Abstract:
:Nearly three million persons in the United States are viremic with hepatitis C (HCV). Despite a decreasing incidence of HCV in this country, the prevalence of HCV-related chronic liver disease is increasing. Most infections in the United States are acquired by intravenous drug use. The chronicity rate of HCV is high, reaching 85% in some populations, and the risk of progression to advanced liver disease is as high as 20% within twenty years of infection. Host factors like alcohol use accelerate the rate of progression. The enzyme immunoassay is the preferred initial test for diagnosis; the third generation assay has greater than a 99% specificity in immunocompetent patients. Barring contraindications, the standard of care for treatment of chronic HCV has become pegylated interferon and ribavirin. With this therapy, the cure rate for treatment-naïve patients is about 55%, but rates are higher in certain groups. Common side effects of therapy include neuropsychiatric symptoms, influenza-like symptoms and hematological abnormalities.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Pearlman BLdoi
10.1097/01.SMJ.0000118903.35704.30subject
Has Abstractpub_date
2004-04-01 00:00:00pages
364-73; quiz 374issue
4eissn
0038-4348issn
1541-8243journal_volume
97pub_type
杂志文章,评审abstract:BACKGROUND:The aim of this study was to determine the prevalence of impairments relevant to upper extremity following breast cancer surgery and its impact on disability and health-related quality of life. METHODS:Sixty-seven female patients being treated with modified radical mastectomy or breast conserving surgery we...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181c38c41
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVES:To determine the documentation frequency of informed consent for women undergoing a trial of nonemergent instrumental delivery. STUDY DESIGN:A retrospective chart review of instrumented vaginal deliveries from 1992 to 2005 was performed. Cases were identified from a Labor and Delivery database and hospital ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.smj.0000243076.86803.09
更新日期:2006-12-01 00:00:00
abstract::This paper reviews 218 patients who had outpatient meniscectomy at the University of Virginia between January 1974 and June 1977. Only one patient (0.46%) returned before his scheduled visit. Three patients (1.4%) had superficial wound infections. One (0.46%) had a pulmonary embolus several weeks postoperatively. Twel...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198007000-00018
更新日期:1980-07-01 00:00:00
abstract::A 46-year-old woman had features of acute pulmonary edema soon after taking hydrochlorothiazide (HCTZ) for the first time. Although 31 cases of HCTZ-induced pulmonary edema have been reported in the world literature since it was first described in 1968, little is known about this clinical entity. Because its presence ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199911000-00013
更新日期:1999-11-01 00:00:00
abstract::Phenytoin has traditionally been used for both prophylaxis and acute treatment of alcohol withdrawal seizures. With the exception of a well defined subgroup of withdrawing patients, this may not be appropriate. Chronic anticonvulsant therapy is not indicated without evidence of another underlying seizure diathesis. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197809000-00015
更新日期:1978-09-01 00:00:00
abstract:BACKGROUND:Many hospitalized anemic patients do not undergo appropriate evaluation. We hypothesized that specific clinical variables were likely to be important in triggering evaluation for iron deficiency anemia. METHODS:We prospectively identified 637 consecutive anemic patients without acute gastrointestinal bleedi...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181520392
更新日期:2007-10-01 00:00:00
abstract::We have reported two cases involving bacteremic patients who failed to respond adequately to the investigational agent daptomycin. Despite apparent sensitivity of the organisms, therapy was unsuccessful in both patients using the recommended dosage. The sponsor of daptomycin is currently reevaluating the recommendatio...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198911000-00018
更新日期:1989-11-01 00:00:00
abstract::The diagnoses of complete obstruction in a duplicated renal collecting system and ureterocele can be made with a high degree of confidence by ultrasound. Two children presenting with abdominal masses were examined by gray scale ultrasonography which demonstrated large cystic masses dorsal to and displacing the lower p...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198008000-00018
更新日期:1980-08-01 00:00:00
abstract::With the advent of ultrasonography, perinephric fluid collection can be easily diagnosed and confirmed by fine needle aspiration. In the past these cases sometimes went undiagnosed for several months. We did fine needle aspiration under the guidance of ultrasonography in 16 patients without complications. The aspirant...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198506000-00018
更新日期:1985-06-01 00:00:00
abstract::A case of nephrotic syndrome due to minimal change renal disease was associated with minimally symptomatic nodular sclerosing Hodgkin's disease in a 15-year-old girl. Although minimal renal disease is the most frequently described biopsy finding in this paraneoplastic syndrome, the combination of nodular sclerosing Ho...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198205000-00027
更新日期:1982-05-01 00:00:00
abstract::A review of 228 cholecystectomies done over a two-year period revealed 15 cases (6.6%) in which gallstones were absent. These 15 patients were all characterized by colicky abdominal pain in the right upper quadrant, with a mean duration of eight months. Ultrasonographic examination was falsely positive for gallstones ...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-198811000-00005
更新日期:1988-11-01 00:00:00
abstract::I reviewed 100 consecutive radiologic examinations with particular attention to the clinical information included. The referring physician originated this clinical information in only 33% of cases. Other personnel, including nurses and aides, added information on the requisitions 57% of the time. When nonphysician per...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1983-02-01 00:00:00
abstract::We have described the radiographic features of a case of solitary giant hepatocellular carcinoma in a noncirrhotic liver. It was angiographically avascular and resembled a massive metastatic tumor. Most hepatocellular carcinomas appear highly vascular on angiography. Hypovascularity may sometimes be encountered in the...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198310000-00027
更新日期:1983-10-01 00:00:00
abstract::Single-agent chemotherapy (actinomycin D) was administered in cyclic regimens to 26 patients with metastatic, nonseminomatous testicular carcinoma. Twenty-five patients were evaluable, 9 with stage II disease and 16 with stage III disease. A 37.5% response rate in stage III disease is reported and all patients are lon...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197608000-00017
