Abstract:
:The renin-angiotensin-aldosterone system (RAAS) plays a major role in blood pressure regulation and is thus an important therapeutic target in the management of hypertension. Angiotensin receptor blockers (ARBs), which interrupt RAAS overactivity by blocking a specific receptor that mediates the pathogenic activity of angiotensin II, represent a major addition to the clinician's armamentarium for the management of hypertension. A solid body of clinical evidence demonstrates that ARBs are effective in the management of hypertension as monotherapy or in combination with other agents. Although comparable to angiotensin-converting enzyme inhibitors and other major classes of antihypertensive agents in the treatment of hypertension, the favorable tolerability profile of ARBs make them an attractive alternative for many patients. Recent evidence suggests that treatment persistence with ARB therapy during a 12-month period is typically higher than with other antihypertensive classes, a finding perhaps driven by fewer treatment-limiting side effects. The combination of clinical efficacy and tolerability should render ARBs as a major treatment alternative for hypertension.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Catanzaro DF,Frishman WHdoi
10.1097/SMJ.0b013e3181e1e2dasubject
Has Abstractpub_date
2010-07-01 00:00:00pages
669-73issue
7eissn
0038-4348issn
1541-8243journal_volume
103pub_type
杂志文章,评审abstract:OBJECTIVES:Noninvasive assessment of right heart function and hemodynamics in patients with pulmonary arterial hypertension (PAH) is most often performed at rest, whereas the symptoms, in general, present with exertion. Assessment during exertion is limited to symptom assessment and the 6-minute walk distance. We inves...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3182805165
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:: Bronchus-associated Lymphoid Tissue (BALT) lymphomas are a rare type of extranodal marginal zone lymphomas. They comprise 1% of lymphomas and more than two-thirds of all primary non-Hodgkin lymphoma (NHL) of the lung. BALT lymphomas arise from the bronchus-associated lymphoid tissue. METHODS:This report d...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181bfdd2d
更新日期:2009-12-01 00:00:00
abstract::Use of the needle-catheter feeding jejunostomy at Richland Memorial Hospital and the Dorn Veterans Administration Hospital, both clinical teaching institutions of the University of South Carolina School of Medicine, has been evaluated in 114 patients ranging from 20 to 90 years old. The results of this survey span a 3...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198611000-00018
更新日期:1986-11-01 00:00:00
abstract:OBJECTIVES:Pulmonary arterial hypertension (PAH) is a progressive disease that can be treated with several medications. Macitentan, an endothelin receptor antagonist (ERA), has received approval as a PAH therapy. We report our data regarding the tolerability in patients with PAH who were switched from bosentan to macit...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000607
更新日期:2017-03-01 00:00:00
abstract::Cirrhosis affects millions of people around the world and is associated with increased morbidity and mortality. Spontaneous bacterial peritonitis (SBP) is a common complication of liver disease with cirrhosis and accounts for up to 30% of infections in patients with cirrhosis. Patients with a history of SBP and those ...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.14423/SMJ.0000000000000887
更新日期:2018-11-01 00:00:00
abstract::Blastomyces dermatitidis, a dimorphic broad-based budding yeast endemic to the Mississippi River Valley region, is responsible for morbidity in humans via inhalation and dissemination. The response of acute lung injury, which produces an illness with serious morbidity and an approximately 50% mortality, uncommonly occ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199809000-00012
更新日期:1998-09-01 00:00:00
abstract::I reviewed 100 consecutive radiologic examinations with particular attention to the clinical information included. The referring physician originated this clinical information in only 33% of cases. Other personnel, including nurses and aides, added information on the requisitions 57% of the time. When nonphysician per...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1983-02-01 00:00:00
abstract::The risks of morbidity and mortality associated with transfusion are so great that no transfusion should be given until it is decided that it is absolutely necessary and then only with the utmost care. The unfavorable effects of transfusion reviewed are: hemolytic reaction; bacterial contamination; febrile reaction du...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1976-04-01 00:00:00
abstract::Septic arthritis is a serious and sometimes fatal complication of rheumatoid arthritis. We have examined the clinical characteristics of 16 patients with infectious arthritis seen during an eight-year period. This represented 0.5% of all admissions to our hospital for patients with rheumatoid arthritis. Although rheum...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198610000-00011
更新日期:1986-10-01 00:00:00
abstract::I reviewed the cases of 50 consecutive patients who had a total of 75 plastic surgery procedures after weight reduction. The average weight loss was 126 lb. There were 28 women and 22 men. The 75 operations were abdominoplasty (24), face-lift (18), reduction mammaplasty (ten), blepharoplasty (eight), mastopexy (eight)...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198711000-00011
更新日期:1987-11-01 00:00:00
abstract::The incidence of acute rheumatic fever in Mississippi was estimated by reviewing the hospital charts of Mississippi residents with a discharge diagnosis of acute rheumatic fever from 1964 through 1973. The average annual incidence was 1.5 cases/100,000 population for primary attacks and 0.4 cases/100,000 population fo...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198105000-00013
更新日期:1981-05-01 00:00:00
abstract::Pregnancy is an unusual occurrence in women with ESRD. We report a successful pregnancy in a patient with ESRD who was receiving hemodialysis; she gave birth to a healthy female infant at 34 weeks' gestational age. We discuss possible physiologic causes of gonadal dysfunction in patients with ESRD. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199102000-00033
更新日期:1991-02-01 00:00:00
abstract::Abscess of the spleen is uncommon and potentially lethal, but until recently it was rarely diagnosed except by exploratory celiotomy or at autopsy. Now, with the advent of radionuclide scanning, ultrasonography, and selective angiography, earlier diagnosis is possible in most cases. We report a case of traumatic absce...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197905000-00019
更新日期:1979-05-01 00:00:00
