Abstract:
:Cyclosporine is a fungal metabolite increasingly used as an immunosuppressive agent in organ transplantation. It provides immunosuppression primarily through reversible inhibition of T-lymphocytes, without myelotoxicity. Cyclosporine appears to inhibit primary activation of helper cells and to decrease the production of lymphokines by these cells. Cyclosporine becomes widely distributed into tissue compartments and is metabolized primarily by the liver. Serum trough levels, measured by radioimmunoassay or high pressure liquid chromatography, are commonly monitored and sometimes used for dose adjustments. Cyclosporine has been used in human renal, cardiac, liver, bone marrow, and pancreatic transplantation, as well as in other experimental animal models. It has a narrow therapeutic index, with major complications arising from nephrotoxicity, hypertension, and hepatotoxicity. Cyclosporine also has some antischistosomal and antimalarial activity.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Thomas SE,Gordon DSdoi
10.1097/00007611-198602000-00017subject
Has Abstractpub_date
1986-02-01 00:00:00pages
205-14issue
2eissn
0038-4348issn
1541-8243journal_volume
79pub_type
杂志文章,评审abstract:OBJECTIVES:Program directors have noted that first-year residents struggle with many of the patient care responsibilities they assume as they enter the US graduate medical education system. A national description of medical students' patient care experience in advance of graduation has not been published. We sought to ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000738
更新日期:2017-12-01 00:00:00
abstract::A patient with stable non-insulin-dependent diabetes mellitus had five successive cranial nerve palsies, all of which resolved. This syndrome is rarely encountered in patients with diabetes and in otherwise healthy individuals. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198502000-00027
更新日期:1985-02-01 00:00:00
abstract::Inhalation abuse of volatile solvents, previously known generically as "glue sniffing," is typically pursued by adolescents. A wide range of legal, easily obtained products containing volatile substances are available for abuse. We report two illustrative cases of fatal volatile substance abuse: gasoline sniffing in a...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:The number of methicillin-resistant STaphylococcus aureus (MRSA) infections in the hospital setting is increasing but little is known of its prevalence in the community. In a 1986-1987 study, the prevalence in dermatology outpatient clinics was <0.9%. This study reports changes in the same facilities from 19...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199804000-00011
更新日期:1998-04-01 00:00:00
abstract::We reviewed the records of 101 patients over the age of 60 who had exploration and cholecystectomy in 1982 at Norfolk General Hospital. There were 52 elective and 49 emergency cases. Women comprised 57.4% of the patients, and almost 50% of the patients were over the age of 70. Forty-nine percent of the cases were emer...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198704000-00016
更新日期:1987-04-01 00:00:00
abstract::Two new cases of Menetrier's disease in children are reported. The ten cases of this protein-losing gastropathy previously reported in the literature are reviewed. Clinical presentations, laboratory findings, possible causes, and comparison with the adult form of Menetrier's disease are discussed. Menetrier's disease ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197901000-00011
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVES:Transcranial Doppler ultrasound (TCD) effectively identifies children with sickle cell anemia (SCA) who are at increased risk of stroke. We evaluated a low-cost quality improvement (QI) intervention to increase the proportion of children screened by TCD. METHODS:We measured the proportion of children with S...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章
doi:10.14423/SMJ.0000000000000517
更新日期:2016-09-01 00:00:00
abstract::Hyperfunctioning thyroid nodule was diagnosed in a 72-year-old woman. When the nodule reached a diameter of 3.5 cm, overt thyrotoxicosis of the apathetic type was precipitated by hemorrhage into the nodule during a period of excessive anticoagulation. All abnormal physical signs and symptoms as well as laboratory find...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198505000-00024
更新日期:1985-05-01 00:00:00
abstract::Increasingly the courts are expanding the scope of viable causes of action and the nature of damages, as well as the spectrum of plaintiffs to include the unborn. Generally the courts accept medically established standards of care, but on occasion courts create the standard of care. Predicated on this type of scenario...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1980-10-01 00:00:00
abstract:BACKGROUND:Conventional magnetic resonance imaging (MRI) of complex cervical spine disorders may underestimate the magnitude of structural disease because imaging is performed in a nondynamic non-weight-bearing manner. Myelography provides additional information but requires an invasive procedure. METHODS:This was a p...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章
doi:10.1097/00007611-200405000-00008
更新日期:2004-05-01 00:00:00
abstract::The demented patient requires medical and often psychiatric supervision, but the caregiver is often neglected. This article identifies special issues for caregivers that may need attention from the demented patient's physician. The physician's attention can benefit both the patient and the caregiver and save the physi...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract::In a series of 565 morbidly obese patients having one of five gastric bariatric procedures done at North Carolina Memorial Hospital between May 1975 and December 1982, 55 patients had 58 complications requiring reoperation. These complications included a leak from the stomach or anastomosis, stomal obstruction, and su...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198505000-00009
更新日期:1985-05-01 00:00:00
abstract::Allergic rhinitis affects approximately 40% of children and generally presents in children from 10-19 years of age; however, the condition has been seen in children as young as 6 months. Antihistamines are commonly prescribed in infants and children for the relief of allergic symptoms. A 23-month-old male with a histo...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181b9ae49
更新日期:2010-05-01 00:00:00
abstract::Of five patients with hypernephroma who were maintained on hemodialysis after nephrectomy, four died with metastic disease after having been on hemodialysis for an average of 13.7 months (range 8 to 19). The fifth patient had no evidence of malignancy after 21 months of dialysis; he then received a renal allograft fro...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197908000-00019
