Crossover comparison of maximum dose glyburide and glipizide.

Abstract:

:Patients with non-insulin-dependent diabetes mellitus (NIDDM) failing to respond to therapy with a maximum dose of glyburide (GB) or glipizide (GZ) are often given a trial of the alternate second-generation sulfonylurea (SGS) before insulin therapy is considered. The efficacy of this therapeutic maneuver has not been thoroughly tested. We studied 26 subjects with fasting serum glucose (FSG) levels greater than 8.3 mmol/L (150 mg/dL) despite maximum doses of either GB (20 mg/day) or GZ (40 mg/day). Group 1 consisted of 16 subjects taking GB (mean FSG = 12.7 mmol/L [228 mg/dL]) and group 2 included 10 subjects taking GZ (mean FSG = 13.0 mmol/L [234 mg/dL]). Subjects continued taking their original SGS for 8 weeks then switched to a maximum dose of the alternate agent for an additional 8 weeks. Values for FSG, hemoglobin A1c, and lipids were recorded before the study and after 8 weeks on each SGS trial. No significant changes were noted for any variable in either group. When maximum dose GB therapy was compared to maximum dose GZ therapy in the combined study group (n = 26), no advantage was noted for either agent. We conclude that metabolic control in NIDDM patients failing to respond to therapy with maximum dose GB or GZ is not improved by switching to the alternate SGS.

journal_name

South Med J

journal_title

Southern medical journal

authors

Simcic KJ,McDermott MT,White JC,Kidd GS

doi

10.1097/00007611-199106000-00017

subject

Has Abstract

pub_date

1991-06-01 00:00:00

pages

743-6

issue

6

eissn

0038-4348

issn

1541-8243

journal_volume

84

pub_type

杂志文章
  • Transient synovitis of the hip in an adult.

    abstract::Transient synovitis of the hip is an acute and self-limited disease commonly seen in children. It is the most common cause of acute hip pain in children ages 3 to 10. It is not considered a disease of adults. It usually only affects one hip. The child may complain of pain that is much worse with walking and may actual...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/01.smj.0000199746.29009.4c

    authors: Quintos-Macasa AM,Serebro L,Menon Y

    更新日期:2006-02-01 00:00:00

  • Predictive factors for septic shock in patients with ventilator-associated pneumonia.

    abstract:BACKGROUND:Ventilator-associated pneumonia (VAP) is one of the most frequent infections in intensive care units (ICUs), and nearly 50% of patients with VAP develop septic shock. Septic shock is an independent predictor for mortality in these patients. OBJECTIVE:To investigate the predictors for septic shock in VAP pat...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/SMJ.0b013e3181827891

    authors: Aydogdu M,Gursel G

    更新日期:2008-12-01 00:00:00

  • Primary mucus-secreting adenocarcinoma of the renal pelvis.

    abstract::Mucus-secreting adenocarcinoma of the renal pelvis is an extremely rare tumor. It arises from multipotential transitional epithelium which is capable of undergoing metaplastic transformation when subjected to chronic irritation from calculi, hydronephrosis, or pyelonephritis. Women are affected slightly more often tha...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-197910000-00038

    authors: Wild RM,Ladaga LE,Copeland JS,Schellhammer PF

    更新日期:1979-10-01 00:00:00

  • Acute progressive bilateral carpal tunnel syndrome after upper respiratory tract infection.

    abstract::This report describes the case of a 32-year-old male presenting with acute progressive bilateral carpal tunnel syndrome after a benign upper respiratory tract infection. Serial nerve conduction studies confirmed progressive entrapment of the median nerves in the carpal tunnel to the point of axonal damage. Surgical de...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/01.smj.0000182502.23548.41

    authors: El Hajj II,Harb MI,Sawaya RA

    更新日期:2005-11-01 00:00:00

  • Chinese red rice-induced myopathy.

    abstract::A middle-aged man presented with joint pain and muscle weakness that had begun 2 months before presentation. Three months before presentation, he had begun to take the herbal preparation Chinese red rice. Laboratory testing revealed a moderately elevated creatine phosphokinase level. Symptoms and laboratory abnormalit...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/01.SMJ.0000100117.79718.DC

    authors: Smith DJ,Olive KE

    更新日期:2003-12-01 00:00:00

  • Risk Factors for 30-Day Readmissions of Individuals with Decompensated Cirrhosis.

