Abstract:
:A phase II study of doxorubicin (Adriamycin)-based induction chemotherapy followed by cyclophosphamide/BCNU (CyBCNU) intensification and autologous bone marrow transplantation (ABMT) was conducted in 20 consecutive women with hormone-resistant metastatic breast cancer referred to our center. Of these 20 women, aged 24 to 56 (median age, 41), 9 had complete remission and 11 had partial remission after induction chemotherapy. Predominant sites of metastases included liver (5), lung (4), bone/bone marrow (5), and soft tissue (6). The dose of cyclophosphamide was 160 mg/kg and the dose of BCNU, 600 mg/m2, followed by infusion of a mean 2.30 x 10(8) nucleated marrow cells per kilogram of body weight. All patients achieved durable engraftment. Three patients remain disease-free at 62+, 67+, and 73+ months; two of these were in complete remission before ABMT. Actual relapse-free survival at 5 years is 15% and median survival from ABMT is 17 months. Induction chemotherapy followed by CyBCNU intensification in metastatic breast cancer can achieve prolonged relapse-free survival in 15% of patients, some of whom may be cured.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Saez RA,Slease RB,Selby GB,Strnad C,Epstein RB,Confer DLdoi
10.1097/00007611-199503000-00015subject
Has Abstractpub_date
1995-03-01 00:00:00pages
320-6issue
3eissn
0038-4348issn
1541-8243journal_volume
88pub_type
临床试验,杂志文章abstract::Phantom sensation and phantom limb pain are two recognized sequelae of limb amputation. In most previous surveys, amputations were done for arteriosclerotic or trauma related conditions. We studied 25 patients who had lower extremity amputation for neoplasia. In studying the features of pain before and after amputatio...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198501000-00009
更新日期:1985-01-01 00:00:00
abstract::Depression is among the most common of clinical conditions. Like problems such as anemia, it is not one disease, but a constellation of signs and symptoms which may occur as the result of several psychopatho-physiologic processes. This paper summarizes the recent dramatic advances in research into the neurochemistry o...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197502000-00015
更新日期:1975-02-01 00:00:00
abstract::This article reviews the epidemiology of weight gain and diabetes mellitus in general and in patients with severe mental illness in particular. Body mass index is defined, and possible predictors for weight gain in patients receiving antipsychotic medications are also enumerated. Information on risk of association wit...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/01.smj.0000167621.49292.11
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:To compare mobile health (mHealth) usage by residents of West Virginia with national estimates. METHODS:Pew Research Center data from its Internet and American Life Project were accessed for secondary data analysis. These data, available to the public, are a probability sample of Internet use in the United S...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000879
更新日期:2018-10-01 00:00:00
abstract::A patient ingested a massive amount of an oral theophylline preparation and recovered. The paucity of central nervous system manifestations may have been related to the presence of fulminant diarrhea with expulsion of the tablets per rectum. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197808000-00027
更新日期:1978-08-01 00:00:00
abstract::Ruptured ovarian artery aneurysm is rare. Of the eight cases previously reported, seven were diagnosed postpartum. Our case of a ruptured right ovarian artery aneurysm was associated with massive retroperitoneal bleeding. The probable time of rupture could be traced to the second stage of labor. This case indicates th...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199309000-00023
更新日期:1993-09-01 00:00:00
abstract::We report a retrospective evaluation of the role of panretinal photocoagulation in the primary treatment of neovascular glaucoma. Thirty-six eyes (32 patients) received aggressive argon laser panretinal photocoagulation beginning as soon as feasible after diagnosis of the developing neovascular glaucoma. Thirty eyes w...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198811000-00008
更新日期:1988-11-01 00:00:00
abstract:OBJECTIVES:To explore factors that might contribute to misattribution of mental status changes to psychiatric illness when an elderly patient actually has a delirium (mental status changes due to a medical condition). METHODS:Records of 900 elderly patients referred to a Veterans Affairs psychiatric inpatient unit and...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181c99423
更新日期:2010-02-01 00:00:00
abstract::Two siblings had frequent seizures from the second and third day of life until one week and seven months, respectively. The mother, grandmothers, and three other family members were similarly affected. Known causes of neonatal seizures were excluded. The condition is inherited as an autosomal dominant trait. Its etiol...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198205000-00038
更新日期:1982-05-01 00:00:00
abstract:OBJECTIVES:To evaluate the statewide experience in mode of delivery for pregnancies complicated by stillbirth by annual delivery volume and presence of graduate medical education programs. METHODS:This is a descriptive study of all stillbirths without known congenital anomalies or aneuploidy born in our state from Jul...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000001180
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Among patients with pulmonary disease due to Mycobacterium avium complex (MAC) seen recently at our center, a substantial number have had extensive calcified mediastinal, hilar, and peribronchial lymphadenopathy, a finding historically inconsistent with pulmonary MAC disease. METHOD:We retrospectively studi...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199906000-00005
更新日期:1999-06-01 00:00:00
abstract::A 54-year-old woman, perhaps the oldest living American black with homozygous beta thalassemia, has had a relatively benign clinical course since her case was first reported two decades ago. Despite progressive splenomegaly, she has remained active without blood transfusions. This case emphasizes the mildness of homoz...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197609000-00041
更新日期:1976-09-01 00:00:00
abstract::Six patients characterized by psychopathic behavior were treated with lesions placed in the center median nucleus of the thalamus. There was marked improvement of the psychopathic behavior in five patients. One patient with unilateral thalamotomy was parqially improved. Four of the six patients have been productive an...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197504000-00013
更新日期:1975-04-01 00:00:00
