Abstract:
BACKGROUND:Erythromycin has been associated with prolongation of myocardial repolarization and torsades de pointes (TdP). METHODS:To determine the frequency, dose-response, and risk factors for erythromycin-associated prolongation of myocardial repolarization, we observed data of patients admitted to our hospital with pneumonia who were treated with erythromycin. RESULTS:In 35 women and 28 men enrolled in this study, the QTc increased from 434 +/- 4 milliseconds at baseline to 464 +/- 5 milliseconds after receiving a cumulative dose of 3.2 +/- 0.2 g of erythromycin. Neither age, sex, presence of preexistent congestive heart failure/coronary artery disease, electrolyte values, nor cumulative dose of erythromycin was associated with QTc prolongation. In 27 patients who received intravenous erythromycin for 3 days, the QTc increased from 427 +/- 5 milliseconds before to 461 +/- 8 milliseconds at 24 hours but did not increase further by day 3 (457 +/- 10 milliseconds). No patient in this cohort had TdP. CONCLUSIONS:Erythromycin therapy is associated with prolongation of myocardial repolarization that manifests after the first few doses in a majority of patients.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Kdesh A,McPherson CA,Yaylali Y,Yasick D,Bradley K,Manthous CAdoi
10.1097/00007611-199912000-00009subject
Has Abstractpub_date
1999-12-01 00:00:00pages
1178-82issue
12eissn
0038-4348issn
1541-8243journal_volume
92pub_type
杂志文章abstract::A middle-aged man presented with joint pain and muscle weakness that had begun 2 months before presentation. Three months before presentation, he had begun to take the herbal preparation Chinese red rice. Laboratory testing revealed a moderately elevated creatine phosphokinase level. Symptoms and laboratory abnormalit...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000100117.79718.DC
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVE:Few tests of functional motor behavior are useful for rapidly screening people for lower extremity peripheral neuropathy. The goal of this study was to improve the widely used tandem walking (TW) test. METHODS:We tested "normal" (control) adult and ambulatory patients with peripheral neuropathy (PN) with the...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章
doi:10.1097/SMJ.0000000000000009
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVES:To assess the efficacy of laparoscopic Nissen fundoplication for esophageal reflux in a community hospital. METHODS:One hundred nineteen patients (76%) of 157 patients having laparoscopic fundoplication for symptomatic reflux disease completed a questionnaire. All patients were evaluated with esophagoscopy,...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000146585.51335.76
更新日期:2005-04-01 00:00:00
abstract::In a ten-year period 139 patients with epidermoid carcinoma of the esophagus were treated by palliative feeding procedures, palliative radiation therapy, radiation therapy for cure, or resection. Analysis of the results of these modes of therapy indicates that long-term palliation is best achieved when resection is th...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197606000-00016
更新日期:1976-06-01 00:00:00
abstract::Two patients with polycystic kidney disease and renal failure developed profound hypotension within 30 minutes after starting hemodialysis. After ruling out all recognized causes of hypotension during early dialysis, we found that their vena cavas were obstructed by compression of the vessels against the spinal column...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197911000-00013
更新日期:1979-11-01 00:00:00
abstract::Severe lactic acidosis is often associated with poor prognosis. Recognition and correction of the underlying process is the major step in the treatment of this serious condition. Intravenous administration of sodium bicarbonate has been the mainstay in the treatment of lactic acidosis. Aggressive use of this therapeut...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-198107000-00018
更新日期:1981-07-01 00:00:00
abstract::Squamous cell carcinoma of the cervix is a common malignancy, but like other genital malignancies, it rarely metastasizes to the heart, even in advanced stages. This case illustrates several points, including the presentation of a cardiac metastasis mimicking ischemic cardiac disease on electrocardiogram. The diagnosi...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199302000-00019
更新日期:1993-02-01 00:00:00
abstract::"Sick building syndrome" (SBS) is one of the more colorful terms describing an increasingly common pattern of symptoms found among workers in modern office buildings. Core symptoms include lethargy, mucous membrane irritation, headache, eye irritation, and dry skin. To prompt a diagnosis of SBS, these otherwise common...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199101000-00015
更新日期:1991-01-01 00:00:00
abstract::A new era in the treatment of immune-mediated inflammatory disorders has begun with the clinical availability of anticytokine therapy. Biological agents that are currently available include 3 agents that decrease the activity of tumor necrosis factor-alpha (infliximab, adalimumab, etanercept) and an interleukin-1 rece...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/01.SMJ.0000153119.37032.8B
更新日期:2005-02-01 00:00:00
abstract::The aim of this project was to review the course of infants referred for consideration of extracorporeal membrane oxygenation (ECMO) to identify maximal ventilator settings that, when exceeded, did not provide clinical benefit to the patient. These settings might then be used in defining failure of conventional mechan...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199706000-00009
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND:Many hospitalized anemic patients do not undergo appropriate evaluation. We hypothesized that specific clinical variables were likely to be important in triggering evaluation for iron deficiency anemia. METHODS:We prospectively identified 637 consecutive anemic patients without acute gastrointestinal bleedi...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181520392
更新日期:2007-10-01 00:00:00
abstract::We have described three patients with diabetes and renal insufficiency who had hyperkalemia during heparin therapy. These cases lend support to previous findings, and emphasize the clinical importance of this entity. We believe that heparin-induced hyperkalemia is a potentially life-threatening problem that is more co...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-198711000-00029
更新日期:1987-11-01 00:00:00
abstract::A woman developed anterior uveitis at age 24, inflammatory bowel disease at age 29, and ankylosing spondylitis at age 45 by history. There were frequent recurrences. An HLA-B27 test was positive at age 53. The literature indicates that all of these conditions together in a HLA-B27-positive woman are uncommon. Physicia...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/01.smj.0000215747.80424.2d