    abstract:OBJECTIVES:Patients with cirrhosis have a high rate of 30-day hospital readmission that affects their quality of life and contributes to increased healthcare-related costs. The aim of our study was to identify frequency, predictors, and preventable causes of hospital readmissions among patients with decompensated cirrh...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.14423/SMJ.0000000000000371

    authors: Agrawal K,Kumar P,Markert R,Agrawal S

    更新日期:2015-11-01 00:00:00

  • Addisonian crisis precipitated by thyroxine therapy: a complication of type 2 autoimmune polyglandular syndrome.

    abstract::Hypothyroidism is a common condition. Rarely, it may occur in combination with autoimmune failure of other endocrine glands (autoimmune polyendocrinopathy syndrome type 2, previously known as Schmidt's syndrome). In such cases, restoring normal thyroid function may precipitate adrenal failure. Clinicians should have a...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/01.SMJ.0000056647.58668.CD

    authors: Graves L 3rd,Klein RM,Walling AD

    更新日期:2003-08-01 00:00:00

  • Enchondromatosis with hemangiomas (Maffucci's syndrome).

    abstract::Maffucci's syndrome in a 17-year-old girl is reported. Since the entity was first described in 1881 by Maffucci, 105 additional cases have been recorded. Several series have reported a small but significant percentage of cases (up to 18%) with malignant change. Our case, although not particularly unique in comparison ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-197804000-00033

    authors: Gutman E,McCutcheon S,Garber P

    更新日期:1978-04-01 00:00:00

  • Swing bed program in a small rural hospital: discharge outcome.

    abstract::Swing beds contribute significantly to inpatient rehabilitation and skilled nursing care of the rural elderly, but little information is available in the general clinical literature regarding the types and outcomes of patients admitted to these programs. All swing bed admissions to a small rural hospital for the 1989 ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-199212000-00008

    authors: Lammers JE

    更新日期:1992-12-01 00:00:00

  • Tuberculous peritonitis: fatality associated with delayed diagnosis.

    abstract::We describe a fatal case of tuberculous peritonitis and review the literature on the diagnostic modalities available to diagnose this entity. We suspect a delayed diagnosis resulted in the death of our patient. Today, the prompt diagnosis of an unknown ascitic process involves laparoscopy. A patient with unknown large...

    journal_title:Southern medical journal

    pub_type: 杂志文章,评审

    doi:10.1097/00007611-199904000-00010

    authors: Ahmad M,Ahmed A

    更新日期:1999-04-01 00:00:00

  • Use of a national data base to assess perioperative risk, morbidity, mortality, and cost savings in coronary artery bypass grafting.

    abstract::To show the usefulness of the Society of Thoracic Surgeons (STS) National Database in providing clinical and cost-related outcome data, we studied 297 consecutive patients who had isolated coronary artery bypass grafting (CABG) and who were assigned to either a "fast track" or traditional track. The observed overall m...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-199611000-00009

    authors: Nikas DJ,Freeman JE,Luterman AR,Warnken LC,Nenstiel RD,Farrell M,Alpert MA

    更新日期:1996-11-01 00:00:00

  • Trimethoprim-sulfamethoxazole in the treatment of gonorrhea: comparison with standard treatment schedules.

    abstract::Several treatment regimens of trimethoprim-sulfamethoxazole (TMP-SMZ) were compared to the USPHS-recommended schedules for treatment of uncomplicated gonorrhea with ampicillin plus probenecid, tetracycline, or aqueous procaine penicillin G in both men and women. TMP-SMZ, six tablets as a single oral dose daily for 3 d...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-197509000-00020

    authors: Duncan WC,Knox JM,Jackson TH

    更新日期:1975-09-01 00:00:00

  • Sex differences in analgesia: a randomized trial of mu versus kappa opioid agonists.

    abstract:OBJECTIVES:We sought to evaluate whether there is a sex difference in the analgesic response to mu versus kappa opioids in the management of acute moderate to severe pain of injury in the emergency department. METHODS:The study was a randomized, double-blind, clinical trial comparing the prototypical mu-receptor agoni...

    journal_title:Southern medical journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/01.smj.0000085743.68121.a9

    authors: Miller PL,Ernst AA

    更新日期:2004-01-01 00:00:00

  • Hypogammaglobulinemia in infants infected with human immunodeficiency virus.

