Long-term survival after autologous bone marrow transplantation for metastatic breast carcinoma.

Abstract:

:A phase II study of doxorubicin (Adriamycin)-based induction chemotherapy followed by cyclophosphamide/BCNU (CyBCNU) intensification and autologous bone marrow transplantation (ABMT) was conducted in 20 consecutive women with hormone-resistant metastatic breast cancer referred to our center. Of these 20 women, aged 24 to 56 (median age, 41), 9 had complete remission and 11 had partial remission after induction chemotherapy. Predominant sites of metastases included liver (5), lung (4), bone/bone marrow (5), and soft tissue (6). The dose of cyclophosphamide was 160 mg/kg and the dose of BCNU, 600 mg/m2, followed by infusion of a mean 2.30 x 10(8) nucleated marrow cells per kilogram of body weight. All patients achieved durable engraftment. Three patients remain disease-free at 62+, 67+, and 73+ months; two of these were in complete remission before ABMT. Actual relapse-free survival at 5 years is 15% and median survival from ABMT is 17 months. Induction chemotherapy followed by CyBCNU intensification in metastatic breast cancer can achieve prolonged relapse-free survival in 15% of patients, some of whom may be cured.

journal_name

South Med J

journal_title

Southern medical journal

authors

Saez RA,Slease RB,Selby GB,Strnad C,Epstein RB,Confer DL

doi

10.1097/00007611-199503000-00015

subject

Has Abstract

pub_date

1995-03-01 00:00:00

pages

320-6

issue

3

eissn

0038-4348

issn

1541-8243

journal_volume

88

pub_type

临床试验,杂志文章
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