更新日期:1979-08-01 00:00:00
abstract:OBJECTIVES:Improving diabetes and blood pressure control decreases the incidence and progression of microvascular disease. Likewise, screening for microvascular complications is beneficial in the early detection and treatment of these disorders. However, adherence to practice guidelines for screening and treatment in p...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000140853.71806.31
更新日期:2004-11-01 00:00:00
abstract::Stroke is a treatable disease. Despite the therapeutic nihilism of the past, the advent of thrombolysis has changed the way stroke is approached. Acute ischemic stroke is a challenging and heterogeneous disease. Treatment needs to be based on an understanding of the underlying pathophysiology of ischemia. Intervention...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/01.SMJ.0000063573.56033.A6
更新日期:2003-04-01 00:00:00
abstract::An unusual volar and radial perilunate transscaphoid fracture dislocation is reported. Treatment of perilunate transscaphoid fracture dislocations by closed reduction often produces a poor result. Early open reduction may be followed by a good result, but if open reduction is impossible, proximal row carpectomy is adv...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197507000-00025
更新日期:1975-07-01 00:00:00
abstract::In a prospective study of the etiology of pneumonia in patients hospitalized at a university hospital, all respiratory secretions were tested for routine pathogens as well as Legionella. A diagnosis was established in 60 of 87 patients studied. Of the 37 nosocomial infections, six were caused by L micdadei. Gram-negat...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198604000-00007
更新日期:1986-04-01 00:00:00
abstract::Whipple disease (WD) is a rare disease caused by Tropheryma whipplei. The classic profile of the patient is that of a middle-aged man presenting with fever, chronic diarrhea, and arthralgias. Extragastrointestinal manifestations are not rare. A high degree of clinical suspicion for the disease is needed in atypical ca...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181d3949c
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Hyponatremia is a frequent condition in elderly patients. In diagnostic workup, a 24-hour urine sample is used to measure urinary osmolality and urinary sodium concentration necessary to confirm the diagnosis of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). This study was undertake...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e31819b0e06
更新日期:2009-04-01 00:00:00
abstract::Thirty-two cases of gonococcal arthritis in pregnant women admitted to Jackson Memorial Hospital between 1962 and 1971 are reviewed. Our specific aim is to reinforce awareness of this serious complication in pregnancy. The incidence of gonococcal arthritis is higher in women, but more significantly, it appears that th...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197511000-00004
更新日期:1975-11-01 00:00:00
abstract::A patient was referred for evaluation of obstructive uropathy after treatment with 10% formalin to control recurrent hemorrhagic radiation cystitis. Progressive bilateral ureteral, pelvic, and renal parenchymal destruction occurred despite ileal ureteral replacement. This complication of therapy reinforces the concept...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197809000-00029
更新日期:1978-09-01 00:00:00
abstract::Carcinoma of the colon occurring to the right of the middle colic vessels is usually described as morphologically and clinically distinctive from cancers occurring in the left colon. Cancers of the right colon are characterized as polypoid tumors that are discovered in the search for occult blood loss, whereas carcino...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198112000-00005
更新日期:1981-12-01 00:00:00
abstract::I describe the case of a 25-year-old man who, after a scuba dive, had ocular barotrauma caused by mask squeeze. As in most cases, the condition occurred because the patient failed to exhale into the mask during descent to equalize the pressure within the mask. Although alarming in appearance, the condition is generall...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199407000-00015
更新日期:1994-07-01 00:00:00
abstract::A 51-year-old woman suffered from dyspnea for several days before she came to an outside clinic for help. Pleura biopsy was performed and the histologic diagnosis was malignant mesothelioma. Sixteen months later, a palpable left breast lump was noted. Physical examination revealed a firm mass in the breast, measuring ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.smj.0000251471.99684.9f
更新日期:2006-12-01 00:00:00
abstract::Restorative proctocolectomy with ileal pouch anal anastomosis has become the most commonly used procedure for elective treatment of patients with mucosal ulcerative colitis and familial adenomatous polyposis. Since its original description, the procedure has been modified in an attempt to obtain optimal functional res...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/01.SMJ.0000047720.97917.03
更新日期:2003-01-01 00:00:00
abstract::The study goals were to document the incidence of elevated blood pressure (BP) values in public high school students in Tulsa, Oklahoma; to determine whether age and sex are risk factors; and to encourage adolescents with abnormal screening BP values to seek medical care. Over a 2-year period, 5537 adolescents aged 14...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199205000-00007
更新日期:1992-05-01 00:00:00
abstract::This study was undertaken to determine what factors would be useful in making a decision to do bronchoscopy to look for an obstructing carcinoma in cases of pneumonia. The study showed that in pneumonia limited to one lobe of the lung, which occurs in a heavy smoker over 50 years of age, and which does not have comple...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198006000-00024
更新日期:1980-06-01 00:00:00
abstract::Ninety-four children with typhoid fever presented with the primary complaints of fever, diarrhea, and vomiting. Fifty-two percent had hepatomegaly and derangements of SGOT and LDH. None developed hepatic decompensation and all had rapid clinical recovery. The abnormal liver function test served no prognostic purpose. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197607000-00037
更新日期:1976-07-01 00:00:00
abstract:OBJECTIVES:Patients awaiting heart transplantation can be listed for prolonged periods of time and, as a result, the prevalence of anxiety and depression is high. Our study evaluates the feasibility of canine-assisted therapy (CAT) in this population. METHODS:A prospective, multicenter study was performed on all statu...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000980
更新日期:2019-06-01 00:00:00