Heterozygous alpha 1-antitrypsin deficiency (PiSZ) in an adolescent with asthma.

Abstract:

:Although alpha 1-antitrypsin deficiency has been associated with obstructive lung disease in individuals possessing a homozygous phenotype (PiZZ), this association has not been as clearly documented in heterozygous individuals (PiMZ, PiMS, and PiSZ phenotypes). Information regarding the heterozygous adolescent population is particularly lacking, making the evaluation and treatment of such patients difficult. We present the case of an adolescent with a history of asthma and heterozygous (PiSZ) alpha 1-antitrypsin deficiency and outline our management with reference to appropriate literature.

journal_name

South Med J

journal_title

Southern medical journal

authors

Nuckton TJ,Beckerman RC

doi

10.1097/00007611-199610000-00018

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

1011-3

issue

10

eissn

0038-4348

issn

1541-8243

journal_volume

89

pub_type

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