Role of biological agents in immune-mediated inflammatory diseases.

Abstract:

:A new era in the treatment of immune-mediated inflammatory disorders has begun with the clinical availability of anticytokine therapy. Biological agents that are currently available include 3 agents that decrease the activity of tumor necrosis factor-alpha (infliximab, adalimumab, etanercept) and an interleukin-1 receptor antagonist (anakinra), with many more in development. Those extraordinarily effective medications are an important addition to our therapeutic armamentarium, and, although originally developed for rheumatoid arthritis and Crohn disease, have been found to be efficacious in the treatment of seronegative spondyloarthropathies (psoriatic arthritis, ankylosing spondylitis) and juvenile rheumatoid arthritis. Their role is currently being defined in other autoimmune disorders such as uveitis, sarcoidosis, interstitial lung disease, vasculitis, inflammatory myopathies, graft-versus-host disease, and Sjögren syndrome.

journal_name

South Med J

journal_title

Southern medical journal

authors

Efthimiou P,Markenson JA

doi

10.1097/01.SMJ.0000153119.37032.8B

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

192-204

issue

2

eissn

0038-4348

issn

1541-8243

journal_volume

98

pub_type

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