abstract::While fish consumption is considered a component of a heart-healthy diet, many illnesses have been associated with eating contaminated fish. The authors describe two cases of muscle weakness and rhabdomyolysis that occurred after eating salmon. Cases of rhabdomyolysis and muscle weakness after consumption of fresh wat...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181583673
更新日期:2007-11-01 00:00:00
abstract::A resurgence of acute rheumatic fever (ARF) has been reported in many areas of the United States in recent years. We retrospectively reviewed the medical records of inpatients with a new diagnosis of ARF from 1982 through 1988 at a children's hospital that serves a six-state referral area in the mid-South. Thirty pati...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199012000-00012
更新日期:1990-12-01 00:00:00
abstract::The results of radiation therapy of 79 patients with early carcinoma of the vocal cord are reported. Nine (13%) of the 69 patients with stage I disease had local recurrence, and two (20%) of the ten patients with stage II disease had local recurrence without local node metastasis. Subsequent control of radiation failu...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197901000-00004
更新日期:1979-01-01 00:00:00
abstract::Bile drainage through normal lymphatic pathways has been described, but bile drainage from the liver to the duodenum via lymphatic collaterals has not. We have described a patient with a common bile duct stricture and lymphatic drainage of bile into the duodenum. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198401000-00028
更新日期:1984-01-01 00:00:00
abstract::Between October 1977 and 1978, 93 CutterCast casts were applied at the Veterans Administration Hospital in Atlanta, Georgia. The composition and application of this new casting system are described, and the performance of the 93 casts is evaluated in relation to ease of application, roentgenographic clarity, skin cond...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198005000-00007
更新日期:1980-05-01 00:00:00
abstract::Cobalamin (vitamin B12) deficiency warrants appropriate evaluation because cobalamin is necessary in certain biochemical functions. R-binder deficiency, which causes low cobalamin levels, is a rare and benign pseudodeficiency. If not further evaluated by determining levels of methylmalonic acid and homocysteine, howev...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2002-09-01 00:00:00
abstract::Multiple sclerosis (MS) is among the most crippling diseases of the nervous system in young adults, and diagnosis can be difficult. It is true that MS can exist without magnetic resonance imaging or cerebrospinal fluid abnormalities, but whenever there are an atypical clinical pattern and no confirmatory laboratory te...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199603000-00008
更新日期:1996-03-01 00:00:00
abstract::The diagnoses of complete obstruction in a duplicated renal collecting system and ureterocele can be made with a high degree of confidence by ultrasound. Two children presenting with abdominal masses were examined by gray scale ultrasonography which demonstrated large cystic masses dorsal to and displacing the lower p...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198008000-00018
更新日期:1980-08-01 00:00:00
abstract::To study the role of formula as a cause of rickets, we randomly assigned 46 very-low-birth-weight (VLBW) infants (less than or equal to 1,500 gm) to one of three groups receiving either Isomil, a soy isolate formula, Similac with Iron, a common milk-based formula, or Similac 24 LBW, a hypercaloric milk-based formula d...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章
doi:10.1097/00007611-198401000-00005
更新日期:1984-01-01 00:00:00
abstract::Buried bumper syndrome (BBS) is an uncommon complication of percutaneous endoscopic gastrostomy (PEG) tube placement. This unusual phenomenon occurs when the internal bumper of a PEG tube erodes and migrates through the gastric wall and becomes lodged anywhere between the gastric wall and the skin. If not removed and ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181fa73d0
更新日期:2010-12-01 00:00:00
abstract::Allergic rhinitis affects approximately 40% of children and generally presents in children from 10-19 years of age; however, the condition has been seen in children as young as 6 months. Antihistamines are commonly prescribed in infants and children for the relief of allergic symptoms. A 23-month-old male with a histo...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181b9ae49
更新日期:2010-05-01 00:00:00
abstract::This study was done to ascertain whether there was an increased incidence of acute rheumatic fever (ARF) in west Alabama, similar to that reported elsewhere within the United States. Hospital records for the previous 10 years were reviewed and 5-year intervals were compared (1980 through 1984 vs 1985 through 1989). A ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199203000-00007
更新日期:1992-03-01 00:00:00
abstract::A 66-year-old woman with a subacute onset of mild dementia and headaches was discovered to have multiple large, hyperdense lesions on cranial CT scan. Biopsy showed poorly differentiated adenocarcinoma with necrosis and dystrophic calcification, which represented an unusual initial manifestation of metastatic breast c...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198602000-00030
更新日期:1986-02-01 00:00:00
abstract::Two patients with retained laparotomy pads after laparotomy had pain, abscess formation, and bleeding, with erosion of the pad into the small bowel and colon. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198604000-00026
更新日期:1986-04-01 00:00:00
abstract::Ten bites by Loxosceles reclusa, the North American brown recluse spider, are reported from South Carolina. Envenomation by the brown recluse spider is becoming a public health problem in the United States. The spider reportedly now is found from coast to coast in the southern half of the country and its range is prob...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197607000-00024
更新日期:1976-07-01 00:00:00
abstract::The clinical course and long-term survival of a patient with acute disseminated histiocytosis X and extrahypothalamic CNS involement were presented. The clinical significance of histiocytes appearing in the CSF cocomitant with the onset of this neurologic syndrome was discussed. Detailed cytologic examination of the C...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1977-11-01 00:00:00
abstract::A unique case of Sheehan's syndrome is characterized by deficiencies of growth hormone, prolactin, thyrotropin, and ACTH. Clinically, it was manifested by adrenal and thyroid insufficiency with regular cyclical menses. Normal menstrual cycles do not preclude extensive hypothalamic-pituitary destruction. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198308000-00040
更新日期:1983-08-01 00:00:00