Rickets in premature infants fed different formulas.

Abstract:

:To study the role of formula as a cause of rickets, we randomly assigned 46 very-low-birth-weight (VLBW) infants (less than or equal to 1,500 gm) to one of three groups receiving either Isomil, a soy isolate formula, Similac with Iron, a common milk-based formula, or Similac 24 LBW, a hypercaloric milk-based formula designed for low-birth-weight infants during the first three to four months of life. Postnatal changes in serum calcium, phosphorus, alkaline phosphatase, and albumin were monitored during this study. Radiologic diagnosis of rickets was made in 60% of infants fed Isomil and 5% fed Similac with Iron. Significantly low levels of serum phosphorus and high levels of serum alkaline phosphatase were also seen in infants fed Isomil. The exact cause of the biochemical changes and the high incidence of rickets among infants fed Isomil is not clear. Poor solubility and possibly the decreased bioavailability of minerals in soy isolate formula may be important. We conclude that rickets occurs with high frequency among VLBW infants fed soy isolate, but not milk-based formulas. We suggest that prolonged feeding of soy isolate formulas should be avoided in VLBW infants.

journal_name

South Med J

journal_title

Southern medical journal

authors

Kulkarni PB,Dorand RD,Bridger WM,Payne JH 3rd,Montiel DC,Hill JG

doi

10.1097/00007611-198401000-00005

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

13-6, 20

issue

1

eissn

0038-4348

issn

1541-8243

journal_volume

77

pub_type

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