Abstract:
:Patients with non-insulin-dependent diabetes mellitus (NIDDM) failing to respond to therapy with a maximum dose of glyburide (GB) or glipizide (GZ) are often given a trial of the alternate second-generation sulfonylurea (SGS) before insulin therapy is considered. The efficacy of this therapeutic maneuver has not been thoroughly tested. We studied 26 subjects with fasting serum glucose (FSG) levels greater than 8.3 mmol/L (150 mg/dL) despite maximum doses of either GB (20 mg/day) or GZ (40 mg/day). Group 1 consisted of 16 subjects taking GB (mean FSG = 12.7 mmol/L [228 mg/dL]) and group 2 included 10 subjects taking GZ (mean FSG = 13.0 mmol/L [234 mg/dL]). Subjects continued taking their original SGS for 8 weeks then switched to a maximum dose of the alternate agent for an additional 8 weeks. Values for FSG, hemoglobin A1c, and lipids were recorded before the study and after 8 weeks on each SGS trial. No significant changes were noted for any variable in either group. When maximum dose GB therapy was compared to maximum dose GZ therapy in the combined study group (n = 26), no advantage was noted for either agent. We conclude that metabolic control in NIDDM patients failing to respond to therapy with maximum dose GB or GZ is not improved by switching to the alternate SGS.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Simcic KJ,McDermott MT,White JC,Kidd GSdoi
10.1097/00007611-199106000-00017subject
Has Abstractpub_date
1991-06-01 00:00:00pages
743-6issue
6eissn
0038-4348issn
1541-8243journal_volume
84pub_type
杂志文章abstract::Transient synovitis of the hip is an acute and self-limited disease commonly seen in children. It is the most common cause of acute hip pain in children ages 3 to 10. It is not considered a disease of adults. It usually only affects one hip. The child may complain of pain that is much worse with walking and may actual...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.smj.0000199746.29009.4c
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:Ventilator-associated pneumonia (VAP) is one of the most frequent infections in intensive care units (ICUs), and nearly 50% of patients with VAP develop septic shock. Septic shock is an independent predictor for mortality in these patients. OBJECTIVE:To investigate the predictors for septic shock in VAP pat...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181827891
更新日期:2008-12-01 00:00:00
abstract::Mucus-secreting adenocarcinoma of the renal pelvis is an extremely rare tumor. It arises from multipotential transitional epithelium which is capable of undergoing metaplastic transformation when subjected to chronic irritation from calculi, hydronephrosis, or pyelonephritis. Women are affected slightly more often tha...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197910000-00038
更新日期:1979-10-01 00:00:00
abstract::This report describes the case of a 32-year-old male presenting with acute progressive bilateral carpal tunnel syndrome after a benign upper respiratory tract infection. Serial nerve conduction studies confirmed progressive entrapment of the median nerves in the carpal tunnel to the point of axonal damage. Surgical de...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.smj.0000182502.23548.41
更新日期:2005-11-01 00:00:00
abstract::A middle-aged man presented with joint pain and muscle weakness that had begun 2 months before presentation. Three months before presentation, he had begun to take the herbal preparation Chinese red rice. Laboratory testing revealed a moderately elevated creatine phosphokinase level. Symptoms and laboratory abnormalit...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000100117.79718.DC
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVES:Patients with cirrhosis have a high rate of 30-day hospital readmission that affects their quality of life and contributes to increased healthcare-related costs. The aim of our study was to identify frequency, predictors, and preventable causes of hospital readmissions among patients with decompensated cirrh...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000371
更新日期:2015-11-01 00:00:00
abstract::Hypothyroidism is a common condition. Rarely, it may occur in combination with autoimmune failure of other endocrine glands (autoimmune polyendocrinopathy syndrome type 2, previously known as Schmidt's syndrome). In such cases, restoring normal thyroid function may precipitate adrenal failure. Clinicians should have a...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000056647.58668.CD
更新日期:2003-08-01 00:00:00
abstract::Maffucci's syndrome in a 17-year-old girl is reported. Since the entity was first described in 1881 by Maffucci, 105 additional cases have been recorded. Several series have reported a small but significant percentage of cases (up to 18%) with malignant change. Our case, although not particularly unique in comparison ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197804000-00033