更新日期:1976-08-01 00:00:00
abstract:OBJECTIVES:Accurate and consistent documentation of pain management, including patient responses regarding improvement in pain scores, is essential for improving patient care. The objective of the project was to evaluate the current prescribing patterns and to review the current documentation for opioid-managed, chroni...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3182296f20
更新日期:2011-09-01 00:00:00
abstract::The patient we have described had lower extremity numbness, paresthesias, constipation, urinary retention, and sexual dysfunction. Laboratory evaluation confirmed a diagnosis of acute intermittent porphyria (AIP). Vitamin B6 and glucose therapy initiated resolution of symptoms. The sensory neuropathy described here is...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1991-05-01 00:00:00
abstract::A patient presented with scrotal cellulitis as a complication of infusing 900 ml saline into his scrotum. He had obtained a kit along with explicit instructions for performing the infusion through the Internet. This practice may be more widespread than expected. An Internet search revealed many references to this proc...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000078368.00806.A7
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:Surveys in recent years show that office emergencies are likely to occur in pediatric offices and that most offices are not equipped to deal with these situations. METHODS:To determine the pediatrician's preparedness to manage emergencies, we surveyed a randomly selected sample of 240 office-based pediatric...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199808000-00008
更新日期:1998-08-01 00:00:00
abstract::For over a decade there has been concern about hepatitis related to halothane anesthesia. No dose relationship or other direct cause has ever been established, and jaundice has been found to occur after other anesthetics for surgical operations. Enflurane is a newer halogenated compound with a remarkable record of saf...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197807000-00012
更新日期:1978-07-01 00:00:00
abstract::Implantation of automatic internal cardiac defibrillators (AICD) for management of arrhythmias necessitates the induction of ventricular fibrillation (VF) to test the device adequately. The profound hypotension associated with induced arrhythmia and subsequent circulatory arrest may result in cerebral ischemia. To cha...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199305000-00009
更新日期:1993-05-01 00:00:00
abstract::We reviewed the maternal transfers for one year (1980) to the Emory Perinatal Center, a tertiary care center for North Georgia. Of 445 telephone consultations or patient referrals, 150 women gave birth at the tertiary center. Indications for maternal transfer were predominantly based on the needs or anticipated needs ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198307000-00004
更新日期:1983-07-01 00:00:00
abstract:OBJECTIVES:Immunochromatographic urine pneumococcal antigen testing (ICT) has become a common diagnostic tool for those presenting with possible invasive pneumococcal disease. The incidence and clinical impact of ICT false-positivity on hospitalized patients has not been assessed outside of specific patient subpopulati...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3182273b82
更新日期:2011-08-01 00:00:00
abstract::Angioedema has not been associated with losartan therapy in hemodialysis patients, as it has been with angiotensin converting enzyme (ACE) inhibitors. We report the case of a hemodialysis patient who previously had angioedema after therapy with ACE inhibitors and again had angioedema while taking losartan. We suggest ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199705000-00020
更新日期:1997-05-01 00:00:00
abstract::With the advent and increased use of chemotherapeutic agents and radiation therapy, cancer survival rates have increased. With increased survival, both acute and chronic cardiotoxic adverse effects have emerged. The growing need for managing the treatment of individuals with chemotherapy-induced cardiotoxicity has led...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.14423/SMJ.0000000000000232
更新日期:2015-02-01 00:00:00
abstract::Treatment of major abdominal vascular injuries is a challenge. Since 1973, 93 patients have been treated at our institution for 147 abdominal vascular injuries. The majority of these injuries (67%) resulted from penetrating trauma in young men between 21 and 30 years of age. Upon admission 72% of the patients were in ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198510000-00003
更新日期:1985-10-01 00:00:00
abstract:OBJECTIVES:The objective of this population-based study was to examine the relationship between race, socioeconomic characteristics (socioeconomic status, SES), physician density, and colon cancer incidence in Alabama. METHODS:Data for 5,788 colon cancer cases from 1996 to 1999 provided by the Alabama Statewide Cancer...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.smj.0000184844.01148.10
更新日期:2005-11-01 00:00:00
abstract::Disseminated histoplasmosis is an unusual complication in endemic areas and has been reported in patients with an immunodeficient state, either from human immunodeficiency virus (HIV) infection or transplantation. In the non-HIV population, rare cases of disseminated histoplasmosis have been reported in patients with ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199812000-00012
更新日期:1998-12-01 00:00:00
abstract::We present this case to emphasize the potentially fatal outcome of supraventricular tachycardia in infancy, particularly if it has been undiagnosed for several days. Certainly, careful monitoring needs to take place during any attempt at cardioversion or any other noxious stimulation of the patient. Bicarbonate therap...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199401000-00023
更新日期:1994-01-01 00:00:00
abstract::Diabetes during pregnancy is associated with insulin resistance, an increase in insulin requirement, and a greater tendency to ketosis and ketoacidosis. Increased perinatal mortality is related to maternal hyperglycemia and can be decreased dramatically with strict control of plasma glucose during pregnancy and a smoo...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197801000-00012
更新日期:1978-01-01 00:00:00
abstract::Ninety-four children with typhoid fever presented with the primary complaints of fever, diarrhea, and vomiting. Fifty-two percent had hepatomegaly and derangements of SGOT and LDH. None developed hepatic decompensation and all had rapid clinical recovery. The abnormal liver function test served no prognostic purpose. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197607000-00037
更新日期:1976-07-01 00:00:00