Abstract:
:The vast majority of acute iron toxicity cases occur in children less than 5 years of age. Moreover, clinical hepatic injury is uncommon with most symptoms stemming from the intestinal tract (eg, nausea, vomiting, diarrhea). Therefore, physicians, particularly those who do not routinely treat pediatric patients, are often unfamiliar with hepatotoxicity related to iron overdose. Nevertheless, hepatotoxicity caused by acute iron poisoning is associated with a high mortality rate. We report a case of severe hepatic injury in an adult who overdosed on iron tablets with suicidal intent. Tests for other hepatotoxins (eg, acetaminophen), hepatatrophic viruses, and other causes of acute liver injury were negative. Although peak serum iron level (340 microg/dL) was significantly lower than that reported to cause hepatotoxicity (>1,700 microg/dL), rapid and significant elevations in aminotransferases (>4,000 U/L), total bilirubin (5 mg/dL), and prothrombin time (50 seconds) occurred within 48 hours. Treatment with deferoxamine was prompt and followed by empiric N-acetylcysteine once liver injury was apparent. The patient was minimally symptomatic and she eventually had a full recovery.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Daram SR,Hayashi PHdoi
10.1097/01.SMJ.0000152546.05519.FEsubject
Has Abstractpub_date
2005-02-01 00:00:00pages
241-4issue
2eissn
0038-4348issn
1541-8243journal_volume
98pub_type
杂志文章abstract::We have described a case of chronic pancreatitis due to stenosing papillitis relieved by sphincteroplasty and removal of pancreatic duct stones, as opposed to a major pancreatic resection. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198310000-00033
更新日期:1983-10-01 00:00:00
abstract::We describe the case of a patient with acquired immunodeficiency syndrome (AIDS) who had a CD4 cell count of 60/microL, bilateral hilar adenopathy, and hypercalcemia. Transbronchial biopsy showed T-cell anaplastic large cell lymphoma. Serology was negative for human T-cell leukemia virus-I (HTLV-I). This appears to be...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract::Payment systems in the US healthcare system have rewarded physicians for services and attempted to control healthcare spending, with rewards and penalties based upon projected goals for future spending. The incorporation of quality goals and alternatives to fee-for-service was introduced to replace the previous system...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000626
更新日期:2017-04-01 00:00:00
abstract::We performed a retrospective study to determine the sensitivity of mammography in detecting breast cancer arising in women with augmented breasts. Of eight women with breast implants in whom breast cancer developed, six had mammograms before biopsy. Only two of the six cancers were identified mammographically (sensiti...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199101000-00013
更新日期:1991-01-01 00:00:00
abstract::Patients with non-insulin-dependent diabetes mellitus (NIDDM) failing to respond to therapy with a maximum dose of glyburide (GB) or glipizide (GZ) are often given a trial of the alternate second-generation sulfonylurea (SGS) before insulin therapy is considered. The efficacy of this therapeutic maneuver has not been ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199106000-00017
更新日期:1991-06-01 00:00:00
abstract::Gabapentin, an antiepileptic agent, is a safe and versatile medication also used in the adjunctive treatment of painful disorders. These include neuropathic pain, such as postherpetic neuralgia, diabetic neuropathy, and the pain of reflex sympathetic dystrophy. Interstitial cystitis, a painful disease entity, shares m...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:
更新日期:2000-02-01 00:00:00
abstract:OBJECTIVE:Satiety is the perception of satisfied fullness and represents a summation of neural and hormonal influences. Satiety can be assessed by drink tests, including water load. The objective of our study was to confirm the difference in water load volume between nonobese control children and children with function...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000612
更新日期:2017-03-01 00:00:00
abstract::I have described two patients who had recurrent spontaneous myoclonic jerking in the alcohol withdrawal state. These movements were distinguishable clinically and electroencephalographically from partial seizures and epilepsia partialis continua. The jerking did not respond to anticonvulsants but resolved as the withd...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198308000-00028
更新日期:1983-08-01 00:00:00
abstract::Of 24 elderly patients with Streptococcus pneumoniae pneumonia confirmed by transtracheal aspiration, six had concomitant infection with gram-negative aerobic bacilli. All six patients were elderly men with underlying cardiopulmonary disease. Three had had recent prior episodes of gram-negative pneumonia and four had ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198102000-00004
更新日期:1981-02-01 00:00:00
abstract::We reviewed the records of 100 consecutive patients who had gastroscopy. All endoscopic work was done by our four-man surgical group. Roentgenographic and endoscopic diagnoses are compared with reference to degree of accuracy. The expanded uses of gastroscopy in surgical practice are illustrated and a plea is made for...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197802000-00012
更新日期:1978-02-01 00:00:00
abstract::The risks of morbidity and mortality associated with transfusion are so great that no transfusion should be given until it is decided that it is absolutely necessary and then only with the utmost care. The unfavorable effects of transfusion reviewed are: hemolytic reaction; bacterial contamination; febrile reaction du...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1976-04-01 00:00:00
abstract::Lactulose is a poorly absorbed synthetic disaccharide frequently used in the treatment of portasystemic encephalopathy. Because lactulose syrup contains small amounts of absorbable sugars, it may cause hyperglycemia in diabetic individuals, but is usually well tolerated. We report the case of a patient with diet-contr...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199504000-00025
更新日期:1995-04-01 00:00:00
abstract::To study the role of formula as a cause of rickets, we randomly assigned 46 very-low-birth-weight (VLBW) infants (less than or equal to 1,500 gm) to one of three groups receiving either Isomil, a soy isolate formula, Similac with Iron, a common milk-based formula, or Similac 24 LBW, a hypercaloric milk-based formula d...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章
doi:10.1097/00007611-198401000-00005
更新日期:1984-01-01 00:00:00
