Cyclosporine.

Abstract:

:Cyclosporine is a fungal metabolite increasingly used as an immunosuppressive agent in organ transplantation. It provides immunosuppression primarily through reversible inhibition of T-lymphocytes, without myelotoxicity. Cyclosporine appears to inhibit primary activation of helper cells and to decrease the production of lymphokines by these cells. Cyclosporine becomes widely distributed into tissue compartments and is metabolized primarily by the liver. Serum trough levels, measured by radioimmunoassay or high pressure liquid chromatography, are commonly monitored and sometimes used for dose adjustments. Cyclosporine has been used in human renal, cardiac, liver, bone marrow, and pancreatic transplantation, as well as in other experimental animal models. It has a narrow therapeutic index, with major complications arising from nephrotoxicity, hypertension, and hepatotoxicity. Cyclosporine also has some antischistosomal and antimalarial activity.

journal_name

South Med J

journal_title

Southern medical journal

authors

Thomas SE,Gordon DS

doi

10.1097/00007611-198602000-00017

subject

Has Abstract

pub_date

1986-02-01 00:00:00

pages

205-14

issue

2

eissn

0038-4348

issn

1541-8243

journal_volume

79

pub_type

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