    abstract::Two premature infants were infected with HIV via blood transfusions during the neonatal period. Although neither patient had serum antibody to HIV owing to severe hypogammaglobulinemia, HIV infection was confirmed by finding HIV antigen in the sera of both patients. These cases show that HIV infection can produce seve...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198904000-00005

    authors: Saulsbury FT

    更新日期:1989-04-01 00:00:00

  • Cardiac tamponade: an unusual complication of simultaneous treatment of tuberculosis and HIV.

    abstract::Human immunodeficiency virus (HIV) has caused resurgence in tuberculosis (TB) worldwide. HIV-TB coinfected individuals are at increased risk for complications of TB and HIV treatment, such as adverse drug reactions and immune reconstitution syndrome. A 17-year-old male with HIV-TB coinfection, who developed cardiac ta...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/SMJ.0b013e3181684b92

    authors: Wang SH,Menon A,Hyslop NE

    更新日期:2008-05-01 00:00:00

  • Painful edema of the arm after insertion of single-needle subclavian vein dialysis catheters: pathogenesis and treatment.

    abstract::The percutaneous subclavian vein hemodialysis catheter, which is widely used for vascular access in patients with renal failure, can give rise to several complications. Asymptomatic stenosis or occlusion of the subclavian vein due to these catheters can lead to painful arm edema if further dialysis accesses are constr...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198803000-00004

    authors: Coates GR,Clements JB,Yium J,Watlington J

    更新日期:1988-03-01 00:00:00

  • Haff disease after eating salmon.

    abstract::While fish consumption is considered a component of a heart-healthy diet, many illnesses have been associated with eating contaminated fish. The authors describe two cases of muscle weakness and rhabdomyolysis that occurred after eating salmon. Cases of rhabdomyolysis and muscle weakness after consumption of fresh wat...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/SMJ.0b013e3181583673

    authors: Langley RL,Bobbitt WH 3rd

    更新日期:2007-11-01 00:00:00

  • Hypothyroidism with coexistent asthma: problems in management.

    abstract::This case study illustrates the relationship between hypothyroidism and bronchial asthma. As seen here, even slow and cautious restoration of the euthyroid state may lead to problems in the management of asthma. Thus routine or aggressive replacement therapy for thyroid hypofunction in the asthmatic population is not ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198403000-00037

    authors: Rowe MS,MacKechnie HL

    更新日期:1984-03-01 00:00:00

  • Pigmented villonodular synovitis of the knee in a 9-year-old child.

    abstract::This report describes a 9-year-old girl with pigmented villonodular synovitis of the right knee. She presented with a chronic bloody effusion of the knee. The diagnosis of pigmented villonodular synovitis was suggested by the findings on magnetic resonance imaging and confirmed at the time of arthroscopic synovectomy....

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/01.SMJ.0000104842.97001.88

    authors: Saulsbury FT

    更新日期:2004-01-01 00:00:00

  • Primary carcinoma of the trachea: report of two cases.

    abstract::Primary carcinoma of the trachea is not common. Of 23 cases diagnosed as "carcinoma of the trachea" at our institution since 1949, 21 actually represented secondary involvement from carcinoma of the larynx, lung, or esophagus. The two cases of primary carcinoma of the trachea are presented. Discussed are the relation ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-197704000-00020

    authors: Goldstein J

    更新日期:1977-04-01 00:00:00

  • Intramural duodenal hematoma in children: reappraisal of current management.

    abstract::In children, intramural duodenal hematomas resulting from blunt abdominal trauma are generally managed nonoperatively with nasogastric suction and parenteral nutrition. Experience with three cases in which this form of treatment failed caused us to reappraise its benefits and results. Consequently, we now recommend su...

    journal_title:Southern medical journal

    pub_type: 杂志文章,评审

    doi:10.1097/00007611-198808000-00011

    authors: Thoms CA,Ricketts RR

    更新日期:1988-08-01 00:00:00

  • Frequency of β-Blocker Use Following Exacerbations of COPD in Patients with Compelling Indication for Use.

    abstract:OBJECTIVE:To assess the current use of β-blockers in patients with compelling indications for use, following the acute exacerbation of chronic obstructive pulmonary disease (COPD). METHODS:We performed a multicenter retrospective observational study using data from all of the patients admitted to five institutions for...

    journal_title:Southern medical journal

    pub_type: 杂志文章,多中心研究

    doi:10.14423/SMJ.0000000000001038

    authors: Pinner N,Oliver W,Veasey T,Starr J,Eudaley S,Hutchison A,Wargo K

    更新日期:2019-11-01 00:00:00

  • Postoperative analgesia after major shoulder surgery with interscalene brachial plexus blockade: etidocaine versus bupivacaine.