abstract::A 50-year-old black man was admitted with a diagnosis of a ruptured rotator cuff syndrome two weeks after an injury to the right shoulder and treatment by intra-articular steroid injection. At operation pus and necrotic debris were found in the shoulder joint, but the rotator cuff was anatomically intact. Surgical deb...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198206000-00037
更新日期:1982-06-01 00:00:00
abstract::With the FDA approval of the first cochlear implant device in November 1984, the possibility of the perception of sound became a reality for the profoundly deaf individual. The cochlear implant group of Cincinnati was involved in the coinvestigator study before the approval of the device. This paper presents data from...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198702000-00007
更新日期:1987-02-01 00:00:00
abstract::A 54-year-old woman, perhaps the oldest living American black with homozygous beta thalassemia, has had a relatively benign clinical course since her case was first reported two decades ago. Despite progressive splenomegaly, she has remained active without blood transfusions. This case emphasizes the mildness of homoz...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197609000-00041
更新日期:1976-09-01 00:00:00
abstract::Despite a wealth of publications extolling the virtues of the double contrast barium enema (DCBE), it is clear that change is only gradual and that in many institutions the single contrast, full column barium enema (BE) is still the routine method of colonic investigation. Much of this may be due to a persistent belie...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198201000-00012
更新日期:1982-01-01 00:00:00
abstract:OBJECTIVES:We sought to evaluate whether there is a sex difference in the analgesic response to mu versus kappa opioids in the management of acute moderate to severe pain of injury in the emergency department. METHODS:The study was a randomized, double-blind, clinical trial comparing the prototypical mu-receptor agoni...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.smj.0000085743.68121.a9
更新日期:2004-01-01 00:00:00
abstract::The frequent necessity for termination of pregnancy before the spontaneous onset of labor requires that we be able to accurately predict fetal lung maturity. We have used amniotic fluid studies for evaluation of fetal lung maturity and have found that (1) a "fat" cell concentration of 30% or more, or (2) a creatinine ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197505000-00005
更新日期:1975-05-01 00:00:00
abstract::Implantation of automatic internal cardiac defibrillators (AICD) for management of arrhythmias necessitates the induction of ventricular fibrillation (VF) to test the device adequately. The profound hypotension associated with induced arrhythmia and subsequent circulatory arrest may result in cerebral ischemia. To cha...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199305000-00009
更新日期:1993-05-01 00:00:00
abstract::A technic of combined split-thickness and full-thickness skin grafts and local flap closure for extensive deep cicatricial neck contractures is presented. The head and neck are mobilized by excision of limiting tissues. The lateral neck skin is mobilized to be rotated anteriorly as flaps, and a full-thickness skin gra...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197606000-00023
更新日期:1976-06-01 00:00:00
abstract::We have recently developed a Data Bank for Digestive Disorders, with primary data derived from the performance of upper gastrointestinal endoscopy. By using this system to analyze the clinical characteristics of patients with atypical chest pain, we found information from the patient's history (reflux, dysphagia, abdo...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198301000-00007
更新日期:1983-01-01 00:00:00
abstract::Despite the simplicity, effectiveness, and safety of spinal anesthesia, arachnoiditis can occur as a complication. The cause of this is often unknown, especially since disposable spinal kits are now normally used. It is postulated that an untoward reaction to the anesthesia or chemical contamination was the cause of a...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199311000-00026
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:The blood gas analyzer (BGA) has been considered the "gold standard" for pleural fluid pH determination. METHODS:We report the various methods used to measure pleural fluid pH by 277 acute care institutions who responded to a mailed questionnaire. The techniques used included the BGA (32%), dip stick or pH ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199902000-00010
更新日期:1999-02-01 00:00:00
abstract::A 63-year-old male patient with a history of bipolar I disorder presented to the emergency department in an acutely psychotic state. The patient had just returned from vacation in a malarial high-risk area and, as a result, had taken five weekly doses of mefloquine for prophylaxis. The patient's bipolar disorder was b...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e318167a9e2
更新日期:2008-05-01 00:00:00
abstract::A case of multifocal systemic sporotrichosis presenting with lobar pneumonia caused by Sporothrix schenkii is described. While five cases of pulmonary involvement in multifocal sporotrichosis have been previously reported, all had nodular or cavitary apical lesions. Similarly, unifocal pulmonary sporotrichosis usually...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198106000-00030
更新日期:1981-06-01 00:00:00
abstract::Six patients with classical transient ischemic attacks that were not directly related to extracranial carotid disease are presented. These cases were selected to include a variety of pathologic conditions: one case each of brain tumor, arteriovenous malformation, chronic subdural hematoma, cervical spondylosis, and tw...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197606000-00015
更新日期:1976-06-01 00:00:00
abstract::A case is reported of megaloblastic anemia resulting from folate deficiency in a vegetarian who had been taking oral contraceptives for eight years. A brief report of the pertinent literature is included, ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197502000-00029
更新日期:1975-02-01 00:00:00
abstract::Aminoglycosides have been reported to cause tetany by inducing renal wasting of magnesium and secondary hypocalcemia. A 9-year-old girl with AIDS was brought to the emergency department because of tetany. She had just finished a 3-week course of intravenous tobramycin for bronchiectasis and had an elevated serum tobra...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199611000-00019
更新日期:1996-11-01 00:00:00
abstract::A patient presented with scrotal cellulitis as a complication of infusing 900 ml saline into his scrotum. He had obtained a kit along with explicit instructions for performing the infusion through the Internet. This practice may be more widespread than expected. An Internet search revealed many references to this proc...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000078368.00806.A7
更新日期:2003-07-01 00:00:00