更新日期:1978-04-01 00:00:00
abstract::Swing beds contribute significantly to inpatient rehabilitation and skilled nursing care of the rural elderly, but little information is available in the general clinical literature regarding the types and outcomes of patients admitted to these programs. All swing bed admissions to a small rural hospital for the 1989 ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199212000-00008
更新日期:1992-12-01 00:00:00
abstract::We describe a fatal case of tuberculous peritonitis and review the literature on the diagnostic modalities available to diagnose this entity. We suspect a delayed diagnosis resulted in the death of our patient. Today, the prompt diagnosis of an unknown ascitic process involves laparoscopy. A patient with unknown large...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199904000-00010
更新日期:1999-04-01 00:00:00
abstract::To show the usefulness of the Society of Thoracic Surgeons (STS) National Database in providing clinical and cost-related outcome data, we studied 297 consecutive patients who had isolated coronary artery bypass grafting (CABG) and who were assigned to either a "fast track" or traditional track. The observed overall m...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199611000-00009
更新日期:1996-11-01 00:00:00
abstract::Several treatment regimens of trimethoprim-sulfamethoxazole (TMP-SMZ) were compared to the USPHS-recommended schedules for treatment of uncomplicated gonorrhea with ampicillin plus probenecid, tetracycline, or aqueous procaine penicillin G in both men and women. TMP-SMZ, six tablets as a single oral dose daily for 3 d...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197509000-00020
更新日期:1975-09-01 00:00:00
abstract:OBJECTIVES:We sought to evaluate whether there is a sex difference in the analgesic response to mu versus kappa opioids in the management of acute moderate to severe pain of injury in the emergency department. METHODS:The study was a randomized, double-blind, clinical trial comparing the prototypical mu-receptor agoni...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.smj.0000085743.68121.a9
更新日期:2004-01-01 00:00:00
abstract::Two premature infants were infected with HIV via blood transfusions during the neonatal period. Although neither patient had serum antibody to HIV owing to severe hypogammaglobulinemia, HIV infection was confirmed by finding HIV antigen in the sera of both patients. These cases show that HIV infection can produce seve...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198904000-00005
更新日期:1989-04-01 00:00:00
abstract::Human immunodeficiency virus (HIV) has caused resurgence in tuberculosis (TB) worldwide. HIV-TB coinfected individuals are at increased risk for complications of TB and HIV treatment, such as adverse drug reactions and immune reconstitution syndrome. A 17-year-old male with HIV-TB coinfection, who developed cardiac ta...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181684b92
更新日期:2008-05-01 00:00:00
abstract::The percutaneous subclavian vein hemodialysis catheter, which is widely used for vascular access in patients with renal failure, can give rise to several complications. Asymptomatic stenosis or occlusion of the subclavian vein due to these catheters can lead to painful arm edema if further dialysis accesses are constr...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198803000-00004
更新日期:1988-03-01 00:00:00
abstract::While fish consumption is considered a component of a heart-healthy diet, many illnesses have been associated with eating contaminated fish. The authors describe two cases of muscle weakness and rhabdomyolysis that occurred after eating salmon. Cases of rhabdomyolysis and muscle weakness after consumption of fresh wat...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181583673
更新日期:2007-11-01 00:00:00
abstract::This case study illustrates the relationship between hypothyroidism and bronchial asthma. As seen here, even slow and cautious restoration of the euthyroid state may lead to problems in the management of asthma. Thus routine or aggressive replacement therapy for thyroid hypofunction in the asthmatic population is not ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198403000-00037
更新日期:1984-03-01 00:00:00
abstract::This report describes a 9-year-old girl with pigmented villonodular synovitis of the right knee. She presented with a chronic bloody effusion of the knee. The diagnosis of pigmented villonodular synovitis was suggested by the findings on magnetic resonance imaging and confirmed at the time of arthroscopic synovectomy....
