Synergistic effects of psyllium in the dietary treatment of hypercholesterolemia.

Abstract:

:We investigated psyllium fiber supplementation as a means of enhancing the cholesterol-lowering effect of the phase I American Heart Association diet. Fifty-nine subjects with total serum cholesterol (TC) levels ranging from 5.56 to 10.24 mmol/L (215 to 396 mg/dL) were given a 2-month dietary lead-in followed by 3 months of diet only (29 subjects) or diet supplemented with 20.4 g of psyllium daily (30 subjects). Unlike women, men had a significant decrease in levels of both TC (-8.0%) and low-density lipoprotein cholesterol (LDL-C) (-10.1%) during the dietary lead-in. Psyllium supplementation resulted in an additional 5.5% reduction in the TC levels as compared to diet alone. Psyllium supplementation combined with dietary lead-in resulted in an overall 17.3% decrease in the TC and a 20.0% decrease in LDL-C for men, with decreases of 7.7% and 11.6%, respectively, for women. Psyllium effectively enhances the cholesterol-lowering effect of the phase I diet.

journal_name

South Med J

journal_title

Southern medical journal

authors

Neal GW,Balm TK

doi

10.1097/00007611-199010000-00005

subject

Has Abstract

pub_date

1990-10-01 00:00:00

pages

1131-7

issue

10

eissn

0038-4348

issn

1541-8243

journal_volume

83

pub_type

临床试验,杂志文章,随机对照试验
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