wilson WG,Sudduth K,Atkin JF,Kelly TE

    更新日期:1988-12-01 00:00:00

  • Barrett's esophagus: a multifaceted condition.

    abstract::Five patients with Barrett's esophagus, each with a differing presentation, serve as the basis of this report. Hiatal hernia is noted to be frequently present in Barrett's esophagus, and the incidence of adenocarcinoma is thought to be distinctly increased. The condition is easily diagnosed by fiberoptic endoscopy and...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:

    authors: Burke EL,Mullen JT

    更新日期:1976-03-01 00:00:00

  • Necrotic arachnidism.

    abstract::Ten bites by Loxosceles reclusa, the North American brown recluse spider, are reported from South Carolina. Envenomation by the brown recluse spider is becoming a public health problem in the United States. The spider reportedly now is found from coast to coast in the southern half of the country and its range is prob...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-197607000-00024

    authors: Majeski JA,Durst GG Sr

    更新日期:1976-07-01 00:00:00

  • Pulmonary contusion in children: diagnosis and management.

    abstract:BACKGROUND:Pulmonary contusion (PC) is the most common injury identified in pediatric blunt chest trauma. The disagreement over management principles of children with PC may complicate care of these patients. METHODS:We reviewed the literature and our institutional experience. RESULTS:Pulmonary contusion is most ofte...

    journal_title:Southern medical journal

    pub_type: 杂志文章,评审

    doi:10.1097/00007611-199812000-00002

    authors: Allen GS,Cox CS Jr

    更新日期:1998-12-01 00:00:00

  • Excessive fetal activity: another worrisome sign?

    abstract::Documented fetal inactivity is strongly suggestive of fetal jeopardy, but the significance of excessive activity over a prolonged period has not been reported. Using data gathered from fetal movement charts recorded by 931 patients, fetal hyperactivity was defined statistically as 40 or more movements perceived per ho...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198302000-00005

    authors: Rayburn WF,Rayburn PR,Gabel LL

    更新日期:1983-02-01 00:00:00

  • Synergistic effects of psyllium in the dietary treatment of hypercholesterolemia.

    abstract::We investigated psyllium fiber supplementation as a means of enhancing the cholesterol-lowering effect of the phase I American Heart Association diet. Fifty-nine subjects with total serum cholesterol (TC) levels ranging from 5.56 to 10.24 mmol/L (215 to 396 mg/dL) were given a 2-month dietary lead-in followed by 3 mon...

    journal_title:Southern medical journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00007611-199010000-00005

    authors: Neal GW,Balm TK

    更新日期:1990-10-01 00:00:00

  • House Staff Participation in Patient Safety Reporting: Identification of Predominant Barriers and Implementation of a Pilot Program.

    abstract:OBJECTIVES:Patient safety event (PSE) reporting is a critical element for healthcare organizations that are striving for continuous quality improvement. Although resident physicians routinely provide the majority of direct patient care, the level of their participation in PSE reporting historically has been low. In add...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.14423/SMJ.0000000000000486

    authors: Stewart DA,Junn J,Adams MA,Spencer-Segal JL,Perdoncin E,Lopez K,Kim CS

    更新日期:2016-07-01 00:00:00

  • Attitudes of internal medicine physicians toward type 2 diabetes.

    abstract:BACKGROUND:This study was designed to identify differences among internists in their attitudes about diabetes and how those attitudes influence practice behavior. METHODS:A cross-sectional study of 55 internists in an academic medical center was done using the Diabetes Attitude Scale (DAS-3), a valid and reliable meas...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:

    authors: Egede LE,Michel Y

    更新日期:2002-01-01 00:00:00

  • Miliary tuberculosis and consumption of clotting factors by multifocal vasculopathic coagulation.

    abstract::We have reported a third case of miliary tuberculosis and associated consumption coagulopathy. It is proposed that clotting factors may be locally consumed, thus producing the syndrome of "multifocal vasculopathic coagulation." ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-197911000-00042

    authors: Krauss JS,Walker DH

    更新日期:1979-11-01 00:00:00

  • Transient golden appendicolith.

    abstract::This case report describes an accidental ingestion of a gold dental inlay prosthesis that became lodged in the appendix. A nonsurgical approach was pursued because this blunt foreign body posed a minimal perforation risk. A second opinion for an elective appendectomy was chosen by the patient until a preoperative abdo...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-199807000-00012

    authors: Palmer GM,Shortsleeve MJ

    更新日期:1998-07-01 00:00:00

  • Primary carcinoma of the fallopian tube.

    abstract::Carcinoma of the fallopian tube is the least common of the gynecologic malignancies. Because of its rarity and the absence of typical symptoms, preoperative diagnosis is seldom made. Patient as well as physician delay in diagnosis is often considerable. There are no reliable laboratory aids available to enhance the di...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-197509000-00021

    authors: Ingram FH,Hisley JC

    更新日期:1975-09-01 00:00:00

  • Systemic lupus erythematosus: unusual presentation with gastric polyps and vasculitis.

    abstract::A case of SLE with the unique association of gastric polyps and vasculitis is reported. Gastrointestinal symptoms, surgical indications, and complications of SLE with gastrointestinal involvement are reviewed. The unusual patterns of ileus or lupus peritonitis secondary to mesenteric vasculitis must be differentiated ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:

    authors: Morton RE,Miller AI,Kaplan R

    更新日期:1976-04-01 00:00:00

  • Cholesterol and the older adult.