    abstract::Postoperative pain is commonly treated with significant doses of narcotics, occasionally resulting in side effects including nausea, pruritus, and respiratory depression. One potential advantage of regional anesthesia is profound postoperative analgesia that reduces exposure to potent narcotics. To evaluate the effica...

    journal_title:Southern medical journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00007611-199404000-00016

    authors: Dorman BH,Conroy JM,Duc TA Jr,Haynes GR,Friedman RJ

    更新日期:1994-04-01 00:00:00

  • Long-term survival after autologous bone marrow transplantation for metastatic breast carcinoma.

    abstract::A phase II study of doxorubicin (Adriamycin)-based induction chemotherapy followed by cyclophosphamide/BCNU (CyBCNU) intensification and autologous bone marrow transplantation (ABMT) was conducted in 20 consecutive women with hormone-resistant metastatic breast cancer referred to our center. Of these 20 women, aged 24...

    journal_title:Southern medical journal

    pub_type: 临床试验,杂志文章

    doi:10.1097/00007611-199503000-00015

    authors: Saez RA,Slease RB,Selby GB,Strnad C,Epstein RB,Confer DL

    更新日期:1995-03-01 00:00:00

  • Thrombocytopenia and cancer: use of the Kim-Ray Greenfield filter to prevent thromboembolism.

    abstract::The association of hypercoagulation and cancer, a well established pattern of disease, often leads to pulmonary emboli in an already compromised patient. Anticoagulation therapy in these patients is occasionally complicated by several factors including thrombocytopenia, which may result in a life-threatening situation...

    journal_title:Southern medical journal

    pub_type: 临床试验,杂志文章

    doi:

    authors: Whitney BA,Kerstein MD

    更新日期:1987-10-01 00:00:00

  • Hand infections in the elderly.

    abstract::Diagnosis and management of hand infections in the elderly can be challenging. The general principles of rest, elevation, compresses, and drainage when appropriate apply. Antibiotics are important to therapy. Review of data from elderly patients and comparison with a younger population having identical infections show...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198502000-00009

    authors: Stromberg BV

    更新日期:1985-02-01 00:00:00

  • Penetrating neck injuries.

    abstract::Penetrating neck trauma may be managed operatively or nonoperatively, depending on precise anatomic location. Conservative management of zone II injuries is currently an issue under debate. We present a brief case report followed by a description of the current strategies for operative exploration and diagnostic maneu...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:

    authors: Siegrist B,Steeb G

    更新日期:2000-06-01 00:00:00

  • Surgical treatment of mitral valve disease: pathologic findings and atrial dysrhythmia.

    abstract::One hundred fifty patients underwent surgery for mitral valve disease between January 1974 and May 1981. There were 98 female and 52 male patients with a mean age of 57 years (+/- 18.6). One hundred forty-six patients were in New York Heart Association functional class III or IV. Pathologic diagnoses included 67% rheu...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/00007611-198306000-00005

    authors: Vijayanagar R,Bognolo D,Eckstein P,Jeffery D,Toole J,Natarajan P,Willard E

    更新日期:1983-06-01 00:00:00

  • Guillain-Barré syndrome as a paraneoplastic manifestation of small-cell carcinoma of lung.

    abstract::Guillain-Barré syndrome (GBS) encompasses the variants of acute immune-mediated polyneuropathies usually preceded by an infection. A few case reports have associated GBS to neoplastic diseases. It remains unclear whether these are merely coincidental or represent paraneoplastic phenomena. The clinical features of GBS ...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/smj.0b013e3181bfd2c0

    authors: Naveed S,Okoli K,Hollingsworth J,Kasmani R

    更新日期:2010-02-01 00:00:00

  • Efficacy and safety of sodium phosphate for colon cleansing in type 2 diabetes mellitus.

    abstract:OBJECTIVES:The need for colonoscopy is common among diabetic patients. However, there are no standards per se for bowel preparation in patients with type 2 diabetes. In this study, we evaluated the efficacy, safety, and tolerability of sodium phosphate (NaP), and the quality of bowel cleansing in relation to glycemic c...

    journal_title:Southern medical journal

    pub_type: 杂志文章

    doi:10.1097/SMJ.0b013e3181f20b13

    authors: Ozturk NA,Gokturk HS,Demir M,Unler GK,Gur G,Yilmaz U

    更新日期:2010-11-01 00:00:00