Whipple disease.

Abstract:

:Whipple disease (WD) is a rare disease caused by Tropheryma whipplei. The classic profile of the patient is that of a middle-aged man presenting with fever, chronic diarrhea, and arthralgias. Extragastrointestinal manifestations are not rare. A high degree of clinical suspicion for the disease is needed in atypical cases. Trimethoprim-sulfamethoxazole is the treatment of choice. We present two patients with WD. The first presented with melena and generalized hyperpigmentation. The second had depression for two years before the typical symptoms. Both hyperpigmentation and long-lasting depression without the typical manifestations of the disease are rare. Histologic examination of tissue biopsies was diagnostic for WD. Both patients were treated successfully with trimethoprim-sulfamethoxazole.

journal_name

South Med J

journal_title

Southern medical journal

authors

Basagiannis CS,Panagoulias GS,Tentolouris N,Basoukeas S,Sambaziotis D,Ladas SD

doi

10.1097/SMJ.0b013e3181d3949c

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

353-6

issue

4

eissn

0038-4348

issn

1541-8243

journal_volume

103

pub_type

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