    abstract::The National Cholesterol Education Program and physician/patient awareness of the risks of hypercholesterolemia have resulted in aggressive screening and treatment of elevated cholesterol levels. The "one size fits all" concept has been used as the criterion for intervention. However, this has been promulgated without...

    journal_title:Southern medical journal

    pub_type: 杂志文章,评审

    doi:10.1097/00007611-199310001-00003

    authors: Kaiser FE

    更新日期:1993-10-01 00:00:00

  • Sigmoid volvulus in childhood.

    abstract::Although it is common in the adult population, sigmoid volvulus is unusual in childhood. We report the cases of four children treated for sigmoid volvulus, and we review an additional 44 cases. The mean age of occurrence was 8 years. Predisposing factors were present in 33%. Abdominal pain (66%), vomiting (31%), and o...

    journal_title:Southern medical journal

    pub_type: 杂志文章,评审

    doi:10.1097/00007611-199007000-00015

    authors: Smith SD,Golladay ES,Wagner C,Seibert JJ

    更新日期:1990-07-01 00:00:00

  • Interstitial cystitis and the potential role of gabapentin.

    abstract::Gabapentin, an antiepileptic agent, is a safe and versatile medication also used in the adjunctive treatment of painful disorders. These include neuropathic pain, such as postherpetic neuralgia, diabetic neuropathy, and the pain of reflex sympathetic dystrophy. Interstitial cystitis, a painful disease entity, shares m...

    journal_title:Southern medical journal

    pub_type: 杂志文章,评审

    doi:

    authors: Hansen HC

    更新日期:2000-02-01 00:00:00

  • Hepatitis C infection: a clinical review.

    abstract::Nearly three million persons in the United States are viremic with hepatitis C (HCV). Despite a decreasing incidence of HCV in this country, the prevalence of HCV-related chronic liver disease is increasing. Most infections in the United States are acquired by intravenous drug use. The chronicity rate of HCV is high, ...

    journal_title:Southern medical journal

    pub_type: 杂志文章,评审

    doi:10.1097/01.SMJ.0000118903.35704.30

    authors: Pearlman BL

    更新日期:2004-04-01 00:00:00

  • Psorospermium haeckelii: a cause of pseudoparasitosis.

    abstract::A 42-year-old man had nausea, vomiting, periumbilical pain, tenesmus, and diarrhea shortly after eating seafood. Stool microscopy showed "beaver bodies," or Psorospermium haeckelii, a nonpathogenic algal organism often confused with enteric pathogens and commonly found in the excrement of persons consuming crayfish. ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:

    authors: Bouckenooghe AR,Marino BJ

    更新日期:2001-02-01 00:00:00

  • Renocolic fistula.

    abstract::A case of left renocolic fistula secondary to chronic pyonephrosis has been reported. Neprectomy, excision of the fistulous tract, and closure of the colon is the treatment of choice. This was accomplished in this case with excellent results. ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-197505000-00033

    authors: Vargas AD,Victor I

    更新日期:1975-05-01 00:00:00

  • Roentgenographic evaluation of the augmented breast.

    abstract::We performed a retrospective study to determine the sensitivity of mammography in detecting breast cancer arising in women with augmented breasts. Of eight women with breast implants in whom breast cancer developed, six had mammograms before biopsy. Only two of the six cancers were identified mammographically (sensiti...

    journal_title:Southern medical journal

    pub_type: 杂志文章,评审

    doi:10.1097/00007611-199101000-00013

    authors: Douglas KP,Bluth EI,Sauter ER,McKinnon WM,Bergeron RB,Merritt CR,Sullivan MA,Finley JM

    更新日期:1991-01-01 00:00:00

  • Seat belt use and automobile safety counseling by pediatricians.

    abstract::Safety restraints have proven effective in the prevention of serious automobile injuries and deaths, but safety education has been ineffective in getting consumers to use restraints. We surveyed the personal and counseling practices of a group of pediatricians over a one-year period to determine whether prenatal and p...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198110000-00003

    authors: Greenberg LW,Coleman AB

    更新日期:1981-10-01 00:00:00

  • Occupational lead intoxication: report of four cases.

    abstract::We discuss the cases of four immigrant workers in whom lead intoxication developed via inhalation while they were cutting steel beams removed from a dismantled bridge. They all had toxic lead levels with symptoms and received chelation therapy; the therapy was followed by a decrease in blood lead levels. Rebound incre...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-199407000-00003

    authors: Grimsley EW,Adams-Mount L

    更新日期:1994-07-01 00:00:00

  • Increased incidence of bacteremia in Haitian children with sickle cell anemia.

    abstract::Children with sickle cell anemia who were less than 5 years old were observed over a three-year period. Those born to recent Haitian immigrants accounted for 108.4 patient-years. They had seven episodes of Streptococcus pneumoniae bacteremia and five due to Haemophilus influenzae for rates of 6.5 and 4.6 episodes per ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198907000-00009

    authors: Pegelow CH

    更新日期:1989-07-01 00:00:00

  • Vulvovaginitis in prepubertal girls: the importance of group A Streptococcus.

    abstract::We report four cases of group A streptococcal vulvovaginitis in prepubertal children. All cases were acute in onset. This illness presents with nonspecific signs and symptoms of labial inflammation. In a suburban community, streptococcal vulvovaginitis in prepubescent girls may be more common then genital infections d...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198204000-00017

    authors: Schwartz RH,Wientzen RL,Barsanti RG

    更新日期:1982-04-01 00:00:00