Invasive group A streptococcal infections in Florida.

Abstract:

BACKGROUND:Several previous studies of invasive Group A streptococcal (GAS) disease have been hindered by small sample sizes (< or = 100 patients) and limited generalizability. METHODS:We conducted a population-based study of invasive GAS disease. The objectives of the study were to describe the clinical features of individuals who were hospitalized for invasive GAS disease and to identify risk factors for hospital mortality. The cases were 257 patients who were hospitalized throughout Florida during a 4-year period and reported to the Florida Department of Health. Logistic regression was used to calculate adjusted odds ratios (OR) for mortality and 95% confidence intervals (CI). RESULTS:The overall mortality was 18% (41 of 228). Admission into an intensive care unit was a strong predictor of mortality (OR, 20.41; 95% CI, 6.41-64.96). Treatment with clindamycin reduced mortality in patients who had necrotizing fasciitis (OR, 0.11; 95% CI, 0.01-0.89) but not in patients who did not have necrotizing fasciitis (OR, 1.01; 95% CI, 0.31-3.33). CONCLUSION:Clindamycin reduces mortality in patients with invasive GAS disease who have necrotizing fasciitis.

journal_name

South Med J

journal_title

Southern medical journal

authors

Mulla ZD,Leaverton PE,Wiersma ST

doi

10.1097/01.SMJ.0000051060.95210.9A

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

968-73

issue

10

eissn

0038-4348

issn

1541-8243

journal_volume

96

pub_type

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