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000104842.97001.88
更新日期:2004-01-01 00:00:00
abstract::Primary carcinoma of the trachea is not common. Of 23 cases diagnosed as "carcinoma of the trachea" at our institution since 1949, 21 actually represented secondary involvement from carcinoma of the larynx, lung, or esophagus. The two cases of primary carcinoma of the trachea are presented. Discussed are the relation ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197704000-00020
更新日期:1977-04-01 00:00:00
abstract::In children, intramural duodenal hematomas resulting from blunt abdominal trauma are generally managed nonoperatively with nasogastric suction and parenteral nutrition. Experience with three cases in which this form of treatment failed caused us to reappraise its benefits and results. Consequently, we now recommend su...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-198808000-00011
更新日期:1988-08-01 00:00:00
abstract:OBJECTIVE:To assess the current use of β-blockers in patients with compelling indications for use, following the acute exacerbation of chronic obstructive pulmonary disease (COPD). METHODS:We performed a multicenter retrospective observational study using data from all of the patients admitted to five institutions for...
journal_title:Southern medical journal
pub_type: 杂志文章,多中心研究
doi:10.14423/SMJ.0000000000001038
更新日期:2019-11-01 00:00:00
abstract::Postoperative pain is commonly treated with significant doses of narcotics, occasionally resulting in side effects including nausea, pruritus, and respiratory depression. One potential advantage of regional anesthesia is profound postoperative analgesia that reduces exposure to potent narcotics. To evaluate the effica...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007611-199404000-00016
更新日期:1994-04-01 00:00:00
abstract::A phase II study of doxorubicin (Adriamycin)-based induction chemotherapy followed by cyclophosphamide/BCNU (CyBCNU) intensification and autologous bone marrow transplantation (ABMT) was conducted in 20 consecutive women with hormone-resistant metastatic breast cancer referred to our center. Of these 20 women, aged 24...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章
doi:10.1097/00007611-199503000-00015
更新日期:1995-03-01 00:00:00
abstract::The association of hypercoagulation and cancer, a well established pattern of disease, often leads to pulmonary emboli in an already compromised patient. Anticoagulation therapy in these patients is occasionally complicated by several factors including thrombocytopenia, which may result in a life-threatening situation...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章
doi:
更新日期:1987-10-01 00:00:00
abstract::Diagnosis and management of hand infections in the elderly can be challenging. The general principles of rest, elevation, compresses, and drainage when appropriate apply. Antibiotics are important to therapy. Review of data from elderly patients and comparison with a younger population having identical infections show...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198502000-00009
更新日期:1985-02-01 00:00:00
abstract::Penetrating neck trauma may be managed operatively or nonoperatively, depending on precise anatomic location. Conservative management of zone II injuries is currently an issue under debate. We present a brief case report followed by a description of the current strategies for operative exploration and diagnostic maneu...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
abstract::One hundred fifty patients underwent surgery for mitral valve disease between January 1974 and May 1981. There were 98 female and 52 male patients with a mean age of 57 years (+/- 18.6). One hundred forty-six patients were in New York Heart Association functional class III or IV. Pathologic diagnoses included 67% rheu...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198306000-00005
更新日期:1983-06-01 00:00:00
abstract::Guillain-Barré syndrome (GBS) encompasses the variants of acute immune-mediated polyneuropathies usually preceded by an infection. A few case reports have associated GBS to neoplastic diseases. It remains unclear whether these are merely coincidental or represent paraneoplastic phenomena. The clinical features of GBS ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/smj.0b013e3181bfd2c0
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVES:The need for colonoscopy is common among diabetic patients. However, there are no standards per se for bowel preparation in patients with type 2 diabetes. In this study, we evaluated the efficacy, safety, and tolerability of sodium phosphate (NaP), and the quality of bowel cleansing in relation to glycemic c...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181f20b13
更新日期:2010-11-01 00:00:00