abstract::A patient presented with scrotal cellulitis as a complication of infusing 900 ml saline into his scrotum. He had obtained a kit along with explicit instructions for performing the infusion through the Internet. This practice may be more widespread than expected. An Internet search revealed many references to this proc...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000078368.00806.A7
更新日期:2003-07-01 00:00:00
abstract::In the ten-year period from 1978 through 1987, 261 patients with intussusception were admitted to Chang Gung Memorial Hospital. The diagnosis was established by barium enema or at laparotomy. The patients were divided into two groups; there were 228 children ranging in age from 1 month to 14 years, and 33 adults. Amon...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1989-02-01 00:00:00
abstract::Interruption of the inferior vena cava by the transvenous placement of a filter or umbrella effectively prevents pulmonary embolism by acting primarily as a physical barrier to emboli. Such a device will be effective only if the site of thrombosis is distal to the planned placement site. We have presented two cases in...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198906000-00025
更新日期:1989-06-01 00:00:00
abstract::We have described a class 4 choledochal cyst in a 24-year-old black woman treated with choledochocystoduodenostomy. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198605000-00034
更新日期:1986-05-01 00:00:00
abstract::We have described a case of thrombocytopenic purpura caused by methyldopa. A methyldopa-dependent antiplatelet antibody as the mechanism of the patient's thrombopenia was suggested by a positive clot retraction inhibition test. This simple in vitro test should be done more often in suspected cases of drug-induced thro...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198203000-00036
更新日期:1982-03-01 00:00:00
abstract:BACKGROUND:Physicians often treat patients with physical illnesses that have a functional component. Investigators have discovered that many of these patients have unresolved emotional problems associated with histories of trauma and abuse. METHODS:Abused and traumatized patients with medical complaints often seek med...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:
更新日期:1998-04-01 00:00:00
abstract::Food safety is an increasing concern to Americans. Recent recalls of peanuts and pistachios, and Food and Drug Administration (FDA) warnings to pregnant women to avoid eating fish have increased government oversight of food processing and handling. Consumers can play an important role in alerting their healthcare prov...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181be29af
更新日期:2010-04-01 00:00:00
abstract::A case of carcinoma of the ampulla of Vater was diagnosed preoperatively by percutaneous transhepatic cholangiography using the Chiba needle. A dilated pancreatic duct is a radiologic sign diagnostic of early ampullary carcinoma. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197912000-00051
更新日期:1979-12-01 00:00:00
abstract::Keloid management remains controversial, and recurrence and untoward side effects limit the use of many techniques. During a seven-year period, I surgically treated 19 children, aged 3 to 17 (mean 10.5 years), with a total of 28 keloids. After aseptic skin preparation, the interface between the keloid and normal skin ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198806000-00013
更新日期:1988-06-01 00:00:00
abstract::A 64-year-old woman had the syndrome of inappropriate ADH secretion (SIADH) after surgical repair of a ruptured aneurysm of the anterior communicating artery. SIADH began while the intracranial pressure was elevated, and resolved when the pressure returned to normal. Whether this syndrome was caused by direct hypothal...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198007000-00030
更新日期:1980-07-01 00:00:00
abstract::The aim of this project was to review the course of infants referred for consideration of extracorporeal membrane oxygenation (ECMO) to identify maximal ventilator settings that, when exceeded, did not provide clinical benefit to the patient. These settings might then be used in defining failure of conventional mechan...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199706000-00009
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVES:Immunochromatographic urine pneumococcal antigen testing (ICT) has become a common diagnostic tool for those presenting with possible invasive pneumococcal disease. The incidence and clinical impact of ICT false-positivity on hospitalized patients has not been assessed outside of specific patient subpopulati...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3182273b82
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVES:In 2014, 726 bicyclists were killed and an additional 50,000 were injured in crashes with motor vehicles. The number of cyclists in the United States is increasing, and as a result there has been a call for more bike lanes. We examined the difference in the severity of injury of bicyclists involved in motor ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000665
更新日期:2017-07-01 00:00:00
abstract::Swing beds contribute significantly to inpatient rehabilitation and skilled nursing care of the rural elderly, but little information is available in the general clinical literature regarding the types and outcomes of patients admitted to these programs. All swing bed admissions to a small rural hospital for the 1989 ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199212000-00008
更新日期:1992-12-01 00:00:00
abstract::Gastrointestinal side effects from nonsteroidal anti-inflammatory drugs (NSAIDs) result mainly from inhibition of the enzyme cyclooxygenase (COX)-1; it is responsible for the synthesis of prostaglandin E2, which leads to increased mucosal blood flow, increased bicarbonate secretion, and mucus production, thus protecti...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND:Smokeless tobacco (ST) use is associated with significant health risks and is increasing in prevalence in the United States. This study examined the prevalence of ST use among patients seen in two family practice centers and the documentation of that ST use in the medical record. METHODS:A survey of 209 pat...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199712000-00012
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:Insulin resistance is characterized by impaired responsiveness to endogenous or exogenous insulin. Loss of responsiveness is associated with a "clustering" of cardiovascular risk factors that includes abdominal obesity, hypertension, dyslipidemia, glucose intolerance, and hyperinsulinemia; this association i...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199901000-00002
更新日期:1999-01-01 00:00:00