更新日期:2006-05-01 00:00:00
abstract::I report my experience during one 6-month period as the sole rheumatologist running a weekly clinic at a small community hospital. The report illustrates the impact of rheumatologic expertise in an environment well-served by generalists and other medical subspecialists. This experience identifies important gaps in the...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199503000-00004
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND:Although dizziness is a common symptom in both primary care and referral practices, the relative frequency of various causes has not been well delineated. METHODS:A MEDLINE search identified 12 articles containing original data on the etiology of dizziness in consecutive patients. Study sites included prima...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:
更新日期:2000-02-01 00:00:00
abstract::Extreme bilateral protrusio acetabuli is an unusual complication of hematologic disease. We have described a patient with sickle cell anemia who had this complication probably as a result of osteopenia. Thus sickle cell anemia should be added to the list of potential causes of protrusio acetabuli. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199003000-00018
更新日期:1990-03-01 00:00:00
abstract::The charts of 663 patients who had cholecystectomy were reviewed to determine the usefulness of preoperative radiologic examination of the upper gastrointestinal tract. In 14% of the patients a positive finding was reported. However, slightly less than half of these findings were confirmed at surgery. Only 2.9% of the...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197705000-00014
更新日期:1977-05-01 00:00:00
abstract::Atomoxetine (Strattera®, Eli Lilly and Co.) is the first non-stimulant drug in the United States (US) to be approved for the treatment of attention deficit hyperactivity disorder (ADHD). In the past, physicians have been concerned about the safety of a variety of ADHD medications. As a result, non-stimulant drugs were...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e318205e575
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:To provide a succinct and updated discussion on common ear, nose, and throat (ENT) disorders encountered by primary care physicians. METHODS:Review of recent and pertinent literature. RESULTS:Recent data was identified via a PubMed search as well as commonly utilized texts in otolaryngology. DISCUSSION:Whi...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/01.smj.0000233214.49561.c1
更新日期:2006-10-01 00:00:00
abstract::We report the case of a 29-year-old woman who had acute cytomegalovirus hepatitis superimposed on previously unrecognized chronic hepatitis B infection. We then review the diagnostic approach to acute hepatitis and positive hepatitis B surface antigen. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199612000-00017
更新日期:1996-12-01 00:00:00
abstract::Dysphagia is a commonly encountered patient complaint. The differential diagnosis for dysphagia is extensive. One long-recognized etiology of dysphagia is cervical osteophytosis. Degenerative joint disease, ankylosing spondylosis, and diffuse idiopathic skeletal hyperostosis (DISH) can all cause cervical osteophyte fo...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199708000-00020
更新日期:1997-08-01 00:00:00
abstract::Between 1972 and 1985, 39 patients with superior vena cava syndrome were admitted to the Medical College of Georgia Hospitals. I have reviewed the hospital courses of these patients and compared clinical and laboratory findings with those reported in previous series. The syndrome was malignant in 34 patients (mean age...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198710000-00011
更新日期:1987-10-01 00:00:00
abstract::A 37-year-old black man with presumed Pneumocystis carinii pneumonia who was treated with systemic IV pentamidine had fatal pancreatitis and massive hepatomegaly. Fatal pancreatitis can occur with no hemorrhagic changes seen at autopsy. Awareness of the relationship between pentamidine and pancreatitis should be empha...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1991-06-01 00:00:00
abstract::A case of Wuchereria bancrofti filariasis was recently seen in a Haitian immigrant in Charleston, SC. The Caribbean area is a known endemic focus for this organism. With the increased numbers of immigrants from that area, it is likely that other such cases will be seen in the US. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198504000-00032
更新日期:1985-04-01 00:00:00
abstract::Ours is apparently the first reported pediatric case of Stomatococcus mucilaginosus bacteremia. It is the second reported case of S mucilaginosus catheter-associated infection, but the first case successfully treated without removing the central venous catheter. This unusual organism should be added to the list of opp...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199103000-00029
更新日期:1991-03-01 00:00:00
abstract::Extraskeletal dedifferentiated chondrosarcomas (DC) are uncommon tumors that predominantly occur in the head and neck. Herein, we describe a case of pulmonary DC detected in a patient with systemic sclerosis and presenting with a symptomatic large pleural effusion and a pulmonary lobar consolidation on chest imaging. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181ad6236
更新日期:2009-08-01 00:00:00
abstract::Nearly three million persons in the United States are viremic with hepatitis C (HCV). Despite a decreasing incidence of HCV in this country, the prevalence of HCV-related chronic liver disease is increasing. Most infections in the United States are acquired by intravenous drug use. The chronicity rate of HCV is high, ...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/01.SMJ.0000118903.35704.30
更新日期:2004-04-01 00:00:00
abstract::Despite the remarkably low mortality from poisonous snakebites in the United States during the past few years, there has been little improvement in preventing deformities of digits. Using a retrospective study of 207 cases of poisonous snakebite, I present a method that has been highly successful in avoiding deformiti...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198506000-00020
更新日期:1985-06-01 00:00:00
abstract:OBJECTIVES:Shear wave elastography (SWE) is an emerging technology that assesses hepatic fibrosis. The aim of our study was to determine the diagnostic accuracy of General Electric (GE) Healthcare's LOGIQ E9 SWE in patients with chronic hepatitis C virus using liver biopsy as the reference standard. METHODS:The liver ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000562
更新日期:2016-11-01 00:00:00
abstract::An example of a blind-ending branch of a bifid ureter in a woman presenting with a urinary tract infection is reported. Definition, diagnosis, and treatment of this anomaly are discussed. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197907000-00031
更新日期:1979-07-01 00:00:00