Assessment of therapeutic plasmapheresis in demyelinating neurologic disorders.

Abstract:

:Considerable controversy exists with regard to therapeutic efficacy of plasmapheresis in the immune-mediated demyelinating disorders of the peripheral and central nervous system: acute inflammatory polyneuropathy (Guillain-Barré syndrome), chronic inflammatory demyelinating polyneuropathy, and multiple sclerosis. In an effort to establish specific situations where plasmapheresis was of therapeutic value, we reviewed the experience at Southwestern Medical School, University of Texas Health Science Center at Dallas, and that published in the literature. In acute inflammatory demyelinating polyneuropathy (Guillain-Barré syndrome), plasmapheresis may prevent progression of the illness, and it significantly increases the rate of recovery. For patients with chronic inflammatory polyneuropathy, plasmapheresis has produced clinical improvement in 50% of corticosteroid-refractory patients. The use of plasmapheresis in patients with acute or chronic progressive multiple sclerosis still remains controversial.

journal_name

South Med J

journal_title

Southern medical journal

authors

Tindall RS,Rollins JA

doi

10.1097/00007611-198608000-00018

subject

Has Abstract

pub_date

1986-08-01 00:00:00

pages

991-7

issue

8

eissn

0038-4348

issn

1541-8243

journal_volume

79

pub_type

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