Sucralfate in the relief of gastrointestinal symptoms associated with nonsteroidal anti-inflammatory drugs.

Abstract:

:Sucralfate is an unabsorbed antiulcer drug that binds to gastrointestinal tissue and protects it from acid and pepsin. Twenty-two arthritic patients taking nonsteroidal anti-inflammatory drugs (NSAIDs) were given sucralfate concomitantly for two weeks in an attempt to lessen gastrointestinal side effects. Changes from baseline in abdominal discomfort were assessed after 2, 7, 10 (or 11), and 14 days of treatment. Sucralfate administration was accompanied by the disappearance of heartburn, epigastric pain, epigastric distress, or epigastric burning in 42 of 59 occurrences, and by statistically significant reductions in bloating. There was a trend toward significance in decreased nocturnal abdominal pain and in belching. Overall improvement, assessed at the completion of each patient's treatment, also was statistically significant.

journal_name

South Med J

journal_title

Southern medical journal

authors

Caldwell JR

doi

10.1097/00007611-198508000-00011

subject

Has Abstract

pub_date

1985-08-01 00:00:00

pages

938-40

issue

8

eissn

0038-4348

issn

1541-8243

journal_volume

78

pub_type

杂志文章
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